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High-Throughput Generation of Bipod (Fab × scFv) Bispecific Antibodies Exploits Differential Chain Expression and Affinity Capture

Autor: Christine Springer, Adam Zwolak, Haiyan Jiang, Thomas C. Nesspor, Sanjaya Singh, Gordon Powers, Nicholas Mazzanti, Justin Sprenkle, Sherry L. La Porte, Kyle Kinealy, Michael D. Diem, Kevin Boye, Rajkumar Ganesan, Hunter Hoffman

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports

Generation of bispecific antibodies (BsAbs) having two unique Fab domains requires heterodimerization of the two heavy chains and pairing of each heavy chain with its cognate light chain. An alternative bispecific scaffold (Bipod) comprising an scFv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b20b1118aeab23ef074f3ba6fb10c72
https://doi.org/10.1038/s41598-020-64536-w

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Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles

Autor: Kevin Boye, Lauren Anderson-Pullinger, Felix Boos, Carmen Bekeova, Johannes M. Herrmann, Erin L. Seifert, Yana Sharpadskaya

Publikováno v: J Biol Chem

Acyl-CoA thioesterases (Acots) hydrolyze fatty acyl-CoA esters. Acots in the mitochondrial matrix are poised to mitigate β-oxidation overload and maintain CoA availability. Several Acots associate with mitochondria, but whether they all localize to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcd0af025e76eaf3d293f90706212a9
https://pubmed.ncbi.nlm.nih.gov/31676684

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Multiple acyl-CoA thioesterases occupy distinct functional niches within the mitochondrial matrix

Autor: Carmen Bekeova, Erin L. Seifert, Johannes M. Herrmann, Kevin Boye, Felix Boos, Lauren Anderson-Pullinger, Yana Sharpadskaya

SUMMARYAcyl-CoA thioesterases (Acots) hydrolyze fatty acyl-CoA esters. Acots in the mitochondrial matrix are poised to mitigate β-oxidation overload that may contribute to lipotoxicity. Several Acots associate with mitochondria, but whether they all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216569c1b62491ec17c8ebff19da8568