Výsledky vyhledávání - "Kevin B. L. Lin"

The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells

Autor: Katharina Rothe, Hanyang Lin, Hui Mi Wang, Mehrnoush Malekesmaeili, Amy Leung, Xiaoyan Jiang, Kevin B. L. Lin, Ryan R. Brinkman, Donna L. Forrest, Sharon M. Gorski

Publikováno v: Blood. 123:3622-3634

Previous studies demonstrated that imatinib mesylate (IM) induces autophagy in chronic myeloid leukemia (CML) and that this process is critical to cell survival upon therapy. However, it is not known if the autophagic process differs at basal levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf75115cbe60d501b6e78561a9e219e7
https://doi.org/10.1182/blood-2013-07-516807

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Identification of a Unique Autophagy Gene Expression Signature in CD34+ CML Stem/Progenitor Cells That Correlates with Clinical Response to Imatinib Mesylate

Autor: Amy Leung, Kevin B. L. Lin, Hanyang Lin, Xiaoyan Jiang, Katharina Rothe, Donna L. Forrest, Sharon M. Gorski

Publikováno v: Blood. 120:1662-1662

Abstract 1662 Chronic myeloid leukemia (CML) stem cells are biologically insensitive to ABL tyrosine kinase inhibitor (TKI) monotherapy and are genetically unstable and rapidly generate imatinib (IM)-resistant mutants in vivo and in vitro. Therefore,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef5d1cbb6ec07a2b0cc50694d16bb131
https://doi.org/10.1182/blood.v120.21.1662.1662

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