Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kevin C. Allan"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Mutations in tRNA processing factors can lead to myelin disorders. This study shows that differentiated oligodendrocytes, cells that make the myelin, are characterized by different tRNA modifications and mRNA decay compared to their precursor cells.
Externí odkaz:
https://doaj.org/article/e3f53db27d6b4c708b911c9c925e4f44
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 27, Iss , Pp 101606- (2022)
Purpose: To describe a patient with bilateral peripapillary astrocytic hamartomas with exudation of subretinal fluid into the macula and loss of vision without evidence of choroidal neovascularization. The patient rapidly responded to intravitreal be
Externí odkaz:
https://doaj.org/article/6c6d3a91c2424c5a8af383825b56ca73
Autor:
Angela M. Lager, Olivia G. Corradin, Jared M. Cregg, Matthew S. Elitt, H. Elizabeth Shick, Benjamin L. L. Clayton, Kevin C. Allan, Hannah E. Olsen, Mayur Madhavan, Paul J. Tesar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mo
Externí odkaz:
https://doaj.org/article/71dbdedc40fa404b962276780906a9a8
Autor:
Matthew S. Elitt, H. Elizabeth Shick, Mayur Madhavan, Kevin C. Allan, Benjamin L.L. Clayton, Chen Weng, Tyler E. Miller, Daniel C. Factor, Lilianne Barbar, Baraa S. Nawash, Zachary S. Nevin, Angela M. Lager, Yan Li, Fulai Jin, Drew J. Adams, Paul J. Tesar
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 711-726 (2018)
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancem
Externí odkaz:
https://doaj.org/article/85ceab688bb44f7d8336a4d35cb11973
Autor:
Ajai Tripathi, Christina Volsko, Jessie P. Garcia, Eneritz Agirre, Kevin C. Allan, Paul J. Tesar, Bruce D. Trapp, Goncalo Castelo-Branco, Fraser J. Sim, Ranjan Dutta
Publikováno v:
Cell Reports, Vol 29, Iss 4, Pp 904-919.e9 (2019)
Summary: Remyelination requires the generation of new oligodendrocytes (OLs), which are derived from oligodendrocyte progenitor cells (OPCs). Maturation of OPCs into OLs is a multi-step process. Here, we describe a microRNA expressed by OLs, miR-27a,
Externí odkaz:
https://doaj.org/article/97335eff7e1749298f244aa49f96c578
Autor:
Kevin C. Allan, Tyler E. Miller, Andrew R. Morton, Marissa A. Scavuzzo, Matthew S. Elitt, Benjamin L.L. Clayton, Lucille R. Hu, Jost K. Vrabic, Hannah E. Olsen, Daniel C. Factor, Jonathan E. Henninger, Richard A. Young, Charles Y. Lin, Peter C. Scacheri, Paul J. Tesar
SUMMARYPluripotent stem cells (PSCs) provide an unlimited source for generating somatic cell types. However, generating fully mature cells constitutes a bottleneck for realizing their full potential in research and medicine. Here, we report a transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ee17af1d86d3aea0ee785bea3821dc2
https://doi.org/10.1101/2022.11.17.516981
https://doi.org/10.1101/2022.11.17.516981
Autor:
Ronald A. Conlon, Berit Powers, Matthew S. Elitt, Daniela Schlatzer, H. Elizabeth Shick, Yuka Maeno-Hikichi, Lilianne Barbar, David F. LePage, Weihong Jiang, Hannah E. Olsen, Hien T Zhao, Stevephen Hung, Adam Swayze, Frank Rigo, Paul J. Tesar, Kevin C. Allan, Zachary S. Nevin, Baraa S. Nawash, Masahiro Hitomi, Artur S. Gevorgyan, Mayur Madhavan
Publikováno v:
Nature
Mutations in PLP1, the gene that encodes proteolipid protein (PLP), result in failure of myelination and neurological dysfunction in the X-chromosome-linked leukodystrophy Pelizaeus–Merzbacher disease (PMD)1,2. Most PLP1 mutations, including point
Autor:
Benjamin L.L. Clayton, James D. Kristell, Kevin C. Allan, Molly Karl, Eric Garrison, Yuka Maeno-Hikichi, Annalise M. Sturno, H. Elizabeth Shick, Robert H. Miller, Paul J. Tesar
Disease, injury, and aging induce reactive astrocyte states with pathological functions1-4. In neurodegenerative diseases, inflammatory reactive astrocytes are abundant and contribute to progressive cell loss. Modulating the state or function of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97744fa0614581a8d33f39edd03eb9a9
https://doi.org/10.1101/2021.11.03.467083
https://doi.org/10.1101/2021.11.03.467083
Publikováno v:
Nature communications. 13(1)
Oligodendrocytes are specialized cells that confer neuronal myelination in the central nervous system. Leukodystrophies associated with oligodendrocyte deficits and hypomyelination are known to result when a number of tRNA metabolism genes are mutate
Autor:
Caitlin Carlton, Guy Baratz, Gabrielle E. Rieth, Amy L. Wilson-Delfosse, Rubina Ratnaparkhi, Bryan M Singelyn, Kevin C. Allan, Brenden P Jenks, Barbara Kent Freeman, Susanne Wish-Baratz
Publikováno v:
Med Sci Educ
The purpose of this study was to compare the effectiveness and qualitative experience of learning gross anatomy of the pelvis and perineum (P/P) and musculoskeletal system (MSK) via cadaveric dissection to learning these same anatomical regions using