Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Kevin A Murray"'
Autor:
Smriti Sangwan, Shruti Sahay, Kevin A Murray, Sophie Morgan, Elizabeth L Guenther, Lin Jiang, Christopher K Williams, Harry V Vinters, Michel Goedert, David S Eisenberg
Publikováno v:
eLife, Vol 9 (2020)
Seeding, in the context of amyloid disease, is the sequential transfer of pathogenic protein aggregates from cell-to-cell within affected tissues. The structure of pathogenic seeds provides the molecular basis and enables rapid conversion of soluble
Externí odkaz:
https://doaj.org/article/28a8e57e2eee4c3c8246bb0a5890354f
Autor:
Sarah L Griner, Paul Seidler, Jeannette Bowler, Kevin A Murray, Tianxiao Peter Yang, Shruti Sahay, Michael R Sawaya, Duilio Cascio, Jose A Rodriguez, Stephan Philipp, Justyna Sosna, Charles G Glabe, Tamir Gonen, David S Eisenberg
Publikováno v:
eLife, Vol 8 (2019)
Alzheimer’s disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles wh
Externí odkaz:
https://doaj.org/article/b2be6583aeff446ab32b99c277fc5857
Autor:
Ayesha Iqbal, Madiha Ahmad, Kevin J. Murray, Jison Sim, Terry J. S. Lund, Anthony J. Andrade, Ariadna Perez-Sanchez, Michael J. Mader, Elizabeth K. Haro, Jason P. Williams, Robert Nathanson, Nilam J. Soni
Publikováno v:
Rheumatology and Therapy, Vol 11, Iss 3, Pp 855-867 (2024)
Abstract Introduction Point-of-care ultrasound (POCUS) can assist rheumatologists in monitoring disease activity, establishing diagnoses, and guiding procedural interventions. POCUS use has been increasing, but little is known about current use and b
Externí odkaz:
https://doaj.org/article/a1e9c2712fbe4248ac8bd63042f30619
Autor:
Kevin R. Murray, MSc, Jessica A. Poirier, MSc, Jason S. Au, PhD, Eric T. Hedge, MSc, Andrew D. Robertson, PhD, George A. Heckman, MD, Richard L. Hughson, PhD
Publikováno v:
CJC Open, Vol 5, Iss 12, Pp 870-880 (2023)
Background: Insufficient cardiac output in individuals with heart failure (HF) limits daily functioning and reduces quality of life. Although lower cerebral perfusion, secondary to limitations in cardiac output, has been observed during moderate-inte
Externí odkaz:
https://doaj.org/article/8e19e6273d004873bc110be5f4577318
Autor:
Maya Gogtay, Ryan S. Choudhury, Jason P. Williams, Michael J. Mader, Kevin J. Murray, Elizabeth K. Haro, Brandy Drum, Edward O’Brien, Rahul Khosla, Jeremy S. Boyd, Brain Bales, Erin Wetherbee, Harald Sauthoff, Christopher K. Schott, Zahir Basrai, Dana Resop, Brian P. Lucas, Sandra Sanchez-Reilly, Sara Espinosa, Nilam J. Soni, Robert Nathanson
Publikováno v:
BMC Geriatrics, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background Point-of-care ultrasound (POCUS) can aid geriatricians in caring for complex, older patients. Currently, there is limited literature on POCUS use by geriatricians. We conducted a national survey to assess current POCUS use, traini
Externí odkaz:
https://doaj.org/article/dabdb782797248b094561f411baaea92
Autor:
Einav Tayeb-Fligelman, Jeannette T. Bowler, Christen E. Tai, Michael R. Sawaya, Yi Xiao Jiang, Gustavo Garcia, Sarah L. Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M. Seidler, Jiahui Lu, Gregory M. Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R. Boyer, Yan Li, Daniel H. Anderson, Kevin A. Murray, Genesis Falcon, Duilio Cascio, Lorena Saelices, Robert Damoiseaux, Vaithilingaraja Arumugaswami, Feng Guo, David S. Eisenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The self-assembly of the Nucleocapsid protein (NCAP) of SARS-CoV-2 is crucial for its function. Computational analysis of the amino acid sequence of NCAP reveals low-complexity domains (LCDs) akin to LCDs in other proteins known to self-asse
Externí odkaz:
https://doaj.org/article/afcfb5ca25ff4981a1a88a2f530c23e4
Autor:
Paul M. Seidler, Kevin A. Murray, David R. Boyer, Peng Ge, Michael R. Sawaya, Carolyn J. Hu, Xinyi Cheng, Romany Abskharon, Hope Pan, Michael A. DeTure, Christopher K. Williams, Dennis W. Dickson, Harry V. Vinters, David S. Eisenberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Evidence suggests that fibrous aggregates of protein tau may be the proximal cause of Alzheimer’s disease. Here, using atomic structures of tau fibrils from brains of people with Alzheimer’s disease, the authors have found small-molecule drug lea
Externí odkaz:
https://doaj.org/article/a6336cf0b0264ed0a047acb9ca2994cf
Autor:
Kevin O. Murray, Sophia A. Mahoney, Ravinandan Venkatasubramanian, Douglas R. Seals, Zachary S. Clayton
Publikováno v:
Experimental Gerontology, Vol 173, Iss , Pp 112105- (2023)
Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffening of the
Externí odkaz:
https://doaj.org/article/00a14a75deac44d691207513daf2dde3
Autor:
Orlando Laitano, Gerard P. Robinson, Kevin O. Murray, Christian K. Garcia, Alex J. Mattingly, Deborah Morse, Michelle A. King, John D. Iwaniec, Jamal M. Alzahrani, Thomas L. Clanton
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Skeletal muscles secrete a wide variety of immunologically active cytokines, but the functional significance of this response to in vivo innate immunity is not understood. We addressed this by knocking out the toll receptor adapter protein,
Externí odkaz:
https://doaj.org/article/00a910c9bab542beb23621aebc00bfec
Autor:
Kevin R Murray, Farid Foroutan, Jennifer M Amadio, Juan Duero Posada, Stella Kozuszko, Joseph Duhamel, Katherine Tsang, Michael E Farkouh, Michael McDonald, Filio Billia, Edward Barber, Steven G Hershman, Mamatha Bhat, Kathryn J Tinckam, Heather J Ross, Christopher McIntosh, Yasbanoo Moayedi
Publikováno v:
JMIR Research Protocols, Vol 10, Iss 10, p e26816 (2021)
BackgroundThe number of solid organ transplants in Canada has increased 33% over the past decade. Hospital readmissions are common within the first year after transplant and are linked to increased morbidity and mortality. Nearly half of these admiss
Externí odkaz:
https://doaj.org/article/04e36db06cee4aaaadbb21dcaaa32ffa