Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Kevin A. Bradley"'
Enzyme-assisted high throughput sequencing of an expanded genetic alphabet at single base resolution
Autor:
Bang Wang, Kevin M. Bradley, Myong-Jung Kim, Roberto Laos, Cen Chen, Dietlind L. Gerloff, Luran Manfio, Zunyi Yang, Steven A. Benner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract With just four building blocks, low sequence information density, few functional groups, poor control over folding, and difficulties in forming compact folds, natural DNA and RNA have been disappointing platforms from which to evolve recepto
Externí odkaz:
https://doaj.org/article/025d698ec3364749b2c91f336ff28175
Autor:
Meghi Dedja, Abolfazl Mehranian, Kevin M. Bradley, Matthew D. Walker, Patrick A. Fielding, Scott D. Wollenweber, Robert Johnsen, Daniel R. McGowan
Publikováno v:
EJNMMI Physics, Vol 11, Iss 1, Pp 1-12 (2024)
Abstract Background Investigate the potential benefits of sequential deployment of two deep learning (DL) algorithms namely DL-Enhancement (DLE) and DL-based time-of-flight (ToF) (DLT). DLE aims to enhance the rapidly reconstructed ordered-subset-exp
Externí odkaz:
https://doaj.org/article/02d146a8ba474501ac1bed66b6abd0d2
Autor:
Nesrine Lajmi, Sofia Alves-Vasconcelos, Apostolos Tsiachristas, Andrew Haworth, Kerrie Woods, Charles Crichton, Theresa Noble, Hizni Salih, Kinga A. Várnai, Harriet Branford-White, Liam Orrell, Andrew Osman, Kevin M. Bradley, Lara Bonney, Daniel R. McGowan, Jim Davies, Matthew S. Prime, Andrew Bassim Hassan
Publikováno v:
Cambridge Prisms: Precision Medicine, Vol 2 (2024)
The personalised oncology paradigm remains challenging to deliver despite technological advances in genomics-based identification of actionable variants combined with the increasing focus of drug development on these specific targets. To ensure we co
Externí odkaz:
https://doaj.org/article/7338436f990d4a39a0a9ec2593a3623f
Autor:
Dongmin Kim, Terry J DeBriere, Bradley H Eastmond, Abdullah A Alomar, Ozlem Yaren, Jacquelyn McCarter, Kevin M Bradley, Steven A Benner, Barry W Alto, Nathan D Burkett-Cadena
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298805 (2024)
Arthropod-borne viruses are major causes of human and animal disease, especially in endemic low- and middle-income countries. Mosquito-borne pathogen surveillance is essential for risk assessment and vector control responses. Sentinel chicken serosur
Externí odkaz:
https://doaj.org/article/499e81f7115847648c6c350df62feaf4
Autor:
Somnath Mukherjee, Christopher N. Hurt, Richard Adams, Andrew Bateman, Kevin M. Bradley, Sarah Bridges, Stephen Falk, Gareth Griffiths, Sarah Gwynne, Christopher M. Jones, Philip J. Markham, Tim Maughan, Lisette S. Nixon, Ganesh Radhakrishna, Rajarshi Roy, Simon Schoenbuchner, Hamid Sheikh, Emiliano Spezi, Maria Hawkins, Thomas D.L. Crosby
Publikováno v:
EClinicalMedicine, Vol 61, Iss , Pp 102059- (2023)
Summary: Background: The utility of early metabolic response assessment to guide selection of the systemic component of definitive chemoradiotherapy (dCRT) for oesophageal cancer is uncertain. Methods: In this multi-centre, randomised, open-label, ph
Externí odkaz:
https://doaj.org/article/138ca15545ee408b9e0a95d7b868e614
Autor:
Kieran G. Foley, Anita Lavery, Eoin Napier, David Campbell, Martin M. Eatock, Richard D. Kennedy, Kevin M. Bradley, Richard C. Turkington
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract 18F-fluorodeoxyglucose PET-CT may guide treatment decisions in patients with oesophageal adenocarcinoma (OAC). This study evaluated the added value of maximum standardised uptake value (SUVmax) to a novel DNA-damage immune response (DDIR) as
Externí odkaz:
https://doaj.org/article/335f4a45c8e3412591391e3d999c13de
Autor:
Thomas R. Barber, Ludovica Griffanti, Kevin M. Bradley, Daniel R. McGowan, Christine Lo, Clare E. Mackay, Michele T. Hu, Johannes C. Klein
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 1, Pp 26-35 (2020)
Abstract Objectives Rapid eye movement sleep behavior disorder (RBD) patients have a high risk of developing a Parkinsonian disorder, offering an opportunity for neuroprotective intervention. Predicting near‐term conversion, however, remains a chal
Externí odkaz:
https://doaj.org/article/e49d2454783f4722939b38ae3e5f78eb
Autor:
Lyudmyla G. Glushakova, Barry W. Alto, Myong-Sang Kim, Daniel Hutter, Andrea Bradley, Kevin M. Bradley, Nathan D. Burkett-Cadena, Steven A. Benner
Publikováno v:
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background The global expansion of dengue (DENV), chikungunya (CHIKV), and Zika viruses (ZIKV) is having a serious impact on public health. Because these arboviruses are transmitted by the same mosquito species and co-circulate in the same a
Externí odkaz:
https://doaj.org/article/c8e8313e28234e469b3b74c59d5fbe82
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background We aimed to evaluate the clinical robustness of a commercially developed data-driven respiratory gating algorithm based on principal component analysis, for use in routine PET imaging. Methods One hundred fifty-seven adult FDG PET
Externí odkaz:
https://doaj.org/article/7041e12f85f940cbb3a7149229ba8042
Autor:
Ozlem Yaren, Jacquelyn McCarter, Nikhil Phadke, Kevin M Bradley, Benjamin Overton, Zunyi Yang, Shatakshi Ranade, Kunal Patil, Rishikesh Bangale, Steven A Benner
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0240524 (2021)
Managing the pandemic caused by SARS-CoV-2 requires new capabilities in testing, including the possibility of identifying, in minutes, infected individuals as they enter spaces where they must congregate in a functioning society, including workspaces
Externí odkaz:
https://doaj.org/article/1e0bb323e33e4cc3b6e053c05d760cf9