Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kevin C, Ludwig"'
Autor:
Fabian Grein, Anna Müller, Katharina M. Scherer, Xinliang Liu, Kevin C. Ludwig, Anna Klöckner, Manuel Strach, Hans-Georg Sahl, Ulrich Kubitscheck, Tanja Schneider
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The mechanism of action of daptomycin, a lipopeptidic antibiotic, is unclear. Here, the authors show that Ca2+-daptomycin simultaneously interacts with lipid-coupled precursors of the bacterial cell envelope and with the anionic phospholipid phosphat
Externí odkaz:
https://doaj.org/article/3f8afa07193d465fb47aa48692257131
Autor:
Selvi C. Ersoy, Liana C. Chan, Michael R. Yeaman, Henry F. Chambers, Richard A. Proctor, Kevin C. Ludwig, Tanja Schneider, Adhar C. Manna, Ambrose Cheung, Arnold S. Bayer
Publikováno v:
Antibiotics, Vol 11, Iss 4, p 462 (2022)
Methicillin-resistant Staphylococcus aureus (MRSA) regulates resistance to β-lactams via preferential production of an alternative penicillin-binding protein (PBP), PBP2a. PBP2a binds many β-lactam antibiotics with less affinity than PBPs which are
Externí odkaz:
https://doaj.org/article/329a3c32a6454aac89e76ce5f344b0ce
Autor:
Matthew Drayton, Julia P. Deisinger, Kevin C. Ludwig, Nigare Raheem, Anna Müller, Tanja Schneider, Suzana K. Straus
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11172 (2021)
The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial infections to become a global health concern. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), offer a viable solution to these pathogens d
Externí odkaz:
https://doaj.org/article/69d959c808554142a92f92c0c56d924e
Autor:
Rhythm Shukla, Aaron J. Peoples, Kevin C. Ludwig, Sourav Maity, Maik G.N. Derks, Stefania de Benedetti, Annika M Krueger, Bram J.A. Vermeulen, Francesca Lavore, Rodrigo V. Honorato, Fabian Grein, Alexandre Bonvin, Ulrich Kubitscheck, Eefjan Breukink, Catherine Achorn, Anthony Nitti, Christopher J. Schwalen, Amy L. Spoering, Losee Lucy Ling, Dallas Hughes, Moreno Lelli, Wouter H. Roos, Kim Lewis, Tanja Schneider, Markus Weingarth
Publikováno v:
bioRxiv
SummaryAntimicrobial resistance is a leading mortality factor worldwide. Here we report the discovery of clovibactin, a new antibiotic, isolated from uncultured soil bacteria. Clovibactin efficiently kills drug-resistant bacterial pathogens without d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a194cd4955538bc1ed55a40015678a
https://europepmc.org/articles/PMC10245560/
https://europepmc.org/articles/PMC10245560/
Autor:
Max Crüsemann, Daniel A. Wirtz, Aaron J. Peoples, Anthony Nitti, Gabriele M. König, Michaele Josten, Beate Henrichfreise, Kevin C Ludwig, Stefan Kehraus, Carina E Marx, Sebastian Krannich, Melina Arts, Kim Lewis, Paul Barac, Amy Spoering, Tanja Schneider, Losee L Ling, Anna Müller
Publikováno v:
Angewandte Chemie (International Ed. in English)
Hypeptin is a cyclodepsipeptide antibiotic produced by Lysobacter sp. K5869, isolated from an environmental sample by the iChip technology, dedicated to the cultivation of previously uncultured microorganisms. Hypeptin shares structural features with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312e1e6fb2d0009a8736d4d61b670282
https://doi.org/10.1002/anie.202102224
https://doi.org/10.1002/anie.202102224
Autor:
Selvi C, Ersoy, Liana C, Chan, Michael R, Yeaman, Henry F, Chambers, Richard A, Proctor, Kevin C, Ludwig, Tanja, Schneider, Adhar C, Manna, Ambrose, Cheung, Arnold S, Bayer
Publikováno v:
Antibiotics (Basel, Switzerland). 11(4)
Methicillin-resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7d378ee67ff454c31cb78b7f7ba08cd
https://pubmed.ncbi.nlm.nih.gov/35453214
https://pubmed.ncbi.nlm.nih.gov/35453214
Autor:
Fredrik Almqvist, Priyanka Nannapaneni, Tanja Schneider, Hanna Uvell, Anna Eriksson, Elisabeth Reithuber, Anders E. G. Lindgren, Birgitta Henriques-Normark, Sandra Muschiol, Anna Müller, Peter Mellroth, Kevin C. Ludwig, Fabian Grein, Staffan Normark, Torbjörn Wixe
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Considering the alarming emergence of resistance to most antibiotics and the need for new antibiotics, the finding here of a small-molecule class, THCz, that displayed bactericidal activity against gram-positive and selected gram-negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c90680bd76adf39525fff323412542
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191611
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191611
Autor:
Fabian, Grein, Anna, Müller, Katharina M, Scherer, Xinliang, Liu, Kevin C, Ludwig, Anna, Klöckner, Manuel, Strach, Hans-Georg, Sahl, Ulrich, Kubitscheck, Tanja, Schneider
Publikováno v:
Nature Communications
The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug-resistant enterococci. Its precise mechanism of action is incompletely un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5e3bc2b66284bb85d58832cecb14ec8
https://pubmed.ncbi.nlm.nih.gov/32193379
https://pubmed.ncbi.nlm.nih.gov/32193379
Publikováno v:
ACS chemical biology. 14(5)
Ribosomally synthesized post-translationally modified peptides (RiPPs) are a diverse class of biologically active molecules produced by many environmental bacteria. While thousands of these compounds have been identified, mostly through genome mining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cc4411e07676cc4ee2805316726c56
https://pubmed.ncbi.nlm.nih.gov/31026131
https://pubmed.ncbi.nlm.nih.gov/31026131
Autor:
Wirtz, Daniel A.1 (AUTHOR), Ludwig, Kevin C.2,3 (AUTHOR), Arts, Melina2 (AUTHOR), Marx, Carina E.2 (AUTHOR), Krannich, Sebastian2 (AUTHOR), Barac, Paul1 (AUTHOR), Kehraus, Stefan1 (AUTHOR), Josten, Michaele3,4 (AUTHOR), Henrichfreise, Beate2 (AUTHOR), Müller, Anna2 (AUTHOR), König, Gabriele M.1 (AUTHOR), Peoples, Aaron J.5 (AUTHOR), Nitti, Anthony5 (AUTHOR), Spoering, Amy L.5 (AUTHOR), Ling, Losee L.5 (AUTHOR), Lewis, Kim6 (AUTHOR), Crüsemann, Max1 (AUTHOR) mcruesem@uni-bonn.de, Schneider, Tanja2 (AUTHOR) tschneider@uni-bonn.de
Publikováno v:
Angewandte Chemie. 6/7/2021, Vol. 133 Issue 24, p13691-13698. 8p.