Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kevin A. Strait"'
Publikováno v:
American Journal of Physiology-Renal Physiology. 302:F1325-F1330
Collecting duct (CD) endothelin-1 (ET-1) is an important autocrine inhibitor of Na and water transport. CD ET-1 production is stimulated by extracellular fluid volume expansion and tubule fluid flow, suggesting a mechanism coupling CD Na delivery and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb24f2e5b30593b9aebb36fa39ee5e68
https://doi.org/10.1152/ajprenal.00034.2012
https://doi.org/10.1152/ajprenal.00034.2012
Publikováno v:
American Journal of Physiology-Renal Physiology. 302:F78-F84
Collecting duct (CD) adenylyl cyclase VI (AC6) has been implicated in arginine vasopressin (AVP)-stimulated renal water reabsorption. To evaluate the role of CD-derived AC6 in regulating water homeostasis, mice were generated with CD-specific knockou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f489d218bae3aa817b1aff2dbeb187
https://doi.org/10.1152/ajprenal.00397.2011
https://doi.org/10.1152/ajprenal.00397.2011
Publikováno v:
Cell Biochemistry and Biophysics. 61:643-650
Endothelin-1 (ET-1) is produced in unusually large amounts by the renal collecting duct and acts locally to control renal salt and water excretion and arterial pressure; disorders of collecting duct ET-1 activity can cause marked hypertension. The me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474340d4384b8f3715ebc9010b8f0ab8
https://doi.org/10.1007/s12013-011-9250-0
https://doi.org/10.1007/s12013-011-9250-0
Publikováno v:
Journal of Biological Chemistry. 285:28520-28528
Collecting duct-derived ET-1 regulates salt excretion and blood pressure. We have reported the presence of an inner medullary collecting duct (IMCD)-specific enhancer region in the 5′-upstream ET-1 promoter (Strait, K. A., Stricklett, P. K., Kohan,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369ad6325337e6195439e682008a70c4
https://doi.org/10.1074/jbc.m110.153189
https://doi.org/10.1074/jbc.m110.153189
Publikováno v:
American Journal of Physiology-Renal Physiology. 298:F859-F867
Little is known about collecting duct adenylyl cyclase (AC) isoforms or regulation in the mouse. We performed RT-PCR for AC isoforms 1–9 in microdissected cortical (CCD) and outer medullary (OMCD) and acutely isolated inner medullary (IMCD) collect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e848a325a038cc34dcc4070c61376be
https://doi.org/10.1152/ajprenal.00109.2009
https://doi.org/10.1152/ajprenal.00109.2009
Autor:
Kalani L. Raphael, Donald E. Kohan, Klaus Piontek, Bradley C. Baird, Peter K. Stricklett, Kevin A. Strait, Gregory G. Germino
Publikováno v:
American Journal of Nephrology. 30:468-473
Background/Aims: Cystic epithelia in polycystic kidney disease display features similar to malignant cells. Thiazolidinediones have been shown to have anti-neoplastic properties, therefore we tested the hypothesis that pioglitazone reduces cyst forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe1bb1687c16fd577d70c29e8a6b7c4
https://doi.org/10.1159/000242432
https://doi.org/10.1159/000242432
Publikováno v:
American Journal of Physiology-Renal Physiology. 293:F601-F606
Collecting duct-derived endothelin-1 (ET-1) reduces blood pressure and inhibits Na and water reabsorption. Collecting duct ET-1 production is increased by volume expansion; however, the mechanism by which this occurs is unknown. We hypothesized that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07906cf8c54416dc05a0c3ce7ea8f612
https://doi.org/10.1152/ajprenal.00085.2007
https://doi.org/10.1152/ajprenal.00085.2007
Autor:
Kevin A. Strait, Donald E. Kohan, Wararat Kittikulsuth, Alfred N. Van Hoek, Sara Rees, Karl P. Roos
cAMP is an important mediator of cystogenesis in polycystic kidney disease (PKD). Several adenylyl cyclase (AC) isoforms could mediate cAMP accumulation in PKD, and identification of a specific pathogenic AC isoform is of therapeutic interest. We inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7af470c1d20962410706b2f2ce1d5e
https://europepmc.org/articles/PMC3904559/
https://europepmc.org/articles/PMC3904559/
Autor:
Donald E. Kohan, Robert Koesters, Sara Rees, Stephanie K Woodward, Kevin A. Strait, Deborah Stuart
Publikováno v:
BMC Nephrology
BMC Nephrology, 2012, 13 (1), pp.166. ⟨10.1186/1471-2369-13-166⟩
BMC Nephrology, BioMed Central, 2012, 13 (1), pp.166. ⟨10.1186/1471-2369-13-166⟩
BMC Nephrology, Vol 13, Iss 1, p 166 (2012)
BMC Nephrology, 2012, 13 (1), pp.166. ⟨10.1186/1471-2369-13-166⟩
BMC Nephrology, BioMed Central, 2012, 13 (1), pp.166. ⟨10.1186/1471-2369-13-166⟩
BMC Nephrology, Vol 13, Iss 1, p 166 (2012)
Background Endothelin, via endothelin A receptors (ETA), exerts multiple pathologic effects that contribute to disease pathogenesis throughout the body. ETA antagonists ameliorate many experimental diseases and have been extensively utilized in clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f2020e49a78ed44c84e2ab6675e870
https://www.hal.inserm.fr/inserm-00770271
https://www.hal.inserm.fr/inserm-00770271