Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kevin B Clairmont"'
Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands
Autor:
Jeffrey T. Bagdanoff, Thomas M. Smith, Martin Allan, Peter O’Donnell, Zachary Nguyen, Elizabeth A. Moore, Jason Baird, Shuangxi Wang, Vanitha Subramanian, Bruno Tigani, David O. Nettleton, Lauren G. Monovich, Ian Lewis, Alec N. Flyer, Brian Granda, John W. Blankenship, David Barnes-Seeman, Kevin B. Clairmont
Publikováno v:
Cell Chemical Biology. 30:97-109.e9
Autor:
Margaret E Brousseau, Kevin B Clairmont, Glen Spraggon, Alec N Flyer, Andrei A Golosov, Philipp Grosche, Jérôme André, Shari Caplan, Guanjing Chen, Li Fan, Raphael Gattlen, Alexander Koch, Ian Lewis, Jingzhou Li, Eugene Liu, Danuta Lubicka, Andreas Marzinzik, Katsumasa Nakajima, David Nettleton, Johannes Ottl, Meihui Pan, Tajesh Patel, Stephanie Pickett, Jennifer Poirier, Patrick C Reid, Xavier Pelle, Vanitha Subramanian, Victoria Vera, Mei Xu, Lihua Yang, Qing Yang, jinghua yu, Guoming Zhu, Lauren G Monovich
Publikováno v:
Circulation. 144
Elevated LDL-C is a major risk factor for atherosclerotic cardiovascular disease, the leading cause of death worldwide. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has pronounced effects on LDL-C levels via its modulation of hepatic LDL rec
Autor:
Katsumasa Nakajima, David Nettleton, Guoming Zhu, Debra Burdick, Alexander W. Koch, Qing Yang, Glen Spraggon, Margaret E. Brousseau, Guanjing Chen, Lisa Ames, Raphael Gattlen, Flyer Alec, Jennifer Poirier, Jingzhou Li, Mohindra Seepersaud, Dawn Kelly-Sullivan, Stephanie Pickett, Xavier Pelle, Lauren Perry, Raj Chopra, Jakal Amin, Jerome Andre, Danuta Lubicka, Victoria Vera, Philipp Grosche, Patel Tajesh Jayprakash, Ian Lewis, Lihua Yang, Eugene Liu, Andrei Golosov, jinghua yu, Li Fan, Patrick C. Reid, Lauren G. Monovich, Shari L. Caplan, Meihui Pan, Diana Dubiel, Vanitha Subramanian, Kevin B. Clairmont, Johannes Ottl, Mei Xu, Andreas Marzinzik
Publikováno v:
Cell Chemical Biology. 29:249-258.e5
Summary Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-
Autor:
Michael H. Serrano-Wu, Alan D. Neubert, Katsumasa Nakajima, Jingzhou Li, Qing Yang, David Truong, Kevin B. Clairmont, Renee Commerford, Aaron Kanter, Thomas Daniels, Young-Shin Kwak, Paul V. Szklennik, Yongjin Gong, Vivienne Tedesco, Gary M. Coppola, Brian K. Hubbard, Ricardo E. Chatelain, Thomas A. Gilmore, Charles D. Meyers, Forster Cornelia J, Monish Jain, James Thompson
Publikováno v:
Journal of medicinal chemistry. 60(11)
Modification of a gut restricted class of benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability. The key structural changes to 1 include bioisosteric replacement of the amide with oxadiazole and α,α-dimethylation of the carboxylic
Autor:
Taeyoung Yoon, Kevin B. Clairmont, Yongjin Gong, Qing Yang, Marlene Juedes, Andrew Tyler, Michael H. Serrano-Wu, Theresa Cosker, Moo Je Sung, Tara L. Mullarkey, Lisha Li, Gary M. Coppola, Alan D. Neubert, Thomas Daniels, Erik C. Rocheford, Renee Commerford, Ying Hou, Ricardo E. Chatelain, Monish Jain, Brian K. Hubbard
Publikováno v:
ACS Medicinal Chemistry Letters. 3:411-415
High DGAT1 expression levels in the small intestine highlight the critical role this enzyme plays in nutrient absorption. Identification of inhibitors which predominantly inhibit DGAT1 in the gut is an attractive drug discovery strategy with anticipa
Autor:
William P. Dole, Mary D. L. Chau, Sandra C. Souza, Marie-Soleil Gauthier, Kevin B. Clairmont, Qing Yang, Jesper Gromada, Zhidan Wu
Publikováno v:
Biochemical and Biophysical Research Communications. 410:398-403
Highlights: {yields} Treatment of differentiated human adipocytes with atrial natriuretic peptide (ANP) increased lipolysis and oxygen consumption by activating AMP-activated protein kinase (AMPK). {yields} ANP stimulated lipid mobilization by select
Autor:
Andrea Bell, Stephanie L. Yung, Ling Yang, Joanne M. Buxton, Clark Q. Pan, Thomas H. Claus, Hongxing Chen, James Whelan, Kevin B. Clairmont, Margit MacDougall, Irene Tom
Publikováno v:
Journal of Biological Chemistry. 281:12506-12515
The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, whereas glucagon stimulates gluconeogenesis and glycogenolysis in the l
Specific Inhibition of Hormone-Sensitive Lipase Improves Lipid Profile while Reducing Plasma Glucose
Autor:
Yin Liang, Christine Keiper Lubeski, Lynn Lemoine, Jian Zhu, Kevin B. Clairmont, Thomas H. Claus, Ling Yang, Arthur I. Salhanick, Derek B. Lowe
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:1396-1402
Elevation of plasma free fatty acids has been linked with insulin resistance and diabetes. Inhibition of lipolysis may provide a mechanism to decrease plasma fatty acids, thereby improving insulin sensitivity. Hormone-sensitive lipase (HSL) is a crit
Publikováno v:
Journal of Biological Chemistry. 277:17677-17686
The insulin-regulated aminopeptidase (IRAP) is a zinc-dependent membrane aminopeptidase. It is the homologue of the human placental leucine aminopeptidase. In fat and muscle cells, IRAP colocalizes with the insulin-responsive glucose transporter GLUT
Autor:
Michael P. Czech, Kevin B. Clairmont
Publikováno v:
Journal of Biological Chemistry. 266:12131-12134
The presence of a soluble, truncated form of the IGF-II/Man-6-P receptor in serum has suggested that cleavage from the cell surface may be an initial step in the degradation of this protein (MacDonald, R. G., Tepper, M. A., Clairmont, K. B., Perregau