Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kevin A. Welle"'
Autor:
Min-Han Lin, Madeline K. Jensen, Nathan D. Elrod, Kai-Lieh Huang, Kevin A. Welle, Eric J. Wagner, Liang Tong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Integrator is a multi-subunit protein complex with roles in noncoding RNA 3′-end processing and mRNA transcription attenuation. Here, the authors reveal a conserved binding site for IP6 in the Integrator cleavage module and show that IP6 binding is
Externí odkaz:
https://doaj.org/article/0ee6e6961b0d4fdaad96646285719378
Autor:
Aurel Popa-Wagner, Raluca E. Sandu, Coman Cristin, Adriana Uzoni, Kevin A. Welle, Jennifer R. Hryhorenko, Sina Ghaemmaghami
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Brain structures differ in the magnitude of age-related neuron loss with the cerebellum being more affected. An underlying cause could be an age-related decline in mitochondrial bioenergetics. Successful aging of mitochondria reflects a balanced turn
Externí odkaz:
https://doaj.org/article/48f075825d854e519fd6c901cc4cf465
Autor:
John Q. Bettinger, Matthew Simon, Anatoly Korotkov, Kevin A. Welle, Jennifer R. Hryhorenko, Andrei Seluanov, Vera Gorbunova, Sina Ghaemmaghami
Publikováno v:
Journal of Proteome Research. 21:1495-1509
The oxidation of methionine has emerged as an important post-translational modification of proteins. A number of studies have suggested that the oxidation of methionines in select proteins can have diverse impacts on cell physiology, ranging from det
Autor:
Ruiyue Tan, Margaret Hoare, Kevin A. Welle, Kyle Swovick, Jennifer R. Hryhorenko, Sina Ghaemmaghami
The folding of most proteins occurs during the course of their translation while their tRNA-bound C-termini are embedded in the ribosome. How the close proximity of nascent proteins to the ribosome influences their folding thermodynamics remains poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c247365ec8aea256c556c195cf6f67a
https://doi.org/10.1101/2022.11.07.515500
https://doi.org/10.1101/2022.11.07.515500
Autor:
Michele Crotti, Simone Giovani, Hanan Alwaseem, Rudi Fasan, Sina Ghaemmaghami, Craig T. Jordan, Kevin A. Welle
Publikováno v:
ACS Central Science, Vol 7, Iss 5, Pp 841-857 (2021)
ACS Central Science
ACS Central Science
The plant-derived sesquiterpene lactone micheliolide was recently found to possess promising antileukemic activity, including the ability to target and kill leukemia stem cells. Efforts toward improving the biological activity of micheliolide and inv
Autor:
Marissa Sobolewski, Matthew L Eckard, Elena Marvin, Deborah A. Cory-Slechta, Alyssa K. Merrill, Katherine Conrad, Günter Oberdörster, Kevin A. Welle, Tim J. Anderson
Publikováno v:
Toxicol Sci
Epidemiological and experimental studies have associated oral and systemic exposures to the herbicide paraquat (PQ) with Parkinson’s disease. Despite recognition that airborne particles and solutes can be directly translocated to the brain via olfa
Autor:
John Q. Bettinger, Matthew Simon, Anatoly Korotkov, Kevin A. Welle, Jennifer R. Hryhorenko, Andrei Seluanov, Vera Gorbunova, Sina Ghaemmaghami
The oxidation of methionine side chains has emerged as an important posttranslational modification of proteins. A diverse array of low-throughput and targeted studies have suggested that the oxidation of methionine residues in select proteins can hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a7ad76ef46b83c2e1dbccb6a7cebbd
https://doi.org/10.1101/2022.02.19.481142
https://doi.org/10.1101/2022.02.19.481142
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Prion diseases are rare, neurological disorders caused by the misfolding of the cellular prion protein (PrPC) into cytotoxic fibrils (PrPSc). Intracellular PrPSc aggregates primarily accumulate within late endosomes and lysosomes, organelles that par
Autor:
Ethan J. Walker, John Q. Bettinger, Kevin A. Welle, Jennifer R. Hryhorenko, Adrian M. Molina Vargas, Mitchell R. O’Connell, Sina Ghaemmaghami
The oxidation of protein-bound methionines to form methionine sulfoxides has a broad range of biological ramifications, making it important to delineate factors that influence methionine oxidation rates within a protein. This is especially important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214cd72785670c25091ab890c38a108b
https://doi.org/10.1101/2021.12.20.473526
https://doi.org/10.1101/2021.12.20.473526
Autor:
Abdellatif Benraiss, John N. Mariani, Ashley Tate, Pernille M. Madsen, Kathleen M. Clark, Kevin A. Welle, Renee Solly, Laetitia Capellano, Karen Bentley, Devin Chandler-Militello, Steven A. Goldman
Publikováno v:
Benraiss, A, Mariani, J N, Tate, A, Madsen, P M, Clark, K M, Welle, K A, Solly, R, Capellano, L, Bentley, K, Chandler-Militello, D & Goldman, S A 2022, ' A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice ', Cell Reports, vol. 40, no. 9, 111291 . https://doi.org/10.1016/j.celrep.2022.111291
Huntington’s disease (HD) is characterized by defective oligodendroglial differentiation and white matter disease. Here, we investigate the role of oligodendrocyte progenitor cell (OPC) dysfunction in adult myelin maintenance in HD. We first note a