Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Kevin A.W. Lee"'
Publikováno v:
Protein Science. 27:633-642
The FET sub-family (FUS/TLS, EWS, TAF15) of RNA-binding proteins have remarkably similar overall structure but diverse biological and pathological roles. The molecular basis for FET protein specialization is largely unknown. Gly-Arg-Rich regions (RGG
Publikováno v:
Transcription. 7:141-151
The multi-functional TET (TAF15/EWS/TLS) or FET (FUS/EWS/TLS) protein family of higher organisms harbor a transcriptional-activation domain (EAD) and an RNA-binding domain (RBD). The transcriptional activation function is, however, only revealed in o
Autor:
Luciana Madeira da Silva, Tyler E. Mattox, Adam B. Keeton, Gary A. Piazza, Harry S. Cooper, Margie L. Clapper, Kristy L. Berry, Yulia Maxuitenko, Kevin A.W. Lee, Wen-Chi L. Chang, Bing Zhu, Michael R. Boyd, Xi Chen, Jacob Valiyaveettil, Veronica Ramirez-Alcantara, Antonio Ward
Publikováno v:
Cancer Research. 79:3864-3864
Over 90% of colorectal cancers harbor mutations in β-catenin or pathway components (e.g. APC) that stabilize β-catenin, causing nuclear translocation and constitutive Tcf-mediated transcription of genes encoding proteins essential for the prolifera
Publikováno v:
Biochemistry. 48:2849-2857
Aberrant chromosomal fusion of the Ewings sarcoma oncogene (EWS) to several different cellular partners gives rise to the Ewing's family of oncogenic proteins [EWS fusion proteins (EFPs)] and associated tumors (EFTs). EFPs are potent transcriptional
Autor:
Christopher T. Denny, Vladimir N. Uversky, Gary Potikyan, Rupert O. V. Savene, King Pan Ng, Kevin A.W. Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 104:479-484
Chromosomal translocations involving the N-terminal ≈250 residues of the Ewings sarcoma (EWS) oncogene produce a group of EWS fusion proteins (EFPs) that cause several distinct human cancers. EFPs are potent transcriptional activators and interact
Autor:
Deepa Alex, Kevin A.W. Lee
Publikováno v:
Nucleic Acids Research
The Ewings Sarcoma Oncoprotein (EWS) interacts with several components of the mammalian transcriptional and pre-mRNA splicing machinery and is also found in the cytoplasm and even on the cell surface. The apparently diverse cellular functions of EWS
Autor:
Takayuki Nojima, Colin R. Goding, Hiroaki Hiraga, Kim K.C. Li, Kevin A.W. Lee, Kazuo Nagashima, Jane C. Goodall, SK Liao, Karl-Ludwig Schaefer, Chun Hua Wang, YC Lin
Publikováno v:
British Journal of Cancer
Clear cell sarcoma (CCS) is associated with the EWS/ATF1 oncogene that is created by chromosomal fusion of the Ewings Sarcoma oncogene (EWS) and the cellular transcription factor ATF1. The melanocytic character of CCS suggests that the microphthalmia
Autor:
Gavin Bennett, Diane Blakeley, Katerine Van Rietschoten, Robert J. Lutz, Helen Harrison, Silvia Pavan, Spencer Campbell, Liuhong Chen, Daniel Teufel, Peter U. Park, Amy E. Caruso Brown, Kevin A.W. Lee
Publikováno v:
Cancer Research. 77:5144-5144
Bicycles® are novel binding agents comprising small bicyclic peptides (1.5-3 KDa) constrained via a chemical scaffold, selected for high affinity and selectivity to targets of interest. MT1 (MMP14/MT1-MMP) is a membrane-associated metalloprotease ov
Publikováno v:
Cancer Research. 77:1167-1167
BT1718 is a Bicycle Drug Conjugate (BDC®) comprising a constrained bicyclic peptide (Bicycle®) that binds with high affinity and specificity to membrane type 1-matrix metalloprotease (MT1-MMP; MMP14) covalently linked through a hindered disulfide l
Autor:
Liang Feng, Kevin A.W. Lee
Publikováno v:
Oncogene. 20:4161-4168
Chromosomal fusion of the N-terminal region of the Ewings Sarcoma Oncogene (EWS-activation-domain, EAD) to the DNA-binding domains of a variety of cellular transcription factors produce oncogenic proteins (EWS-fusion proteins (EFPs)) that cause disti