Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kevin Bode"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type 1 diabetes (T1D) arises from autoimmune-mediated destruction of insulin-producing pancreatic beta cells. Recent advancements in the technology of generating pancreatic beta cells from human pluripotent stem cells (SC-beta cells) have facilitated
Externí odkaz:
https://doaj.org/article/ef7d93fd837c46f9bf4b266d6a3d535f
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102795- (2023)
Reactive oxygen species (ROS) are a family of highly reactive molecules with numerous, often pleiotropic functions within the cell and the organism. Due to their potential to destroy biological structures such as membranes, enzymes and organelles, RO
Externí odkaz:
https://doaj.org/article/9f021b51498341d9aeba2ba031b3da09
Publikováno v:
Bio-Protocol, Vol 10, Iss 17 (2020)
Depending on its concentration and cellular origin the production of reactive oxygen species (ROS) in the organism serves a variety of functions. While high concentrations during an oxidative burst are used to fight pathogens, low to moderate amounts
Externí odkaz:
https://doaj.org/article/010f935a710f4284abebc7af83d91400
Autor:
Kevin Bode, Fatmire Bujupi, Corinna Link, Tobias Hein, Stephanie Zimmermann, Diluka Peiris, Vincent Jaquet, Bernd Lepenies, Heiko Weyd, Peter H. Krammer
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4435-4446.e9 (2019)
Summary: Uptake of apoptotic cells (ACs) by dendritic cells (DCs) and induction of a tolerogenic DC phenotype is an important mechanism for establishing peripheral tolerance to self-antigens. The receptors involved and underlying signaling pathways a
Externí odkaz:
https://doaj.org/article/31132c112ccb4eda9e7c9bb04dcb514c
Autor:
Kevin Bode, Tara MacDonald, Taylor Stewart, Bryhan Mendez, Erica P. Cai, Noelle Morrow, Yu-Chi Lee, Peng Yi, Stephan Kissler
Publikováno v:
Diabetes.
Type 1 diabetes (T1D) is caused by the immune-mediated loss of pancreatic beta cells that produce insulin. The latest advances in stem cell (SC)-beta cell differentiation methods have made a cell replacement therapy for T1D feasible. However, recurri
Autor:
Stephan Kissler, Peng Yi, Yu-Chi Lee, Noelle Morrow, Erica P. Cai, Bryhan Mendez, Taylor Stewart, Tara MacDonald, Kevin Bode
Type 1 diabetes (T1D) is caused by the immune-mediated loss of pancreatic beta cells that produce insulin. The latest advances in stem cell (SC)-beta cell differentiation methods have made a cell replacement therapy for T1D feasible. However, recurri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab250618349bd5772c3a1ed9c97edd3
https://doi.org/10.2337/figshare.22898705.v1
https://doi.org/10.2337/figshare.22898705.v1
Publikováno v:
bioRxiv
Regulatory T cells (Tregs) protect against autoimmunity. In type 1 diabetes (T1D), Tregs slow the progression of beta cell autoimmunity within pancreatic islets. Increasing the potency or frequency of Tregs can prevent diabetes, as evidenced by studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de6d2f1abe23094986f6f143bfa3688
https://doi.org/10.1101/2023.03.18.533297
https://doi.org/10.1101/2023.03.18.533297
Publikováno v:
Journal of Visualized Experiments.
Type 1 diabetes is characterized by the autoimmune destruction of the insulin-producing beta cells of the pancreas. A promising treatment for this disease is the transplantation of stem cell-derived beta cells. Genetic modifications, however, may be
Autor:
Stephanie Zimmermann, Corinna Link, Tobias Hein, Bernd Lepenies, Vincent Jaquet, Peter H. Krammer, Diluka Peiris, Heiko Weyd, Fatmire Bujupi, Kevin Bode
Publikováno v:
Cell Reports
Cell Reports, Vol 29, Iss 13, Pp 4435-4446.e9 (2019)
Cell Reports, Vol 29, Iss 13, Pp 4435-4446.e9 (2019)
Summary: Uptake of apoptotic cells (ACs) by dendritic cells (DCs) and induction of a tolerogenic DC phenotype is an important mechanism for establishing peripheral tolerance to self-antigens. The receptors involved and underlying signaling pathways a