Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kevin C. Kent Lloyd"'
Autor:
Lydia Teboul, James Amos-Landgraf, Fernando J. Benavides, Marie-Christine Birling, Steve D. M. Brown, Elizabeth Bryda, Rosie Bunton-Stasyshyn, Hsian-Jean Chin, Martina Crispo, Fabien Delerue, Michael Dobbie, Craig L. Franklin, Ernst-Martin Fuchtbauer, Xiang Gao, Christelle Golzio, Rebecca Haffner, Yann Hérault, Martin Hrabe de Angelis, Kevin C. Kent Lloyd, Terry R. Magnuson, Lluis Montoliu, Stephen A. Murray, Ki-Hoan Nam, Lauryl M. J. Nutter, Eric Pailhoux, Fernando Pardo Manuel de Villena, Kevin Peterson, Laura Reinholdt, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Cynthia Smith, Toru Takeo, Louise Tinsley, Jean-Luc Vilotte, Søren Warming, Sara Wells, C. Bruce Whitelaw, Atsushi Yoshiki, Asian Mouse Mutagenesis Resource Association, CELPHEDIA infrastructure, INFRAFRONTIER consortium, International Mammalian Genome Society, International Mouse Phenotyping Consortium, International Society for Transgenic Technologies, Mutant Mouse Resource and Research Centers, Phenomics Australia, RRRC- Rat Resource and Research Center, Guillaume Pavlovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guideline
Externí odkaz:
https://doaj.org/article/81e4d92fe0424d7c9017a0c563ae6724
Autor:
Ying Zhang, Dinesh K. Barupal, Sili Fan, Bei Gao, Chao Zhu, Ann M. Flenniken, Colin McKerlie, Lauryl M. J. Nutter, Kevin C. Kent Lloyd, Oliver Fiehn
Publikováno v:
Metabolites, Vol 13, Iss 8, p 947 (2023)
Although metabolic alterations are observed in many monogenic and complex genetic disorders, the impact of most mammalian genes on cellular metabolism remains unknown. Understanding the effect of mouse gene dysfunction on metabolism can inform the fu
Externí odkaz:
https://doaj.org/article/9147c1f49c814d45a4020b711d579a3d
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 1 (2019)
Over the past decade, new methods and procedures have been developed to generate genetically engineered mouse models of human disease. This At a Glance article highlights several recent technical advances in mouse genome manipulation that have transf
Externí odkaz:
https://doaj.org/article/5c764cd747e042c6b184350d3746c52e
Autor:
Angus Yiu-fai Lee, Kevin C. Kent Lloyd
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 637-642 (2014)
CRISPR/Cas9 technology is a highly promising genome editing tool in the mouse, potentially overcoming the costs and time required for more traditional gene targeting methods in embryonic stem (ES) cells. Recently, compared to the wildtype nuclease, p
Externí odkaz:
https://doaj.org/article/cd9354be87eb44c19f4a345fd861e117
Publikováno v:
The Journal of Immunology. 178:S129-S130
Retinoid X receptor (RXR) agonists, including the vitamin A metabolite 9-cis retinoic acid, decrease T lymphocyte apoptosis and promote Th2 development ex vivo. To examine the in vivo role of RXR-alpha in T lymphocytes we disrupted the Rxra gene usin