Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kevin Blades"'
Autor:
Adam O. Whelan, Ian Cooper, Nicola Ooi, David Orr, Kevin Blades, James Kirkham, Amanda Lyons, Kay B. Barnes, Mark I. Richards, Anne-Marie Salisbury, Mark Craighead, Sarah V. Harding
Publikováno v:
Antibiotics, Vol 12, Iss 6, p 983 (2023)
Antimicrobial resistance is a global issue, and the investigation of alternative therapies that are not traditional antibiotics are warranted. Novel bacterial type II topoisomerase inhibitors (NBTIs) have recently emerged as a novel class of antibiot
Externí odkaz:
https://doaj.org/article/6d05f97764de41768e12f6520ccf2f5f
Autor:
Alex Swann, Roger Tan, Matthew Harper, Kevin Blades, Zacharia Joseph, Nicholas Calvert, Michael Salmon, Piers Yates
Publikováno v:
J Orthop
AIMS: There is very little published literature on Enhanced Recovery Principles (ERP) used in primary joint replacements applied to revision hip and knee arthroplasty (rTHA, rTKA). METHODS: Retrospective series of 268 rTHA and rTKA surgeries from 201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae6cd9ca513bbf407d515d467e671ad
https://doi.org/10.1016/j.jor.2020.11.004
https://doi.org/10.1016/j.jor.2020.11.004
Autor:
Amanda Lyons, James Kirkham, Kevin Blades, David Orr, Elizabeth Dauncey, Oliver Smith, Emma Dick, Rolf Walker, Teresa Matthews, Adam Bunt, Jonathan Finlayson, Ian Morrison, Victoria J. Savage, Emmanuel Moyo, Hayley S. Butler, Rebecca Newman, Nicola Ooi, Andrew Smith, Cédric Charrier, Andrew J. Ratcliffe, Neil R. Stokes, Stuart Best, Anne-Marie Salisbury, Mark Craighead, Ian R. Cooper
Publikováno v:
Bioorganicmedicinal chemistry letters. 65
There is an increasingly urgent and unmet medical need for novel antibiotic drugs that tackle infections caused by multidrug-resistant (MDR) pathogens. Novel bacterial type II topoisomerase inhibitors (NBTIs) are of high interest due to limited cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da721e70bec2ab77ddb3d96dcd4b4616
https://pubmed.ncbi.nlm.nih.gov/35231579
https://pubmed.ncbi.nlm.nih.gov/35231579
Autor:
Philip J. Jewsbury, Rajesh Odedra, Alan Lau, Sylvie Guichard, James W.T. Yates, Kevin Blades, Gary Wilkinson, Kevin Michael Foote, Dan Heathcote, Turner Paul, Christine M. Wood, J. Willem M. Nissink, Zena Wilson, Thomas M. McGuire
Publikováno v:
Journal of Medicinal Chemistry. 61:9889-9907
The kinase ataxia telangiectasia mutated and rad3 related (ATR) is a key regulator of the DNA-damage response and the apical kinase which orchestrates the cellular processes that repair stalled replication forks (replication stress) and associated DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59401034970f33d8440158f4ed912d1
https://doi.org/10.1021/acs.jmedchem.8b01187
https://doi.org/10.1021/acs.jmedchem.8b01187
Autor:
Gordon S. Currie, Kurt Gordon Pike, Janet D. Culshaw, Martin Pass, Kristy Gill, M. Raymond V. Finlay, Stuart E. Pearson, Jonathan M. Eden, Craig A. Roberts, Linette Ruston, Kevin Blades, Sarah L. Pass, Catherine Good, Ryan Greenwood, Morris Jeffrey James, Julie Demeritt, Emma J. Williams
Publikováno v:
Journal of Medicinal Chemistry. 58:2326-2349
High throughput screening followed by a lead generation campaign uncovered a novel series of urea containing morpholinopyrimidine compounds which act as potent and selective dual inhibitors of mTORC1 and mTORC2. We describe the continued compound opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d03d7044c1623334474876e879b938a
https://doi.org/10.1021/jm501778s
https://doi.org/10.1021/jm501778s
Publikováno v:
Synlett. 26:228-232
We report an efficient synthesis of the novel 1,4,6,7-tetrahydropyrazolo[3,4-c]pyridin-5-one scaffold with the potential for incorporation of alkyl or aryl substituents at the C-3 and N-6 positions. The route utilises a Dieckmann condensation to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::179cdfc16f78b2d8573cc6b3d9fb0228
https://doi.org/10.1055/s-0034-1379504
https://doi.org/10.1055/s-0034-1379504
Autor:
Steven C. Glossop, Kevin Blades
Publikováno v:
Synthesis. 49:554-556
An efficient high-yielding three-step synthesis of N-8-(2,2-dimethoxyethyl)-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one is reported. The route utilises a Heck coupling as the key step.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ecbc187a981be7817d11cc2f54b3e20
https://doi.org/10.1055/s-0036-1588364
https://doi.org/10.1055/s-0036-1588364
Introduction This is the first study reporting the application of Enhanced Recovery Principles (ERP) to revision arthroplasty. Method Retrospective series of 132 revision hip and knee replacements treated with ERP. Results Infiltration was associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89081a90ad955c30ca89c96fa2962e49
https://europepmc.org/articles/PMC5581381/
https://europepmc.org/articles/PMC5581381/
Autor:
William McCoull, Roman D. Abrams, Erica Anderson, Kevin Blades, Peter Barton, Matthew Box, Jonathan Burgess, Kate Byth, Qing Cao, Claudio Chuaqui, Rodrigo J. Carbajo, Tony Cheung, Erin Code, Andrew D. Ferguson, Shaun Fillery, Nathan O. Fuller, Eric Gangl, Ning Gao, Matthew Grist, David Hargreaves, Martin R. Howard, Jun Hu, Paul D. Kemmitt, Jennifer E. Nelson, Nichole O’Connell, D. Bryan Prince, Piotr Raubo, Philip B. Rawlins, Graeme R. Robb, Junjie Shi, Michael J. Waring, David Whittaker, Marta Wylot, Xiahui Zhu
Publikováno v:
Journal of medicinal chemistry. 60(14)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12514db8153b02f098ea628197abde3c
https://pubmed.ncbi.nlm.nih.gov/28485934
https://pubmed.ncbi.nlm.nih.gov/28485934
Autor:
Jennifer E. Nelson, Graeme R. Robb, Martin R. Howard, Piotr Raubo, Paul D. Kemmitt, Kevin Blades, Junjie Shi, Tony Cheung, Qing Cao, Peter Barton, Andrew D. Ferguson, D. Bryan Prince, Shaun M. Fillery, Jun Hu, David J. Hargreaves, Roman D. Abrams, Nathan O. Fuller, Claudio Chuaqui, Eric Gangl, Matthew R. Box, Ning Gao, William McCoull, Kate Byth, Michael J. Waring, Jonathan Burgess, Xiahui Zhu, Matthew Grist, Erica Anderson, Nichole O'Connell, Philip B. Rawlins, Marta Wylot, David Whittaker, Rodrigo J. Carbajo, Erin Code
Publikováno v:
Journal of medicinal chemistry. 60(10)
Inhibition of the protein-protein interaction between B-cell lymphoma 6 (BCL6) and corepressors has been implicated as a therapeutic target in diffuse large B-cell lymphoma (DLBCL) cancers and profiling of potent and selective BCL6 inhibitors are cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208040f32aed94f8aa4f242f2c50c2a7
https://pubmed.ncbi.nlm.nih.gov/28714680
https://pubmed.ncbi.nlm.nih.gov/28714680