A population genetic interpretation of GWAS findings for human quantitative traits.

Autor: Yuval B Simons, Kevin Bullaughey, Richard R Hudson, Guy Sella

Publikováno v: PLoS Biology, Vol 16, Iss 3, p e2002985 (2018)

Human genome-wide association studies (GWASs) are revealing the genetic architecture of anthropomorphic and biomedical traits, i.e., the frequencies and effect sizes of variants that contribute to heritable variation in a trait. To interpret these fi

Externí odkaz: https://doaj.org/article/5d63b90bf6e4402c94cdd11d404ea3ad

Contribution of transcription factor binding site motif variants to condition-specific gene expression patterns in budding yeast.

Autor: Joshua S Rest, Kevin Bullaughey, Geoffrey P Morris, Wen-Hsiung Li

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32274 (2012)

It is now experimentally well known that variant sequences of a cis transcription factor binding site motif can contribute to differential regulation of genes. We characterize the relationship between motif variants and gene expression by analyzing e

Externí odkaz: https://doaj.org/article/f0b36e2ab55944a9a08fb3f01a83d069

Nonlinear Fitness Consequences of Variation in Expression Level of a Eukaryotic Gene

Autor: Julius Fisher, Demitri Dedousis, Joshua S. Rest, Kevin Bullaughey, Seungjae Moon, Lucas B. Carey, Dana A. Opulente, John B. Waldron, Christopher M. Morales

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Molecular Biology and Evolution

Levels of gene expression show considerable variation in eukaryotes, but no fine-scale maps have been made of the fitness consequences of such variation in controlled genetic backgrounds and environments. To address this, we assayed fitness at many l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e572c5e9e837d9b365bcdaed801f907b
https://doi.org/10.1093/molbev/mss248

Changes in Selective Effects Over Time Facilitate Turnover of Enhancer Sequences

Autor: Kevin Bullaughey

Publikováno v: Genetics. 187:567-582

Correct gene expression is often critical and consequently stabilizing selection on expression is widespread. Yet few genes possess highly conserved regulatory DNA, and for the few enhancers that have been carefully characterized, substantial functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800097e6e5b08eb35515e2f8ef0f7231
https://doi.org/10.1534/genetics.110.121590

Revisiting an old riddle: what determines genetic diversity levels within species?

Autor: Daniel R. Matute, Peter Andolfatto, Kevin Bullaughey, Ellen M. Leffler, Wynn K. Meyer, Aarti Venkat, Laure Ségurel, Molly Przeworski

Publikováno v: PLoS Biology, Vol 10, Iss 9, p e1001388 (2012)
PLoS Biology
PLoS Biology, Public Library of Science, 2012, 10 (9), pp.e1001388. ⟨10.1371/journal.pbio.1001388⟩

With the recent revolution in sequencing, we revisit the unresolved question of what influences the range and values of genetic diversity across taxa.
Understanding why some species have more genetic diversity than others is central to the study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7691a37f0d44c6ba1a95b1d2e36b0b4f
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22984349/pdf/?tool=EBI