Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Kevin A. Coleman"'
Autor:
Asli Muvaffak, Kevin G. Coleman
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundAtaxia telangiectasia-mutated (ATM) kinase is a central regulator of the DNA damage response (DDR) signaling pathway, and its function is critical for the maintenance of genomic stability in cells that coordinate a network of cellular proce
Externí odkaz:
https://doaj.org/article/25bed31213ed4a50acfbdf2081992ecd
Autor:
Karen A. Simon-Crevatis, Shailesh R. Metkar, Justin T. Hardcastle, Keith Jansson, Usman Shabon, Rajarshi Choudhury, Euan A. Stronach, Kevin G. Coleman, Asli Muvaffak
Publikováno v:
Cancer Research. 83:6175-6175
While cyclin dependent kinases (CDKs) were originally implicated in cell cycle regulation, several CDKs including CDK7, CDK8, and CDK9 play critical roles in transcription through regulation of RNA polymerase II (Pol II) activity. In addition to expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e5a84d1ec42e305a931c904608fbcac
https://doi.org/10.1158/1538-7445.am2023-6175
https://doi.org/10.1158/1538-7445.am2023-6175
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28022 (2011)
Although G-protein coupled receptors (GPCRs) are a common element in many chemosensory transduction pathways in eukaryotic cells, no GPCR or regulated G-protein activity has yet been shown in any ciliate. To study the possible role for a GPCR in the
Externí odkaz:
https://doaj.org/article/95d378cfa44f4b8786aa80071bbb1727
Autor:
Nathaniel L. Elsen, Zangwei Xu, Peter J. Dandliker, Peter Saradjian, Keith W. Rickert, Berengere Sauvagnat, Nadya Smotrov, Dawn L. Hall, Elliott B. Nickbarg, Yiping Chen, Sujata Sharma, Kevin J. Lumb, Maria Kornienko, Noel Byrne, Chad Chamberlin, Christine Andrews, Samantha J Allen, Ilona Kariv, Jennifer M. Shipman, Patrick J. Curran, Kevin G. Coleman, Beutel Bruce A, Rachael E. Ford, Victoria Kutilek, Andrew Hashke, Rafael Fernandez, Tianxiao Sun, Matthew Richards, Ryan Boinay
Publikováno v:
SLAS Discovery. 21:608-619
The primary objective of early drug discovery is to associate druggable target space with a desired phenotype. The inability to efficiently associate these often leads to failure early in the drug discovery process. In this proof-of-concept study, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321009edd98ca17a57d26928e293e5e3
https://doi.org/10.1177/1087057116637353
https://doi.org/10.1177/1087057116637353
Autor:
Asli Muvaffak, Kevin G. Coleman
Publikováno v:
Cancer Research. 80:2379-2379
PARP inhibitors have transformed the treatment for ovarian cancer, which is known to have high incidence of homologous recombination (HR) deficiency through the loss of BRCA1 or BRCA2 genes. 30-35% of ovarian cancer patients have defects in BRCA1/2 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59e05a63b3d18ba5e8e8b14ae86e00d6
https://doi.org/10.1158/1538-7445.am2020-2379
https://doi.org/10.1158/1538-7445.am2020-2379
Autor:
Vanna M Dickerson, Corey F. Saba, Karen K. Cornell, MaryAnn G. Radlinsky, Morika Ogawa, Chad W. Schmiedt, Kevin D. Coleman
Publikováno v:
Journal of the American Veterinary Medical Association. 247:786-792
Objective—To evaluate outcomes of dogs and owner satisfaction and perception of their dogs’ adaptation following amputation of a thoracic or pelvic limb. Design—Retrospective case series. Animals—64 client-owned dogs. Procedures—Medical rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d394abf1ae3665343d5379bbbe09e9af
https://doi.org/10.2460/javma.247.7.786
https://doi.org/10.2460/javma.247.7.786
Publikováno v:
Clinical Practice in Pediatric Psychology. 3:218-224
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfd7619c2c4235b9d5d19bc05d64b575
https://doi.org/10.1037/cpp0000102
https://doi.org/10.1037/cpp0000102
Publikováno v:
Veterinary Surgery. 44:613-626
Objective To provide (1) a comprehensive description of hemipelvectomy; and (2) report clinical application and outcome of hemipelvectomy in dogs and cats. Study Design Descriptive report and retrospective case series. Animals Dogs (n = 4) and 5 cats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e6e9080fd666b1c69062979169bb0f
https://doi.org/10.1111/vsu.12324
https://doi.org/10.1111/vsu.12324
Autor:
Jing Ju Wang, Sarah Wang, Bin Feng, Kevin G. Coleman, Yinghui Zhou, Asli Muvaffak, Sridhar Ramaswamy
Publikováno v:
Molecular Cancer Therapeutics. 18:A091-A091
Non-Small Cell Lung Cancer (NSCLC) is the leading cause of cancer related mortality worldwide, and accounts for 80-85% of all lung cancer diagnoses. While targeted therapies against epidermal growth factor receptor (EGFR) mutations and anaplastic lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c2501ed89d7afdb4091c15b2ce66f35
https://doi.org/10.1158/1535-7163.targ-19-a091
https://doi.org/10.1158/1535-7163.targ-19-a091
Autor:
Johanna K. Kaufmann, Brianna Flynn, Kevin Morse, Maria C. Speranza, Jing Zhou, Sridhar Ramaswamy, Sean Mackay, Kevin G. Coleman
Publikováno v:
Cancer Research. 79:3242-3242
Co-expression of immune checkpoint receptors (ICRs) PD-1, TIM-3, and LAG-3 characterizes chronically activated and exhausted tumor-infiltrating T cells (TILs), suggesting their targeting may have applicability for the treatment of multiple cancer typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d0a3acf5eb57b994769cf3bb47ac07
https://doi.org/10.1158/1538-7445.am2019-3242
https://doi.org/10.1158/1538-7445.am2019-3242