TGFβ‐induced FOXS1 controls epithelial–mesenchymal transition and predicts a poor prognosis in liver cancer

Autor: Kevin Bévant, Matthis Desoteux, Gaëlle Angenard, Raphaël Pineau, Stefano Caruso, Corentin Louis, Panagiotis Papoutsoglou, Laurent Sulpice, David Gilot, Jessica Zucman‐Rossi, Cédric Coulouarn

Publikováno v: Hepatology Communications, Vol 6, Iss 5, Pp 1157-1171 (2022)

Transforming growth factor beta (TGF‐β) plays a key role in tumor progression, notably as a potent inducer of epithelial–mesenchymal transition (EMT). However, all of the molecular effectors driving TGFβ‐induced EMT are not fully characterize

Externí odkaz: https://doaj.org/article/88f8ea927575427898d86aa5d00ead50

DNA Methylation of TGFβ Target Genes: Epigenetic Control of TGFβ Functional Duality in Liver Cancer

Autor: Kevin Bévant, Matthis Desoteux, Abdel Hady A. Abdel Wahab, Sabrin A. Abdel Wahab, Ayman Mohamed Metwally, Cédric Coulouarn

Publikováno v: Cells, Vol 10, Iss 9, p 2207 (2021)

Transforming growth factor beta (TGFβ) plays a key role in liver carcinogenesis. However, its action is complex, since TGFβ exhibits tumor-suppressive or oncogenic properties, depending on the tumor stage. At an early stage TGFβ exhibits cytostati

Externí odkaz: https://doaj.org/article/700843e894e74c84a20b29905781bbda

A Minimal Subset of Seven Genes Associated with Tumor Hepatocyte Differentiation Predicts a Poor Prognosis in Human Hepatocellular Carcinoma

Autor: Corentin Louis, Kevin Bévant, Cédric Coulouarn, Matthis Desoteux, Denise Glaise

Publikováno v: Cancers, Vol 13, Iss 5624, p 5624 (2021)
Cancers
Cancers, 2021, 13 (22), pp.5624. ⟨10.3390/cancers13225624⟩
Volume 13
Issue 22
Cancers, MDPI, 2021, 13 (22), pp.5624. ⟨10.3390/cancers13225624⟩

Simple Summary Liver cancer is one of the most commonly diagnosed cancers worldwide and the fourth leading cause of cancer-related deaths. Hepatocellular carcinoma (HCC) accounts for at least 80% of all malignant liver primary tumors. A better charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a783aff461c3487dc7b1957cbe7721c5
https://www.mdpi.com/2072-6694/13/22/5624

Landscape of genomic alterations in hepatocellular carcinoma: current knowledge and perspectives for targeted therapies

Autor: Cédric Coulouarn, Kevin Bévant

Publikováno v: Hepatobiliary Surgery and Nutrition
Hepatobiliary Surgery and Nutrition, AME Publishing Company, 2017, 6 (6), pp.404-407. ⟨10.21037/hbsn.2017.10.02⟩
Hepatobiliary Surgery and Nutrition, 2017, 6 (6), pp.404-407. ⟨10.21037/hbsn.2017.10.02⟩

Hepatocellular carcinoma (HCC) is a deadly cancer worldwide characterized by a rising incidence and limited therapeutic options (1). HCC is associated with multiple risk factors, including chronic hepatitis B and C (HBV/HCV), alcohol intake, aflatoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f60629ed863ffd92f7e9f5ec459a7c3
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01697001