Zobrazeno 1 - 10 of 37 pro vyhledávání: '"Kevin Barr"'
1
Akademický článek
Global pannexin 1 deletion increases tumor‐infiltrating lymphocytes in the BRAF/Pten mouse melanoma model
Autor: Rafael E. Sanchez‐Pupo, Garth A. Finch, Danielle E. Johnston, Heather Craig, Rober Abdo, Kevin Barr, Steven Kerfoot, Lina Dagnino, Silvia Penuela
Publikováno v: Molecular Oncology, Vol 18, Iss 4, Pp 969-987 (2024)
Immunotherapies for malignant melanoma seek to boost the anti‐tumoral response of CD8+ T cells, but have a limited patient response rate, in part due to limited tumoral immune cell infiltration. Genetic or pharmacological inhibition of the pannexin
Externí odkaz: https://doaj.org/article/b28427d0e04740b4a538b40b328ea249
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2
Akademický článek
Isolation, Purification, and Culture of Embryonic Melanoblasts from Green Fluorescent Protein–expressing Reporter Mice
Autor: Melissa Crawford, Kevin Barr, Lina Dagnino
Publikováno v: Bio-Protocol, Vol 13, Iss 17 (2023)
In this article, we provide a method to isolate embryonic melanoblasts from reporter mouse strains. The mice from which these cells are isolated are bred into the ROSA26mT/mG reporter background, which results in green fluorescent protein (GFP) expre
Externí odkaz: https://doaj.org/article/ac677553f4f6454e9644a8523748a618
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3
Akademický článek
Mutant Cx30-A88V mice exhibit hydrocephaly and sex-dependent behavioral abnormalities, implicating a functional role for Cx30 in the brain
Autor: Nicole M. Novielli-Kuntz, Eric R. Press, Kevin Barr, Marco A. M. Prado, Dale W. Laird
Publikováno v: Disease Models & Mechanisms, Vol 14, Iss 1 (2021)
Connexin 30 (Cx30; also known as Gjb6 when referring to the mouse gene) is expressed in ependymal cells of the brain ventricles, in leptomeningeal cells and in astrocytes rich in connexin 43 (Cx43), leading us to question whether patients harboring G
Externí odkaz: https://doaj.org/article/121be252cf8e4df59e7baeee4bcc6659
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4
Akademický článek
Comparative Analysis of Cx31 and Cx43 in Differentiation-Competent Rodent Keratinocytes
Autor: Akina Au, Qing Shao, Kyra K. White, Sergiu A. Lucaciu, Jessica L. Esseltine, Kevin Barr, Dale W. Laird
Publikováno v: Biomolecules, Vol 10, Iss 10, p 1443 (2020)
When considering connexin expression and regulation, the epidermis of the skin is one of the most complex tissues found in mammals even though it largely contains a single cell type, the keratinocyte. In the rodent epidermis, up to 9 connexin family
Externí odkaz: https://doaj.org/article/7bfec1a2523344e28e9a65d35467aae5
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5
Discordant growth of nasal cartilage and bone contributes to phenotypic variability of the skull in a mouse model
Autor: Shae A. Book, Alyssa C. Moore, Madeline S. G. Tourigny, Kevin Barr, Katherine E. Willmore
Publikováno v: Developmental Dynamics.
Background: We previously determined a nonlinear relationship between connexin 43 (Cx43) function and craniofacial phenotypic variation in the mutant mouse model G60S/+, and that this variation was driven by nasal bone deviation. While nonlinearities
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ddc2b4d6da19fcd9c5972955c19b8c2
https://doi.org/10.1002/dvdy.584
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7
Pannexin 3 channels regulate architecture, adhesion, barrier function and inflammation in the skin
Autor: Brooke L. O’Donnell, Rafael E. Sanchez-Pupo, Samar Sayedyahossein, Mehdi Karimi, Mehrnoosh Bahmani, Christopher Zhang, Danielle Johnston, John J. Kelly, C. Brent Wakefield, Kevin Barr, Lina Dagnino, Silvia Penuela
The channel-forming glycoprotein Pannexin 3 (PANX3) functions in cutaneous wound healing and keratinocyte differentiation, but its role in skin homeostasis through aging is not yet understood. We found that PANX3 is absent in newborn skin but becomes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::059c67cd5c92d2a30b8e8afc53c8a5cf
https://doi.org/10.1101/2022.07.13.499920
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8
Endothelial Pannexin 3 - B Cell Lymphoma-6 Interactions Protect Against Oxidative Stress
Autor: Abigail G. Wolpe, Melissa A. Luse, Scott R. Johnstone, Jianxiang Xue, Vikram Sabapathy, Brent Wakefield, Rahul Sharma, Kevin Barr, Frank Beier, Dale Laird, Stefanie Redemann, Linda Columbus, Silvia Penuela, Brant E. Isakson
Publikováno v: Paediatrics Publications
Pannexin channel isoforms (Panx1-3) are thought to release nucleotides into the extracellular milieu and have been shown to effect vascular hemodynamics. For this reason, we examined their mRNA and protein expression in hypertensive humans and geneti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35de790385b481a395b6d6aecddd2669
https://ir.lib.uwo.ca/paedpub/762
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10
Interrogation of Carboxy-Terminus Localized GJA1 Variants Associated with Erythrokeratodermia Variabilis et Progressiva
Autor: Sergiu A. Lucaciu, Qing Shao, Rhett Figliuzzi, Kevin Barr, Donglin Bai, Dale W. Laird
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 486
International Journal of Molecular Sciences, Vol 23, Iss 486, p 486 (2022)
International Journal of Molecular Sciences
Neuroscience Institute Publications
Although inherited GJA1 (encoding Cx43) gene mutations most often lead to oculodentodigital dysplasia and related disorders, four variants have been linked to erythrokeratodermia variabilis et progressiva (EKVP), a skin disorder characterized by eryt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7173763065ca0fbd5935a30f8ccbd75
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