Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kevin Alan Myers"'
Autor:
Mark R. Middleton, Anthony Cutts, Alan Sharpe, L Collins, Roz Brant, Darren Hodgson, Frances Willenbrock, Kevin Alan Myers, Ruth Asher, Adelyn Wise, Sharon Love, Anna Schuh, Avinash Gupta, Valentine M. Macaulay, Christopher Towers, Paul D. Smith
Publikováno v:
British Journal of Cancer
Background Aiming to improve treatment options for BRAF wild-type melanoma, we previously conducted the DOC-MEK study of docetaxel with MEK inhibitor (MEKi) selumetinib or placebo, revealing trends to prolongation of progression-free survival (hazard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c6be781ebf024794abbf090e413a57
https://doi.org/10.1038/s41416-019-0673-5
https://doi.org/10.1038/s41416-019-0673-5
Autor:
N. Drury, Kevin Alan Myers, Miles W. Carroll, Juan W. Valle, Noel B Connolly, Richard Harrop, Matthew G. Ryan, Susan M. Kingsman, Robert E. Hawkins, Mark P Saunders, Irina Redchenko
Publikováno v:
Clinical Cancer Research. 12:3416-3424
Purpose: The highly attenuated strain of vaccinia virus, modified vaccinia Ankara (MVA), encoding the tumor antigen 5T4 (termed TroVax), has been evaluated in an open-label phase I/II study in colorectal cancer patients. The primary objectives were t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89132b2eecef200864d7330f254f9c6
https://doi.org/10.1158/1078-0432.ccr-05-2732
https://doi.org/10.1158/1078-0432.ccr-05-2732
Autor:
Alberto Caggiati, Hugo Partsch, A. Cavezzi, Nicos Labropoulos, Kevin Alan Myers, P. C. Coleridge Smith, Andrew Nicolaides, Serafino Ricci
Publikováno v:
Phlebologie. 35:256-263
Hintergrund: Die Duplex-Ultraschalluntersuchung ist der Goldstandard zur Beurteilung von Morphologie und Hamodynamik der Venen der unteren Extremitaten. Das in der vorliegenden Arbeit beschriebene Projekt wurde auf Grund einer Initiative der UIP (Uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa024154a8e6a39c5a229ae95c48ed6f
https://doi.org/10.1055/s-0037-1622151
https://doi.org/10.1055/s-0037-1622151
Autor:
Susan M. Kingsman, Peter L. Stern, Miles W. Carroll, M Jim Embleton, Matthew G. Ryan, Kevin Alan Myers, David M Shaw
Publikováno v:
Cancer Gene Therapy. 9:884-896
Although several clinical trials have shown beneficial effects by targeting tumor-associated antigens (TAAs) with monoclonal antibodies, a number of issues, including poor penetration of the tumor mass and human antimouse antibody responses, remain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01fb5ce24f57378623118343df0de88
https://doi.org/10.1038/sj.cgt.7700513
https://doi.org/10.1038/sj.cgt.7700513
Autor:
Caroline Westwater, Susan M. Kingsman, Peter L. Stern, M.J. Embleton, Miles W. Carroll, Kevin Alan Myers, Matthew G. Ryan, David M Shaw
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1524:238-246
The oncofoetal antigen 5T4 is a 72 kDa glycoprotein expressed at the cell surface. It is defined by a monoclonal antibody, mAb5T4, that recognises a conformational extracellular epitope in the molecule. Overexpression of 5T4 antigen by tumours of sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3185e6f02107eaf9c432be291bc30da1
https://doi.org/10.1016/s0304-4165(00)00165-3
https://doi.org/10.1016/s0304-4165(00)00165-3
Publikováno v:
International Journal of Cancer. 68:84-92
The 5T4 antigen is defined by a monoclonal antibody (MAb) specific for human trophoblast. It is also expressed by many types of tumour cell and has been associated with metastasis and poor clinical outcome in a number of cancers. This pattern of expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed317d772d75e1215b687e8ca824a62
https://doi.org/10.1002/(sici)1097-0215(19960927)68:1<84::aid-ijc15>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19960927)68:1<84::aid-ijc15>3.0.co
Publikováno v:
Journal of Cell Science. 108:2905-2916
The 5T4 oncofoetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd53aa8a1489a147231c40391a5e4a7
https://doi.org/10.1242/jcs.108.8.2905
https://doi.org/10.1242/jcs.108.8.2905
Autor:
Philip F Schofield, Kevin Alan Myers, P J Marsh, Stephen A Roberts, Teresa Starzyńska, Peter L. Stern
Publikováno v:
British Journal of Cancer
The 5T4 oncofetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4c7a4c8a89f43721263f256c8cba50
https://doi.org/10.1038/bjc.1994.173
https://doi.org/10.1038/bjc.1994.173
Autor:
M D Davison, Amanada J Cheater, Kevin Alan Myers, Peter L. Stern, J A Young, Veena Rahi-Saund
Publikováno v:
Journal of Biological Chemistry. 269:9319-9324
The monoclonal antibody 5T4 defines a human oncotrophoblast antigen expressed by a variety of carcinomas but with a restricted pattern of expression in normal adult tissues. The 5T4 antigen has been isolated from term placenta as a 72-kDa glycoprotei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::135f0d61961226c0b8f67f4868ff2e0d
https://doi.org/10.1016/s0021-9258(17)37110-7
https://doi.org/10.1016/s0021-9258(17)37110-7
Autor:
Miles W. Carroll, Kevin Alan Myers, Irina Redchenko, Susan M. Kingsman, Richard Harrop, Matthew G. Ryan
Publikováno v:
Cancer immunology, immunotherapy : CII. 55(9)
5T4 is a tumor associated antigen that is expressed on the surface of a wide spectrum of human adenocarcinomas. The highly attenuated virus, modified vaccinia Ankara, has been engineered to express human 5T4 (h5T4). In a pre-clinical murine model, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0f1bdf76976d7d67b4782a7835fc6a
https://pubmed.ncbi.nlm.nih.gov/16311730
https://pubmed.ncbi.nlm.nih.gov/16311730