Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Kevin D, Bunting"'
Autor:
Jonathan Metts, Heath L. Bradley, Zhengqi Wang, Neil P. Shah, Reuben Kapur, Jack L. Arbiser, Kevin D. Bunting
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid leukemia (AML). Inhibitors to FLT3 have already been tested in clinical trials, howev
Externí odkaz:
https://doaj.org/article/194b5d0b84eb4fd8aa2867b88dfc9dc5
Autor:
Zhengqi Wang, Tamisha Y. Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T. Bunting, Pamela A. Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Demin Wang, Renren Wen, Kevin D. Bunting
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Inflammatory Bowel Disease (IBD) is a multi-factorial chronic inflammation of the gastrointestinal tract prognostically linked to CD8+ T-cells, but little is known about their mechanism of activation during initiation of colitis. Here, Grb2-associate
Externí odkaz:
https://doaj.org/article/2a6344e317274854947962fedcc832e3
Autor:
Zhengqi Wang, Tian Mi, Heath L. Bradley, Jonathan Metts, Himalee Sabnis, Wandi Zhu, Jack Arbiser, Kevin D. Bunting
Publikováno v:
Antioxidants, Vol 10, Iss 6, p 956 (2021)
Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathway
Externí odkaz:
https://doaj.org/article/55cef3b857214f6c9597debf32e669f4
Autor:
Peter A. Cohen, James H. Finke, Brian Rini, Kevin D. Bunting, Geqiang Li, Shadi Swaidani, Joanna Ireland, Patricia Rayman, Jennifer S. Ko
Supplementary Table 1 from Direct and Differential Suppression of Myeloid-Derived Suppressor Cell Subsets by Sunitinib Is Compartmentally Constrained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315668c7dd2d95a9b25a3f3a2638c7c7
https://doi.org/10.1158/0008-5472.22386428
https://doi.org/10.1158/0008-5472.22386428
Stromal STAT5-mediated trophic activity regulates hematopoietic multipotent progenitor niche factors
Autor:
Zhengqi Wang, Grace Emmel, Hong Seo Lim, Wandi Zhu, Astrid Kosters, Eliver E.B. Ghosn, Peng Qiu, Kevin D. Bunting
Signal transducer and activator of transcription 5 (STAT5a and STAT5b) are intrinsically critical for normal hematopoiesis but are also expressed in stromal cells. Here, STAT5ab knockout (KO) was generated with a variety of bone marrow hematopoietic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5559f33b9237abcfb456687caaa37b1
https://doi.org/10.1101/2022.10.07.511255
https://doi.org/10.1101/2022.10.07.511255
Autor:
Anindya Chatterjee, Joydeep Ghosh, Baskar Ramdas, Raghuveer Singh Mali, Holly Martin, Michihiro Kobayashi, Sasidhar Vemula, Victor H. Canela, Emily R. Waskow, Valeria Visconte, Ramon V. Tiu, Catherine C. Smith, Neil Shah, Kevin D. Bunting, H. Scott Boswell, Yan Liu, Rebecca J. Chan, Reuben Kapur
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1333-1348 (2014)
Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been impl
Externí odkaz:
https://doaj.org/article/3fb0e4f417624b859de3a4859396cf8a
Autor:
Kevin D. Bunting, Mignon L. Loh, Yuhan Yan, Qianjin Li, Chao Chen, Elliot Stieglitz, Cheng-Kui Qu, Lei Dong
Publikováno v:
Blood advances, vol 6, iss 1
Blood Advances
Blood Advances
Key Points Normal hematopoiesis is suppressed by JMML tumor cells as a result of the aberrant activation and exhaustion of stem cells.JMML cells impose inflammatory stress on normal stem cells by over production of IL-1β.
Development of normal
Development of normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77991d955cc072376e02805ecd355293
https://escholarship.org/uc/item/4n68p98t
https://escholarship.org/uc/item/4n68p98t
Autor:
Kevin D. Bunting, Robert G. Hawley
Publikováno v:
The Scientific World Journal, Vol 2, Pp 983-995 (2002)
Hematopoietic stem cells (HSCs) are the best studied of the tissue-specific stem cells. By definition, HSCs have long been regarded as restricted to formation of blood cells of both the lymphoid and myeloid lineages. HSCs residing in the bone marrow
Externí odkaz:
https://doaj.org/article/6b8753d5f19545da99a5eddb5f9c9054
Autor:
Himalee S. Sabnis, Tian Mi, Wandi Zhu, Heath L. Bradley, Jonathan L. Metts, Zhengqi Wang, Kevin D. Bunting, Jack L. Arbiser
Publikováno v:
Antioxidants
Volume 10
Issue 6
Antioxidants, Vol 10, Iss 956, p 956 (2021)
Volume 10
Issue 6
Antioxidants, Vol 10, Iss 956, p 956 (2021)
Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d028237db65cee9a2fe226522018d3
https://pubmed.ncbi.nlm.nih.gov/34203664
https://pubmed.ncbi.nlm.nih.gov/34203664
Publikováno v:
Advances in Hematology, Vol 2012 (2012)
Significant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia (JMML) have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targe
Externí odkaz:
https://doaj.org/article/a3c807d4cc7147a0ab0d4962d471ff00