Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Kevin A, Tam"'
Autor:
Kevin J. Tam, Liangliang Liu, Michael Hsing, Kush Dalal, Daksh Thaper, Brian McConeghy, Parvin Yenki, Satyam Bhasin, James W. Peacock, Yuzhuo Wang, Artem Cherkasov, Paul S. Rennie, Martin E. Gleave, Christopher J. Ong
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract FOXA1 is a pioneer transcription factor that is frequently mutated in prostate, breast, bladder, and salivary gland malignancies. Indeed, metastatic castration-resistant prostate cancer (mCRPC) commonly harbour FOXA1 mutations with a prevale
Externí odkaz:
https://doaj.org/article/04472dd65cc24c0c8a00dc7c0f4fd55c
Autor:
James W Peacock, Ario Takeuchi, Norihiro Hayashi, Liangliang Liu, Kevin J Tam, Nader Al Nakouzi, Nastaran Khazamipour, Tabitha Tombe, Takashi Dejima, Kevin CK Lee, Masaki Shiota, Daksh Thaper, Wilson CW Lee, Daniel HF Hui, Hidetoshi Kuruma, Larissa Ivanova, Parvin Yenki, Ivy ZF Jiao, Shahram Khosravi, Alice L‐F Mui, Ladan Fazli, Amina Zoubeidi, Mads Daugaard, Martin E Gleave, Christopher J Ong
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 2, Pp 219-238 (2018)
Abstract Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathway
Externí odkaz:
https://doaj.org/article/2f44866b8d6c48509b92457ef60f92f1
Autor:
Leili Saeednejad Zanjani, Zahra Madjd, Arezoo Rasti, Mojgan Asgari, Maryam Abolhasani, Kevin J. Tam, Raheleh Roudi, Gunhild Mari Mælandsmo, Øystein Fodstad, Yvonne Andersson
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Cancer stem cells (CSCs) are a theorized small subpopulation of cells within tumors thought to be responsible for metastasis, tumor development, disease progression, treatment-resistance, and recurrence. The identification, isolation, and biological
Externí odkaz:
https://doaj.org/article/bda5e2b3d39d41c39eaa51f714164383
Autor:
Paul S. Rennie, Artem Cherkasov, Scott M. Dehm, Daniel T. Gewirth, Martin E. Gleave, Eric LeBlanc, Mani Roshan-Moniri, Kevin J. Tam, Huifang Li, Fuqiang Ban, Ronnie Tse, Deniz Ozistanbullu, Hendrik Borgmann, Nada Lallous, Rendong Yang, Aishwariya Sharma, Nanette S. Que, Meixia Che, Kush Dalal
Supplementary Table S1: Cloning and RT-PCR primers used in this study; Supplementary Figure S1: Luciferase and cell viability experiments with MR49C and PC3 cells; Supplementary Figure S2: ITC control experiment between AR-DBD and dsDNA; Supplementar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3667a690ec42f1ddca067d978fc3db
https://doi.org/10.1158/1535-7163.22508866.v1
https://doi.org/10.1158/1535-7163.22508866.v1
Autor:
Seungpyo Hong, Andrew Z. Wang, Bhishamjit S. Chera, Joel E. Tepper, Tian Zhang, Ronald C. Chen, Colette Shen, Seth M. Miller, Kevin A. Tam, Kyle Wang, Michael J. Poellmann, Sin-Jung Park, Joseph M. Caster, Michael J. Eblan, Ja Hye Myung
Table S1. Clinical and demographic characteristics of recruited cancer patients; Table S2. Demographic characteristics of recruited healthy donors; Figure S1. Reproducibility confirmation of CapioCyte-D by testing duplicated blood samples from three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591a3bcf4b77ce40fa1a6fed30f1d1b3
https://doi.org/10.1158/1078-0432.22464156.v1
https://doi.org/10.1158/1078-0432.22464156.v1
Autor:
Isa Abdi Rad, Maryam Mansoori, Fatemeh Mansouri, Kevin J. Tam, Zahra Madjd, Leili Saeednejad Zanjani, Alireza Mirzaei, Rahim Mahmodlu, Seyed Mohsen Hosseini
Publikováno v:
Journal of Applied Biomedicine. 19:181-189
Cancer stem cells (CSCs) are a theorized subset of cells within the tumor that is thought to drive disease recurrence and metastatic spread. The aim of this study is to investigate mRNA and protein levels of ganglioside GD2 synthase (GD2S), in breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0760c64fca4d626ef0ad99653cbb45e
https://doi.org/10.32725/jab.2021.019
https://doi.org/10.32725/jab.2021.019
Autor:
Ashley S. Cha, Kevin A. Tam, Seungpyo Hong, Ja Hye Myung, Roohollah Sharifi, Gina Votta-Velis, Alain Borgeat, Robert E. Molokie, Michael J. Poellmann
Publikováno v:
Analytical Chemistry. 91:8374-8382
Detection of circulating tumor cells (CTCs) relying on their expression of epithelial cell markers, such as epithelial cell adhesion molecule (EpCAM), has been commonly used. However, this approach unlikely captures CTCs that have undergone the proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88604abc16482057b3d704f04163790e
https://doi.org/10.1021/acs.analchem.9b01181
https://doi.org/10.1021/acs.analchem.9b01181
Autor:
Mark P Labrecque, Mandeep K Takhar, Julienne M Jagdeo, Kevin J Tam, Christina Chiu, Te-Yu Wang, Gratien G Prefontaine, Michael E Cox, Timothy V Beischlag
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99214 (2014)
Localized hypoxia in solid tumors activates transcriptional programs that promote the metastatic transformation of cells. Like hypoxia-inducible hyper-vascularization, loss of the retinoblastoma protein (Rb) is a trait common to advanced stages of tu
Externí odkaz:
https://doaj.org/article/e276625e12064928ae0b5aed567d1aed
Autor:
Mani Roshan-Moniri, Franck Duong, Fuqiang Ban, Hélène Morin, Huifang Li, Kush Dalal, Paul S. Rennie, Christopher J. Ong, Eric Leblanc, Michael Carlson, Kevin J. Tam, Ashley Shepherd, Artem Cherkasov, James W. Peacock, Aishwariya Sharma, Carl Perez
Publikováno v:
Cancer Letters. 437:35-43
Prostate cancer (PCa) is a leading cause of death for men in North America. The androgen receptor (AR) - a hormone inducible transcription factor - drives expression of tumor promoting genes and represents an important therapeutic target in PCa. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f51f40d14929e696740fcff4229767d
https://doi.org/10.1016/j.canlet.2018.08.016
https://doi.org/10.1016/j.canlet.2018.08.016
Autor:
Paul S. Rennie, Nathan A. Lack, Helge Prinz, Eric Leblanc, Kevin J. Tam, Fuqiang Ban, Michael Fernandez, Hélène Morin, Ashley Shepherd, Kush Dalal, Huifang Li, Artem Cherkasov
Publikováno v:
European Journal of Medicinal Chemistry. 157:1164-1173
The androgen receptor (AR) is a hormone-activated transcription factor that regulates the development and progression of prostate cancer (PCa) and represents one of the most well-established drug targets. Currently clinically approved small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed14b9968358fab4efb4f438d889374b
https://doi.org/10.1016/j.ejmech.2018.08.059
https://doi.org/10.1016/j.ejmech.2018.08.059