Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Kevin A, Peterson"'
Autor:
Tracey A. Brereton, MS, Momin M. Malik, PhD, MS, MSc, Lauren M. Rost, PhD, MS, Joshua W. Ohde, PhD, Lu Zheng, PhD, MS, Kristelle A. Jose, MS, Kevin J. Peterson, PhD, MS, David Vidal, JD, Mark A. Lifson, PhD, Joe Melnick, BS, Bryce Flor, BS, Jason D. Greenwood, MD, MS, Kyle Fisher, MPA, Shauna M. Overgaard, PhD
Publikováno v:
Mayo Clinic Proceedings: Digital Health, Vol 2, Iss 2, Pp 246-251 (2024)
Externí odkaz:
https://doaj.org/article/bc76080cddbe46418191df6817137340
Autor:
Guru Subramanian Guru Murthy, Antoine N. Saliba, Aniko Szabo, Alexandra Harrington, Sameem Abedin, Karen Carlson, Laura Michaelis, Lyndsey Runaas, Arielle Baim, Alex Hinman, Sonia Maldonado-Schmidt, Annapoorna Venkatachalam, Karen S. Flatten, Kevin L. Peterson, Paula A. Schneider, Mark Litzow, Scott H. Kaufmann, Ehab Atallah
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Azacitidine/venetoclax is an active regimen in patients with newly diagnosed AML. However, primary or secondary resistance to azacitidine/venetoclax is an area of unmet need and overexpression of MCL-1 is suggested to be a potential resistance mechan
Externí odkaz:
https://doaj.org/article/950acd891d7543f3b377e2a769eccff7
Autor:
Swaathi Jayaraman, Xinyan Wu, Krishna R. Kalari, Xiaojia Tang, Mary J. Kuffel, Elizabeth S. Bruinsma, Shahrzad Jalali, Kevin L. Peterson, Cristina Correia, Rachel A. Kudgus, Scott H. Kaufmann, Santosh Renuse, James N. Ingle, Joel M. Reid, Matthew M. Ames, Alan P. Fields, Matthew J. Schellenberg, John R. Hawse, Akhilesh Pandey, Matthew P. Goetz
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract Endoxifen, a secondary tamoxifen metabolite, is a potent antiestrogen exhibiting estrogen receptor alpha (ERα) binding at nanomolar concentrations. Phase I/II clinical trials identified clinical activity of Z-endoxifen (ENDX), in endocrine-
Externí odkaz:
https://doaj.org/article/809fda6ff0ea4cad83dc611d55814884
Autor:
Aref Al‐Kali, Ibrahim Aldoss, Pamela J. Atherton, Carrie A. Strand, Bijal Shah, Jonathan Webster, Bhavana Bhatnagar, Karen S. Flatten, Kevin L. Peterson, Paula A. Schneider, Sarah A. Buhrow, Jianping Kong, Joel M. Reid, Alex A. Adjei, Scott H. Kaufmann
Publikováno v:
Cancer Medicine, Vol 12, Iss 23, Pp 21229-21239 (2023)
Abstract Background Despite recent approval of several new agents, relapsed acute lymphoblastic leukemia (ALL) remains challenging to treat. Sapanisertib (MLN0128/TAK‐228) is an oral TORC1/2 inhibitor that exhibited preclinical activity against ALL
Externí odkaz:
https://doaj.org/article/55ca42b54be149f0b8acb389ece68dc9
Autor:
Joshua W. Ohde, Momin M. Malik, Shauna M. Overgaard, Tracey A. Brereton, Lu Zheng, Kevin J. Peterson, Lauren M. Rost
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 167-168 (2024)
OBJECTIVES/GOALS: Healthcare sectors are rushing to develop AI models. Yet, a dearth of coordinated practices leaves many teams struggling to implement models into practice. The Enterprise AI Translation Advisory Board uses across-disciplinary team t
Externí odkaz:
https://doaj.org/article/ad6ea10813ed44fbab8d2688780f2fb9
Autor:
Lu Zheng, Joshua W Ohde, Shauna M Overgaard, Tracey A Brereton, Kristelle Jose, Chung-Il Wi, Kevin J Peterson, Young J Juhn
Publikováno v:
JMIR Formative Research, Vol 8, p e45391 (2024)
BackgroundPersonalized asthma management depends on a clinician’s ability to efficiently review patient’s data and make timely clinical decisions. Unfortunately, efficient and effective review of these data is impeded by the varied format, locati
Externí odkaz:
https://doaj.org/article/0b692933a2294f638a63454947037afc
Autor:
Kevin A. Peterson, Sam Khalouei, Nour Hanafi, Joshua A. Wood, Denise G. Lanza, Lauri G. Lintott, Brandon J. Willis, John R. Seavitt, Robert E. Braun, Mary E. Dickinson, Jacqueline K. White, K. C. Kent Lloyd, Jason D. Heaney, Stephen A. Murray, Arun Ramani, Lauryl M. J. Nutter
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Genome editing with CRISPR-associated (Cas) proteins holds exceptional promise for “correcting” variants causing genetic disease. To realize this promise, off-target genomic changes cannot occur during the editing process. Here, we use w
Externí odkaz:
https://doaj.org/article/f7798291f4934fd091966e0b3ee6f881
Autor:
Tracey A Brereton, Momin M Malik, Mark Lifson, Jason D Greenwood, Kevin J Peterson, Shauna M Overgaard
Publikováno v:
Interactive Journal of Medical Research, Vol 12, p e45903 (2023)
BackgroundDespite the touted potential of artificial intelligence (AI) and machine learning (ML) to revolutionize health care, clinical decision support tools, herein referred to as medical modeling software (MMS), have yet to realize the anticipated
Externí odkaz:
https://doaj.org/article/303e2528a04448818c57ebd36ed2e23e
Autor:
Liwei Wang, Huan He, Andrew Wen, Sungrim Moon, Sunyang Fu, Kevin J Peterson, Xuguang Ai, Sijia Liu, Ramakanth Kavuluru, Hongfang Liu
Publikováno v:
JMIR Medical Informatics, Vol 11, p e48072 (2023)
BackgroundA patient’s family history (FH) information significantly influences downstream clinical care. Despite this importance, there is no standardized method to capture FH information in electronic health records and a substantial portion of FH
Externí odkaz:
https://doaj.org/article/82893620b48e4888ac1b74d5c702964e
Autor:
Jonas Malkmus, Laurène Ramos Martins, Shalu Jhanwar, Bonnie Kircher, Victorio Palacio, Rushikesh Sheth, Francisca Leal, Amandine Duchesne, Javier Lopez-Rios, Kevin A. Peterson, Robert Reinhardt, Koh Onimaru, Martin J. Cohn, Aimée Zuniga, Rolf Zeller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit
Externí odkaz:
https://doaj.org/article/8daa3afd4ca340eaad289f8348f3805b