Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Kevin B. Ita"'
Publikováno v:
Pharmaceutics, Vol 7, Iss 4, Pp 379-396 (2015)
The aim of this project was to study the influence of microneedles on transdermal delivery of amantadine hydrochloride and pramipexole dihydrochloride across porcine ear skin in vitro. Microchannel visualization studies were carried out and character
Externí odkaz:
https://doaj.org/article/04cff16820604990991bd9c3aa9a7ae0
Publikováno v:
Pharmaceutics, Vol 8, Iss 4, p 33 (2016)
The aim of this project was to examine the effect of microneedle rollers on the percutaneous penetration of tiagabine hydrochloride and carbamazepine across porcine skin in vitro. Liquid chromatography-mass spectrometric analysis was carried out usin
Externí odkaz:
https://doaj.org/article/dc547f24e3944d278dddedf22d4023f7
Autor:
Kevin B. Ita, Sharon Ashong
Publikováno v:
AAPS PharmSciTech. 21
Hypertension remains a significant risk factor for several cardiovascular disorders including coronary artery disease and heart failure. Despite the large armamentarium of drugs available for the management of high blood pressure, low oral availabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c226544a2af67d7117e4ad9d878c023
https://doi.org/10.1208/s12249-019-1583-9
https://doi.org/10.1208/s12249-019-1583-9
Autor:
Kevin B. Ita
Advances in the use of lasers and other ablation techniques for transdermal drug delivery are covered in this chapter. Laser poration involves the utilization of high-energy light source to form well-defined ablated regions in a tissue. When a fracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41c63a08477887b1da65f658b8171f8a
https://doi.org/10.1016/b978-0-12-822550-9.00011-9
https://doi.org/10.1016/b978-0-12-822550-9.00011-9
Autor:
Kevin B. Ita
This chapter examines the application of mathematical modeling to transdermal drug delivery. Several robust mathematical models for describing and predicting percutaneous drug delivery have been developed with the aim of reducing animal experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa79d7db9db446faeb425672cd1cf58a
https://doi.org/10.1016/b978-0-12-822550-9.00012-0
https://doi.org/10.1016/b978-0-12-822550-9.00012-0
Autor:
Kevin B. Ita
The first part of this chapter focuses on the benefits and limitations of transdermal drug delivery systems (TDDSs). Advantages include convenience, avoidance of presystemic metabolism (first-pass effect) and painlessness. Other benefits include noni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0101e10b68e3fb3efc084d9f25388fe2
https://doi.org/10.1016/b978-0-12-822550-9.00001-6
https://doi.org/10.1016/b978-0-12-822550-9.00001-6
Autor:
Kevin B. Ita
The first part of this chapter discusses the principles of transdermal drug delivery. When penetrating the skin via the transcellular route, a drug molecule partitions and diffuses through keratinocytes. There are 4–20 lipid lamellae present betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39f1dade980b184f56fe57c50acd07f7
https://doi.org/10.1016/b978-0-12-822550-9.00003-x
https://doi.org/10.1016/b978-0-12-822550-9.00003-x
Autor:
Kevin B. Ita
Chemical penetration enhancers (CPEs) are examined in this chapter. These compounds enhance transdermal drug delivery by perturbing the stratum corneum (SC) and/or other components of the skin. Skin penetration enhancers may boost SC diffusion coeffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84950ed279a7446201cde86d60608274
https://doi.org/10.1016/b978-0-12-822550-9.00005-3
https://doi.org/10.1016/b978-0-12-822550-9.00005-3
Autor:
Kevin B. Ita
The human skin constitutes a major obstacle to transdermal drug delivery. This chapter examines the anatomy of the skin. The human skin is divided into three layers: the epidermis, dermis, and the subcutaneous layer. The epidermis is a terminally dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb0e9495f70ef7a7860ff4c6563de258
https://doi.org/10.1016/b978-0-12-822550-9.00002-8
https://doi.org/10.1016/b978-0-12-822550-9.00002-8
Autor:
Kevin B. Ita
Vesicles are described and evaluated in this chapter. Liposomes are lipid bilayers rolled up into spherical shells with enclosed liquid within shells, separated from the outer (surrounding) liquid solution. On the other hand, elastic liposomes (ELs;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cab37ba8a31228addf3f242f2a8fd761
https://doi.org/10.1016/b978-0-12-822550-9.00004-1
https://doi.org/10.1016/b978-0-12-822550-9.00004-1