Zobrazeno 1 - 10
of 762
pro vyhledávání: '"Kevin A, Peterson"'
Autor:
Annapoorna Venkatachalam, Cristina Correia, Kevin L. Peterson, Xianon Hou, Paula A. Schneider, Annabella R. Strathman, Karen S. Flatten, Chance C. Sine, Emily A. Balczewski, Cordelia D. McGehee, Melissa C. Larson, Laura N. Duffield, X. Wei Meng, Nicole D. Vincelette, Husheng Ding, Ann L. Oberg, Fergus J. Couch, Elizabeth M. Swisher, Hu Li, S. John Weroha, Scott H. Kaufmann
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Recent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid tumors, including platinum-resistant high grade serous ovarian cancer (HGSOC). Howev
Externí odkaz:
https://doaj.org/article/10416db1db3e4dd388e15b58bcaf44a8
Autor:
Hillary Elrick, Kevin A. Peterson, Brandon J. Willis, Denise G. Lanza, Elif F. Acar, Edward J. Ryder, Lydia Teboul, Petr Kasparek, Marie-Christine Birling, David J. Adams, Allan Bradley, Robert E. Braun, Steve D. Brown, Adam Caulder, Gemma F. Codner, Francesco J. DeMayo, Mary E. Dickinson, Brendan Doe, Graham Duddy, Marina Gertsenstein, Leslie O. Goodwin, Yann Hérault, Lauri G. Lintott, K. C. Kent Lloyd, Isabel Lorenzo, Matthew Mackenzie, Ann-Marie Mallon, Colin McKerlie, Helen Parkinson, Ramiro Ramirez-Solis, John R. Seavitt, Radislav Sedlacek, William C. Skarnes, Damien Smedley, Sara Wells, Jacqueline K. White, Joshua A. Wood, International Mouse Phenotyping Consortium, Stephen A. Murray, Jason D. Heaney, Lauryl M. J. Nutter
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease Cas9 for i
Externí odkaz:
https://doaj.org/article/0788cc9d0e59472c90243baecc221f96
Autor:
Jose K. James, MD, PhD, Tharana Maran, MS, Mindy P. Rice, MBA, Tanner S Hunt, MHA, Kevin J. Peterson, PhD, MS, William J. Hogan, MBBCh, Shivam Damani, BS, Alexander J. Ryu, MD
Publikováno v:
Mayo Clinic Proceedings: Digital Health, Vol 2, Iss 4, Pp 511-514 (2024)
Externí odkaz:
https://doaj.org/article/958ff395b6f84b69adb868f73ebabd33
Autor:
Tracey A. Brereton, MS, Momin M. Malik, PhD, MS, MSc, Lauren M. Rost, PhD, MS, Joshua W. Ohde, PhD, Lu Zheng, PhD, MS, Kristelle A. Jose, MS, Kevin J. Peterson, PhD, MS, David Vidal, JD, Mark A. Lifson, PhD, Joe Melnick, BS, Bryce Flor, BS, Jason D. Greenwood, MD, MS, Kyle Fisher, MPA, Shauna M. Overgaard, PhD
Publikováno v:
Mayo Clinic Proceedings: Digital Health, Vol 2, Iss 2, Pp 246-251 (2024)
Externí odkaz:
https://doaj.org/article/bc76080cddbe46418191df6817137340
Autor:
Swaathi Jayaraman, Xinyan Wu, Krishna R. Kalari, Xiaojia Tang, Mary J. Kuffel, Elizabeth S. Bruinsma, Shahrzad Jalali, Kevin L. Peterson, Cristina Correia, Rachel A. Kudgus, Scott H. Kaufmann, Santosh Renuse, James N. Ingle, Joel M. Reid, Matthew M. Ames, Alan P. Fields, Matthew J. Schellenberg, John R. Hawse, Akhilesh Pandey, Matthew P. Goetz
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract Endoxifen, a secondary tamoxifen metabolite, is a potent antiestrogen exhibiting estrogen receptor alpha (ERα) binding at nanomolar concentrations. Phase I/II clinical trials identified clinical activity of Z-endoxifen (ENDX), in endocrine-
Externí odkaz:
https://doaj.org/article/809fda6ff0ea4cad83dc611d55814884
Autor:
Aref Al‐Kali, Ibrahim Aldoss, Pamela J. Atherton, Carrie A. Strand, Bijal Shah, Jonathan Webster, Bhavana Bhatnagar, Karen S. Flatten, Kevin L. Peterson, Paula A. Schneider, Sarah A. Buhrow, Jianping Kong, Joel M. Reid, Alex A. Adjei, Scott H. Kaufmann
Publikováno v:
Cancer Medicine, Vol 12, Iss 23, Pp 21229-21239 (2023)
Abstract Background Despite recent approval of several new agents, relapsed acute lymphoblastic leukemia (ALL) remains challenging to treat. Sapanisertib (MLN0128/TAK‐228) is an oral TORC1/2 inhibitor that exhibited preclinical activity against ALL
Externí odkaz:
https://doaj.org/article/55ca42b54be149f0b8acb389ece68dc9
Autor:
Guru Subramanian Guru Murthy, Antoine N. Saliba, Aniko Szabo, Alexandra Harrington, Sameem Abedin, Karen Carlson, Laura Michaelis, Lyndsey Runaas, Arielle Baim, Alex Hinman, Sonia Maldonado-Schmidt, Annapoorna Venkatachalam, Karen S. Flatten, Kevin L. Peterson, Paula A. Schneider, Mark Litzow, Scott H. Kaufmann, Ehab Atallah
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Azacitidine/venetoclax is an active regimen in patients with newly diagnosed AML. However, primary or secondary resistance to azacitidine/venetoclax is an area of unmet need and overexpression of MCL-1 is suggested to be a potential resistance mechan
Externí odkaz:
https://doaj.org/article/950acd891d7543f3b377e2a769eccff7
Autor:
Joshua W. Ohde, Momin M. Malik, Shauna M. Overgaard, Tracey A. Brereton, Lu Zheng, Kevin J. Peterson, Lauren M. Rost
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 167-168 (2024)
OBJECTIVES/GOALS: Healthcare sectors are rushing to develop AI models. Yet, a dearth of coordinated practices leaves many teams struggling to implement models into practice. The Enterprise AI Translation Advisory Board uses across-disciplinary team t
Externí odkaz:
https://doaj.org/article/ad6ea10813ed44fbab8d2688780f2fb9
Autor:
Kevin A. Peterson, Sam Khalouei, Nour Hanafi, Joshua A. Wood, Denise G. Lanza, Lauri G. Lintott, Brandon J. Willis, John R. Seavitt, Robert E. Braun, Mary E. Dickinson, Jacqueline K. White, K. C. Kent Lloyd, Jason D. Heaney, Stephen A. Murray, Arun Ramani, Lauryl M. J. Nutter
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Genome editing with CRISPR-associated (Cas) proteins holds exceptional promise for “correcting” variants causing genetic disease. To realize this promise, off-target genomic changes cannot occur during the editing process. Here, we use w
Externí odkaz:
https://doaj.org/article/f7798291f4934fd091966e0b3ee6f881
Autor:
Lu Zheng, Joshua W Ohde, Shauna M Overgaard, Tracey A Brereton, Kristelle Jose, Chung-Il Wi, Kevin J Peterson, Young J Juhn
Publikováno v:
JMIR Formative Research, Vol 8, p e45391 (2024)
BackgroundPersonalized asthma management depends on a clinician’s ability to efficiently review patient’s data and make timely clinical decisions. Unfortunately, efficient and effective review of these data is impeded by the varied format, locati
Externí odkaz:
https://doaj.org/article/0b692933a2294f638a63454947037afc