Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kevin C. Dean"'
Autor:
Fenghua Chen, Xiao Liu, Yao Chen, John Y. Liu, Huayi Lu, Wei Wang, Xiaoqin Lu, Kevin C. Dean, Ling Gao, Henry J. Kaplan, Douglas C. Dean, Xiaoyan Peng, Yongqing Liu
Publikováno v:
EBioMedicine, Vol 52, Iss , Pp - (2020)
Background: The retinal pigment epithelium (RPE) has the potential to regenerate the entire neuroretina upon retinal injury in amphibians. In contrast, this regenerative capacity has been lost in mammals. The reprogramming of differentiated somatic c
Externí odkaz:
https://doaj.org/article/ac23221488c84a19ad6eb7ce6597438e
Autor:
Yongqing Liu, Laura Siles, Xiaoqin Lu, Kevin C. Dean, Miriam Cuatrecasas, Antonio Postigo, Douglas C. Dean
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Transition from premalignant lesion to cancer cell highlights tumor initiation. Here, the authors use a model of K-Ras-initiated lung cancer to document two successive asymmetric divisions, each driven by mitotic polarization of key transcription fac
Externí odkaz:
https://doaj.org/article/df38bfb58c814b399b684abd35f65259
Autor:
Yao Chen, Xiaoqin Lu, Diego E. Montoya-Durango, Yu-Hua Liu, Kevin C. Dean, Douglas S. Darling, Henry J. Kaplan, Douglas C. Dean, Ling Gao, Yongqing Liu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Human uveal melanoma (UM) is a major ocular malignant tumor with high risk of metastasis and requires multiple oncogenic factors for progression. ZEB1 is a zinc finger E-box binding transcription factor known for participating epithelial-mes
Externí odkaz:
https://doaj.org/article/384daa64ce3f4036858f348b898b32c6
Autor:
Patrick A. Scott, Kevin C. Dean, Henry J. Kaplan, Enzo Fortuny, Ashwini Kini, Yao Chen, Yongqing Liu, Eric V. Vukmanic, Robert F. James, Xiaoqin Lu, Wei Wang, Xiao Liu, Tingting Liu, Lei Jin, Yekai Wang, Jianhai Du, Qingxian Lu, Douglas Emery, Douglas C. Dean, San Joon Lee
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1323-1334.e4 (2019)
Cell reports
Cell reports
SUMMARY Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and nighttime vision loss. However, subsequent loss of cone function and high-resolution daylight and color vision is most debilitating. Visual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d65f843d491f9478200fd3684550cd
http://www.sciencedirect.com/science/article/pii/S2211124719308794
http://www.sciencedirect.com/science/article/pii/S2211124719308794
Autor:
Antonio Postigo, Kevin C. Dean, Xiaoqin Lu, Miriam Cuatrecasas, Laura Siles, Yongqing Liu, Douglas C. Dean
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications
A model of K-Ras-initiated lung cancer was used to follow the transition of precancerous adenoma to adenocarcinoma. In hypoxic, Tgf-β1-rich interiors of adenomas, we show that adenoma cells divide asymmetrically to produce cancer-generating cells hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6710d05a596770080dbbe99759afed
http://link.springer.com/article/10.1038/s41467-018-04663-1
http://link.springer.com/article/10.1038/s41467-018-04663-1
Autor:
Yao Chen, Xiaoqin Lu, Ling Gao, Xiaoyan Peng, Yongqing Liu, Kevin C. Dean, Huayi Lu, John Y. Liu, Douglas C. Dean, Xiao Liu, Fenghua Chen, Henry J. Kaplan, Wei Wang
Publikováno v:
EBioMedicine
EBioMedicine, Vol 52, Iss, Pp-(2020)
EBioMedicine, Vol 52, Iss, Pp-(2020)
Background The retinal pigment epithelium (RPE) has the potential to regenerate the entire neuroretina upon retinal injury in amphibians. In contrast, this regenerative capacity has been lost in mammals. The reprogramming of differentiated somatic ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f632514fe61288ff6456249b03090bf0
https://doi.org/10.1016/j.ebiom.2019.102618
https://doi.org/10.1016/j.ebiom.2019.102618
Autor:
Ling Gao, Yongqing Liu, Diego E. Montoya-Durango, Yu-Hua Liu, Douglas C. Dean, Yao Chen, Henry J. Kaplan, Douglas S. Darling, Xiaoqin Lu, Kevin C. Dean
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Human uveal melanoma (UM) is a major ocular malignant tumor with high risk of metastasis and requires multiple oncogenic factors for progression. ZEB1 is a zinc finger E-box binding transcription factor known for participating epithelial-mesenchymal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae307603294014237c0a2c8913274abd
http://europepmc.org/articles/PMC5428321
http://europepmc.org/articles/PMC5428321
Autor:
Ling Gao, Xiao Liu, Ni Xu, Douglas C. Dean, Henry J. Kaplan, Fangtian Dong, Yao Chen, Wei Wang, Xiaoqin Lu, Kevin C. Dean, Yongqing Liu
Publikováno v:
Stem cells (Dayton, Ohio). 35(6)
Müller cells are the major supportive and protective glial cells in the retina with important functions in histogenesis and synaptogenesis during development, and in maintenance of mature neurons as they show to secrete various cytokines and manifes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e45df81509abffa21788cc882a870a3
https://pubmed.ncbi.nlm.nih.gov/28152565
https://pubmed.ncbi.nlm.nih.gov/28152565
Erratum: Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis
Autor:
Yongqing Liu, Xiaoqin Lu, Li Huang, Wei Wang, Guomin Jiang, Kevin C. Dean, Brian Clem, Sucheta Telang, Alfred B. Jenson, Miriam Cuatrecasas, Jason Chesney, Douglas S. Darling, Antonio Postigo, Douglas C. Dean
Publikováno v:
Nature Communications. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b6bf55da289401920842c21692f1a07
https://doi.org/10.1038/ncomms7699
https://doi.org/10.1038/ncomms7699
Autor:
Miriam Cuatrecasas, Alfred B. Jenson, Douglas C. Dean, Jason Chesney, Kevin C. Dean, Douglas S. Darling, Antonio Postigo, Guomin Jiang, Xiaoqin Lu, Wei Wang, Li Huang, Sucheta Telang, Brian F. Clem, Yongqing Liu
Publikováno v:
Nature Communications. 5
Ras pathway mutation is frequent in carcinomas where it induces expression of the transcriptional repressor ZEB1. Although ZEB1 is classically linked to epithelial-mesenchymal transition and tumour metastasis, it has an emerging second role in genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29465e36c3156cec59f99d869112909
https://doi.org/10.1038/ncomms6660
https://doi.org/10.1038/ncomms6660