Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kevin C Flynn"'
Autor:
Diana Raju, Sophie Schonauer, Hussein Hamzeh, Kevin C Flynn, Frank Bradke, Katharina Vom Dorp, Peter Dörmann, Yildiz Yildiz, Christian Trötschel, Ansgar Poetsch, Bernadette Breiden, Konrad Sandhoff, Heinz G Körschen, Dagmar Wachten
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005063 (2015)
Glycosphingolipids are key elements of cellular membranes, thereby, controlling a variety of cellular functions. Accumulation of the simple glycosphingolipid glucosylceramide results in life-threatening lipid storage-diseases or in male infertility.
Externí odkaz:
https://doaj.org/article/84518ab1fa044772b1427f7ce8368369
Autor:
Xi Lu, Eli Perr, Tahmina Naqvi, David Galitz, Marnelle Andersen, David Grabowski, Anthony Person, Alex Kalyuzhny, Kevin C. Flynn
Publikováno v:
Cells, Vol 13, Iss 18, p 1566 (2024)
An essential aspect of harnessing the potential of pluripotent stem cells (PSCs) and their derivatives for regenerative medicine is the development of animal-free and chemically defined conditions for ex vivo cultivation. PSCs, including embryonic an
Externí odkaz:
https://doaj.org/article/bd86ffcb4639422b91d9ac7d86690cd0
Autor:
Kevin C. Flynn, Frank Bradke
Publikováno v:
Cellular Migration and Formation of Axons and Dendrites ISBN: 9780128144077
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::284c5e0d330971dfd3d8742bbd63bc0a
https://doi.org/10.1016/b978-0-12-814407-7.00002-x
https://doi.org/10.1016/b978-0-12-814407-7.00002-x
Autor:
François Beaubien, Franck Bielle, Frank Bradke, Frédéric Charron, Alain Chédotal, Jean-François Cloutier, Christopher L. Cunningham, Fernando de Castro, Kevin C. Flynn, Fernando García-Moreno, Sonia Garel, R.J. Giger, Wesley B. Grueber, K. Hayashi, Zhigang He, Holden Higginbotham, Katrine Iversen, Artur Kania, Eyal Karzbrun, Arnold R. Kriegstein, Zeljka Krsnik, Christophe Laumonnerie, Julie L. Lefebvre, Fanny Lepiemme, Guangnan Li, Joseph J. LoTurco, Le Ma, Jean-Bernard Manent, Julie Marocha, Zoltán Molnár, K. Nakajima, Laurent Nguyen, Stephen C. Noctor, Hirofumi Noguchi, R. Jeroen Pasterkamp, Samuel J. Pleasure, F. Polleux, Tatiana Popovitchenko, Janet E.A. Prince, Mladen-Roko Rasin, Orly Reiner, Masato Sawada, Kazunobu Sawamoto, K. Sekine, Carla Silva G., David J. Solecki, Constantino Sotelo, H. Tabata, Marc Tessier-Lavigne, Stephen R. Tymanskyj, Marieke G. Verhagen, Fan Wang, Franco Weth, Patricia T. Yam, Jing Yang, Bing Ye, Bernard Zalc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a429aec418543056aa632fc00d08e406
https://doi.org/10.1016/b978-0-12-814407-7.01002-6
https://doi.org/10.1016/b978-0-12-814407-7.01002-6
Autor:
Sina Stern, Kevin C. Flynn, Michele Curcio, Walter Witke, Brett J. Hilton, Christine B. Gurniak, Frank Bradke, Barbara Schaffran, Molly J.E. Larson, Claudia J. Laskowski, Sebastian Dupraz, Andrea Tedeschi, Telma E. Santos
Publikováno v:
Neuron 103(6), 1073-1085.e6 (2019). doi:10.1016/j.neuron.2019.07.007
Summary Injured axons fail to regenerate in the adult CNS, which contrasts with their vigorous growth during embryonic development. We explored the potential of re-initiating axon extension after injury by reactivating the molecular mechanisms that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07de3102c075dac51ac6dc9b6a076d7
https://pubmed.ncbi.nlm.nih.gov/31557454
https://pubmed.ncbi.nlm.nih.gov/31557454
Autor:
Oliver Brüstle, Kevin C. Flynn, Jörg Ruschel, Michael Peitz, John L. Bixby, David A. Elliott, Norbert Weidner, Christopher Sliwinski, Mary Bartlett Bunge, Gary A. Brook, Frank Bradke, Kristina Dobrindt, Margaret L. Bates, Andrea Tedeschi, Sebastian Dupraz, Armin Blesch, Farida Hellal, Michael D. Norenberg
Publikováno v:
Science. 348:347-352
Progress toward fixing a broken back? Axon regeneration after a spinal cord injury requires interference with neuronal mechanisms to promote axon extension and early suppression of scar formation. Microtubule stabilization could provide, in principle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51fbf753edc9aa46272fb778a3400556
https://doi.org/10.1126/science.aaa2958
https://doi.org/10.1126/science.aaa2958
Autor:
James R. Bamburg, Kevin C. Flynn, Miguel Santiago-Medina, Bonnie M. Marsick, Paul C. Letourneau
Publikováno v:
Developmental Neurobiology. 70:565-588
Proper neural circuitry requires that growth cones, motile tips of extending axons, respond to molecular guidance cues expressed in the developing organism. However, it is unclear how guidance cues modify the cytoskeleton to guide growth cone pathfin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a0911b8d3c115e8127211d0670548c
https://doi.org/10.1002/dneu.20800
https://doi.org/10.1002/dneu.20800
Autor:
Sabina Tahirovic, Frank Bradke, Dorothee Neukirchen, Kevin C. Flynn, Boyan K. Garvalov, Anna Chrostek-Grashoff, Cord Brakebusch, Theresia E. B. Stradal, Robert Hindges, Farida Hellal
Publikováno v:
The Journal of Neuroscience. 30:6930-6943
Neuronal migration and axon growth, key events during neuronal development, require distinct changes in the cytoskeleton. Although many molecular regulators of polarity have been identified and characterized, relatively little is known about their ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d618296280977b6c9b6b34b4d95d86
https://doi.org/10.1523/jneurosci.5395-09.2010
https://doi.org/10.1523/jneurosci.5395-09.2010
Autor:
J. R. Jensen, James R. Bamburg, Alisa E. Shaw, Michael T. Maloney, Ian T. Marsden, Barbara W. Bernstein, Kevin C. Flynn, Claire Goldsbury, Ineka T. Whiteman, O'Neil Wiggan, Laurie S. Minamide, Richard C. Davis, Chi W. Pak
Publikováno v:
Current Alzheimer Research. 7:241-250
Dephosphorylation (activation) of cofilin, an actin binding protein, is stimulated by initiators of neuronal dysfunction and degeneration including oxidative stress, excitotoxic glutamate, ischemia, and soluble forms of beta-amyloid peptide (Abeta).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a071efc112c289a2f9c07570dc9d82b1
https://doi.org/10.2174/156720510791050902
https://doi.org/10.2174/156720510791050902
Publikováno v:
Developmental Neurobiology. 69:761-779
Axonogenesis involves a shift from uniform delivery of materials to all neurites to preferential delivery to the putative axon, supporting its more rapid extension. Waves, growth cone-like structures that propagate down the length of neurites, were s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4596b4be96e46b33a5b5d5738bd76a59
https://doi.org/10.1002/dneu.20734
https://doi.org/10.1002/dneu.20734