Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kevin C. Ray"'
Autor:
Vincent Quoc-Huy Trinh, Ting-Fang Lee, Sara Lemoinne, Kevin C. Ray, Maria D. Ybanez, Takuma Tsuchida, James K. Carter, Judith Agudo, Brian D. Brown, Kemal M. Akat, Scott L. Friedman, Youngmin A. Lee
Organ homeostasis is maintained by regulated proliferation of distinct cell populations. In mouse liver, cyclin D1-positive hepatocytes in the midlobular zone repopulate the parenchyma at a constant rate to preserve liver homeostasis. The mitogenic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8637eeac0ec1514a20feba18a720fe50
https://doi.org/10.1101/2023.03.03.531042
https://doi.org/10.1101/2023.03.03.531042
Autor:
Qin Zhang, Dennis K. Jeppesen, James N. Higginbotham, Ramona Graves-Deal, Vincent Q. Trinh, Marisol A. Ramirez, Yoojin Sohn, Abigail C. Neininger, Nilay Taneja, Eliot T. McKinley, Hiroaki Niitsu, Zheng Cao, Rachel Evans, Sarah E. Glass, Kevin C. Ray, William H. Fissell, Salisha Hill, Kristie Lindsey Rose, Won Jae Huh, Mary Kay Washington, Gregory Daniel Ayers, Dylan T. Burnette, Shivani Sharma, Leonard H. Rome, Jeffrey L. Franklin, Youngmin A. Lee, Qi Liu, Robert J. Coffey
Publikováno v:
Nature Cell Biology
Extracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular nanoparticle, termed supermere. Supermeres are morphologically distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7f73ed53b484e4d6259c39e78954d2
https://doi.org/10.1038/s41556-021-00805-8
https://doi.org/10.1038/s41556-021-00805-8
Publikováno v:
Am J Pathol
A unique and complex microstructure underlies the diverse functions of the liver. Breakdown of this organization, as occurs in fibrosis and cirrhosis, impairs liver function and leads to disease. The role of integrin β1 was examined both in establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a9a1090860159dd40b73e26a9b15da
https://doi.org/10.1016/j.ajpath.2020.10.011
https://doi.org/10.1016/j.ajpath.2020.10.011
Autor:
Kevin C Ray, Kayla M Bell, Jingbo Yan, Guoqiang Gu, Christine H Chung, M Kay Washington, Anna L Means
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16786 (2011)
Activating mutations in the Kras gene are commonly found in some but not all epithelial cancers. In order to understand the susceptibility of different epithelial tissues to Kras-induced tumorigenesis, we introduced one of the most common Kras mutati
Externí odkaz:
https://doaj.org/article/553676a688e5490abdd37c7becac956a
Autor:
Charles C. Hong, Martin J. Dib, Ryota Masuzaki, Audrey Y. Frist, Yuki Oya, Kaori Kuramitsu, Darren W. Engers, Kevin C. Ray, Kenneth D. Bloch, Corey R. Hopkins, Karen J. Ho, Nhue Do, Craig W. Lindsley, Paul B. Yu, Seth J. Karp, Daisuke Tsugawa
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:549-558
Pharmacologic agents to enhance liver regeneration after injury would have wide therapeutic application. Based on previous work suggesting inhibition of bone morphogenetic protein (BMP) signaling stimulates liver regeneration, we tested known and nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4a55a2581d9aaf10074d03a8c13367
https://doi.org/10.1124/jpet.114.216903
https://doi.org/10.1124/jpet.114.216903
Autor:
Jeffrey L. Franklin, Howard C. Crawford, Kevin C. Ray, Connie J. Weaver, Stacy A. Blaine, Anna L. Means, K E Guess, Yan Song, M E Moss, Frank Revetta, L R Bridges, Robert J. Coffey, James N. Higginbotham, Mary Kay Washington
Publikováno v:
Oncogene
Pancreatic cancer remains as one of the most deadly cancers with few treatment options at late stages and little information about how it develops through earlier stages. Activating mutation of the Kras gene has been implicated in, but is not suffici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f555c446519dfa66634dc533683e5e6
http://europepmc.org/articles/PMC3929321
http://europepmc.org/articles/PMC3929321
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 312(5)
Dicer processes microRNAs (miRs) into active forms in a wide variety of tissues, including the liver. To determine the role of Dicer in liver regeneration, we performed a series of in vivo and in vitro studies in a murine 2/3 hepatectomy model. Dicer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa6c7a7bee3c11feb516322c3eb1403
https://pubmed.ncbi.nlm.nih.gov/28232457
https://pubmed.ncbi.nlm.nih.gov/28232457
Autor:
Ryota Masuzaki, Sophia Zhao, Kevin C. Ray, Yuki Oya, M. Todd Valerius, Seth J. Karp, Daisuke Tsugawa
After significant injury, the liver must maintain homeostasis during the regenerative process. We hypothesized the existence of mechanisms to limit hepatocyte proliferation after injury to maintain metabolic and synthetic function. A screen for candi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93df27b589266d1ec10830d988e58ac1
https://europepmc.org/articles/PMC4751379/
https://europepmc.org/articles/PMC4751379/
Autor:
Reginald Anunobi, Mary Kay Washington, Maureen Gannon, Anna L. Means, Kevin C. Ray, Stacy A. Blaine
Publikováno v:
Development. 137:2289-2296
Studies in both humans and rodents have found that insulin(+) cells appear within or near ducts of the adult pancreas, particularly following damage or disease, suggesting that these insulin(+) cells arise de novo from ductal epithelium. We have foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edd1826a590012cfb53162316e9e41b
https://doi.org/10.1242/dev.048421
https://doi.org/10.1242/dev.048421
Publikováno v:
genesis. 46:318-323
Cre/LoxP-mediated DNA recombination allows for gene function and cell lineage analyses during embryonic development and tissue regeneration. Here, we describe the derivation of a K19(CreERT) mouse line in which the tamoxifen-activable CreER(T) was kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec6560afa0cfaa842ee665f6f588aec
https://doi.org/10.1002/dvg.20397
https://doi.org/10.1002/dvg.20397