Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kevin C, Crosby"'
Autor:
Samantha S. Olah, Dean J. Kareemo, William C. Buchta, Brooke L. Sinnen, Carley N. Miller, Hannah S. Actor-Engel, Sara E. Gookin, Christina S. Winborn, Mason S. Kleinjan, Kevin C. Crosby, Jason Aoto, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113331- (2023)
Summary: Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites. While spatial coordination between pre- and postsynaptic elemen
Externí odkaz:
https://doaj.org/article/3444965cf8894b45b28692c79eca5faf
Autor:
Harrison J. Ramsay, Sara E. Gookin, Austin M. Ramsey, Dean J. Kareemo, Kevin C. Crosby, Dominik G. Stich, Samantha S. Olah, Hannah S. Actor-Engel, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses. Intriguingly, postsynapt
Externí odkaz:
https://doaj.org/article/0a611978cc574cd884372c1cb950f914
Autor:
Xiaobing Chen, Kevin C. Crosby, Austin Feng, Alicia M. Purkey, Maria A. Aronova, Christine A. Winters, Virginia T. Crocker, Richard D. Leapman, Thomas S. Reese, Mark L. Dell’Acqua
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
A-kinase anchoring protein 79-human/150-rodent (AKAP79/150) organizes signaling proteins to control synaptic plasticity. AKAP79/150 associates with the plasma membrane and endosomes through its N-terminal domain that contains three polybasic regions
Externí odkaz:
https://doaj.org/article/4c26f9a0611f46cbba8fda88c1d0d6a0
Autor:
Sara E. Gookin, Matthew R. Taylor, Samantha L. Schwartz, Matthew J. Kennedy, Mark L. Dell’Acqua, Kevin C. Crosby, Katharine R. Smith
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
The nanoscale architecture of synapses has been investigated using multiple super-resolution methods, revealing a common modular structure for scaffolds, neurotransmitter receptors, and presynaptic proteins. This fundamental organization of proteins
Externí odkaz:
https://doaj.org/article/ce3db4c3150a42509ceaf51515256aad
Autor:
Carolyn Nicole Brown, Sarah G. Cook, Hillary F. Allen, Kevin C. Crosby, Tarjinder Singh, Steven J. Coultrap, K. Ulrich Bayer
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103184- (2021)
Summary: The Ca2+/Calmodulin-dependent protein kinase II (CaMKII) is a central regulator of synaptic plasticity and has been implicated in various neurological conditions, including schizophrenia. Here, we characterize six different CaMKIIα variants
Externí odkaz:
https://doaj.org/article/99bee0eeeb324359bf2282e2f6ae69cf
Autor:
Kevin C. Crosby, Sara E. Gookin, Joshua D. Garcia, Katlin M. Hahm, Mark L. Dell’Acqua, Katharine R. Smith
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3284-3297.e3 (2019)
Summary: Inhibitory synapses mediate the majority of synaptic inhibition in the brain, thereby controlling neuronal excitability, firing, and plasticity. Although essential for neuronal function, the central question of how these synapses are organiz
Externí odkaz:
https://doaj.org/article/177e5de8518b4b4f9459c49e82a08221
Autor:
Alicia M. Purkey, Kevin M. Woolfrey, Kevin C. Crosby, Dominik G. Stich, Wallace S. Chick, Jason Aoto, Mark L. Dell’Acqua
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 974-987.e4 (2018)
Summary: Ca2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term potentiation (LTP), but mechanisms regulating CP-AMPARs are poorly
Externí odkaz:
https://doaj.org/article/5cfe45e1aa0144229d4b3260ef3ae995
Autor:
Jonathan I. Watkinson, Peter A. Bowerman, Kevin C. Crosby, Sherry B. Hildreth, Richard F. Helm, Brenda S.J. Winkel
Publikováno v:
PeerJ, Vol 6, p e5598 (2018)
Plant flavonoid metabolism has served as a platform for understanding a range of fundamental biological phenomena, including providing some of the early insights into the subcellular organization of metabolism. Evidence assembled over the past three
Externí odkaz:
https://doaj.org/article/f6182f6662fa4b2abbd542e760bd909d
Autor:
Jennifer N. Bourne, Samantha L Schwartz, Olga Prikhodko, Alexandra Lucas, Kevin C. Crosby, Harrison J. Ramsay, Christina S. Winborn, Brooke L. Sinnen, Hannah S. Actor-Engel, Mark L. Dell'Acqua, Katherine R. Smith, Matthew J. Kennedy
Publikováno v:
eNeuro
Secreted amyloid-β (Aβ) peptide forms neurotoxic oligomeric assemblies thought to cause synaptic deficits associated with Alzheimer's disease (AD). Soluble Aβ oligomers (Aβo) directly bind to neurons with high affinity and block plasticity mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3cd662ac39a6426dae965e984308ba
https://pubmed.ncbi.nlm.nih.gov/34789478
https://pubmed.ncbi.nlm.nih.gov/34789478
Autor:
Mark L. Dell'Acqua, Jonathan G. Murphy, William A. Sather, Kevin C. Crosby, Philip J. Dittmer
Publikováno v:
Molecular Biology of the Cell. 30:1743-1756
In neurons, regulation of activity-dependent transcription by the nuclear factor of activated T-cells (NFAT) depends upon Ca2+influx through voltage-gated L-type calcium channels (LTCC) and NFAT translocation to the nucleus following its dephosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fe94fa58c4becb763045fcc8267720a
https://doi.org/10.1091/mbc.e19-01-0060
https://doi.org/10.1091/mbc.e19-01-0060