Calcium Microdomain Formation at the Perisynaptic Cradle Due to NCX Reversal: A Computational Study

Autor: John Joseph Wade, Kevin Breslin, KongFatt Wong-Lin, Jim Harkin, Bronac Flanagan, Harm Van Zalinge, Steve Hall, Mark Dallas, Angela Bithell, Alexei Verkhratsky, Liam McDaid

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)

It has recently been proposed using a multi-compartmental mathematical model that negatively fixed charged membrane-associated sites constrain the flow of cations in perisynaptic astroglial processes. This restricted movement of ions between the peri

Externí odkaz: https://doaj.org/article/6f9a5fe56ae645eb8d7273839596f72c

Potassium and sodium microdomains in thin astroglial processes: A computational model study

Autor: Jim Harkin, John Wade, Liam McDaid, Harm van Zalinge, Bronac Flanagan, Alexei Verkhratsky, Kevin Breslin, Matthew C. Walker, Steve Hall, KongFatt Wong-Lin

Publikováno v: PLoS Computational Biology, Vol 14, Iss 5, p e1006151 (2018)
PLoS Computational Biology
Breslin, K, Wade, J J, Wong-lin, K, Harkin, J, Flanagan, B, Van Zalinge, H, Hall, S, Walker, M, Verkhratsky, A, Mcdaid, L & Jolivet, R B (ed.) 2018, ' Potassium and sodium microdomains in thin astroglial processes: A computational model study ', PLoS computational biology, vol. 14, no. 5 . https://doi.org/10.1371/journal.pcbi.1006151

A biophysical model that captures molecular homeostatic control of ions at the perisynaptic cradle (PsC) is of fundamental importance for understanding the interplay between astroglial and neuronal compartments. In this paper, we develop a multi-comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e733c00935f9476ec01c4692d3ee3c
http://europepmc.org/articles/PMC5979043?pdf=render