Zobrazeno 1 - 10
of 1 264
pro vyhledávání: '"Kevin CHEN"'
Autor:
Nicole C. Shaw, Kevin Chen, Kathryn O. Farley, Mitchell Hedges, Catherine Forbes, Gareth Baynam, Timo Lassmann, Vanessa S. Fear
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background SETBP1 Haploinsufficiency Disorder (SETBP1-HD) is characterised by mild to moderate intellectual disability, speech and language impairment, mild motor developmental delay, behavioural issues, hypotonia, mild facial dysmorphisms,
Externí odkaz:
https://doaj.org/article/12a81379ba3148f99409d98a514ee63e
Autor:
Hidenori Kitai, Philip H. Choi, Yu C. Yang, Jacob A. Boyer, Adele Whaley, Priya Pancholi, Claire Thant, Jason Reiter, Kevin Chen, Vladimir Markov, Hirokazu Taniguchi, Rui Yamaguchi, Hiromichi Ebi, James Evans, Jingjing Jiang, Bianca Lee, David Wildes, Elisa de Stanchina, Jacqueline A. M. Smith, Mallika Singh, Neal Rosen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Current KRASG12C (OFF) inhibitors that target inactive GDP-bound KRASG12C cause responses in less than half of patients and these responses are not durable. A class of RASG12C (ON) inhibitors that targets active GTP-bound KRASG12C blocks ERK
Externí odkaz:
https://doaj.org/article/7ad6de68f66945a2a3cb9c50ceaaf9b5
Autor:
James Chettle, Raymond J. Louie, Olivia Larner, Robert Best, Kevin Chen, Josephine Morris, Zinaida Dedeic, Anna Childers, R. Curtis Rogers, Barbara R. DuPont, Cindy Skinner, Sébastien Küry, Kevin Uguen, Marc Planes, Danielle Monteil, Megan Li, Aviva Eliyahu, Lior Greenbaum, Nofar Mor, Thomas Besnard, Bertrand Isidor, Benjamin Cogné, Alyssa Blesson, Anne Comi, Ingrid M. Wentzensen, Blake Vuocolo, Seema R. Lalani, Roberta Sierra, Lori Berry, Kent Carter, Stephan J. Sanders, Sarah P. Blagden
Publikováno v:
HGG Advances, Vol 5, Iss 4, Pp 100345- (2024)
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects approximately 4% of males and 1% of females in the United States. While causes of ASD are multi-factorial, single rare genetic variants contribute to around 2
Externí odkaz:
https://doaj.org/article/e0e49cd5da4340678f3756e671807267
Autor:
Shetal A. Patel, MD, PhD, Young Whang, MD, PhD, Chaely Medley, NP, Kevin Chen, PharmD, Jasmine Jordan, BS, Dante Bortone, PhD, Benjamin Vincent, MD, PhD, Jared Weiss, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 10, Pp 100712- (2024)
A 20-year-old man with metastatic large cell neuroendocrine carcinoma of the lung was treated with the delta-like ligand 3–targeting bispecific T cell engager, tarlatamab. Treatment was complicated by transient cytokine release syndrome but resulte
Externí odkaz:
https://doaj.org/article/8000f77d3fd64147a7f544962cd9ad9f
Autor:
John S. Babich, BS, Michelle McMacken, MD, Lilian Correa, MA, MPH, RDN, Krisann Polito-Moller, BS, NBC-HWC, Kevin Chen, MD, MHS, Eric Adams, MPA, Samantha Morgenstern, MS, RD, CDN, Mitchell Katz, MD, Theodore G. Long, MD, MHS, Shivam Joshi, MD, Andrew B. Wallach, MD, Sapana Shah, MD, MPH, Rebecca Boas, MD, MBA
Publikováno v:
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 8, Iss 3, Pp 279-292 (2024)
Chronic diseases are the leading cause of death and disability in the United States, and much of this burden can be attributed to lifestyle and behavioral risk factors. Lifestyle medicine is an approach to preventing and treating lifestyle-related ch
Externí odkaz:
https://doaj.org/article/3a0d29625dfd4165b0e7a2629d8123f7
Autor:
Melanie Powis, Rinku Sutradhar, Simron Singh, Shabbir Alibhai, Saidah Hack, Abed Baiad, Kevin Chen, Huaqi Li, Zuhal Mohmand, Monika K. Krzyzanowska
Publikováno v:
Current Oncology, Vol 31, Iss 4, Pp 2328-2340 (2024)
We undertook a retrospective study to compare the quality of care delivered to a cohort of newly diagnosed adults with colon, rectal or anal cancer during the early phase of COVID-19 (02/20–12/20) relative to the same period in the year prior (the
Externí odkaz:
https://doaj.org/article/0a18e5c7cc3d49379a4d84c1caafa39d
Autor:
Erick F. Saldanha, Melanie Powis, Divya Sharma, Osvaldo Espin-Garcia, Saidah Hack, Felicia Cavalher, Maria Rita Costa, Maria Simoes, Huaqi Li, Abed Baiad, Kevin Chen, Zuhul Mohmand, Peter Nakhla, Samuel Aguiar, Rachel Riechelmann, Monika K. Krzyzanowska
Publikováno v:
JCO Global Oncology, Iss 10 (2024)
PURPOSEThe early phase of the COVID-19 pandemic affected cancer care globally. Evaluating the impact of the pandemic on the quality of cancer care delivery is crucial for understanding how changes in care delivery may influence outcomes. Our study co
Externí odkaz:
https://doaj.org/article/14f5593204b1432f9bb5befab66d01d7
Autor:
Omar Hamam, Julie Gudenkauf, Rawan Moustafa, Andrew Cho, Daniel Montes, Muhannad Sharara, Abdallah Moustafa, Mahla Radmard, Mehreen Nabi, Kevin Chen, Sadra Sepehri, Christopher Shin, Ishan Mazumdar, Minsoo Kim, Alireza Mohseni, Ajay Malhotra, Javier Romero, Vivek Yedavalli
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 16 (2024)
Background Collateral status (CS) plays a crucial role in infarct growth rate, risk of postthrombectomy hemorrhage, and overall clinical outcomes in patients with acute ischemic stroke (AIS) secondary to anterior circulation large‐vessel occlusions
Externí odkaz:
https://doaj.org/article/f17a4714d0504af0a857fcc86ccbd923
Autor:
Peter K. Firouzbakht, MD, Andi Zhang, BA, David C. Nguyen, MD, Cedar Slovacek, MD, Anna E. Daytz, BS, Neil Tanna, MD, MBA, Kevin Chen, MD
Publikováno v:
Plastic and Reconstructive Surgery, Global Open, Vol 12, Iss 6, p e5888 (2024)
Background:. Scrubs have become widespread office attire for plastic surgeons. The purpose of this study is to evaluate the public perception of scrub color and style for plastic surgeons. Methods:. A crowdsourced survey was performed via MTurk. Resp
Externí odkaz:
https://doaj.org/article/119919a8ffe5485f9ca49a64d150718c
Autor:
Jianzhou Liu, Jing Huang, Jun Lu, Runze Ouyang, Wenchao Xu, Jianlu Zhang, Kevin Chen-Xiao, Chengjun Wu, Dong Shang, Vay Liang W(Bill) Go, Junchao Guo, Gary Guishan Xiao
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110027- (2024)
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a poor prognosis due to inefficient diagnosis and tenacious drug resistance. Obg-like ATPase 1 (OLA1) is overexpressed in many malignant tumors. The molecular mechani
Externí odkaz:
https://doaj.org/article/c65a271b28334e5ea491affa5f446db5