Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kevin J. Coe"'
Autor:
Christine F. Gelin, Brice Stenne, Heather Coate, Afton Hiscox, Akinola Soyode-Johnson, Jessica L. Wall, Brian Lord, Jeffrey Schoellerman, Kevin J. Coe, Kai Wang, Jesus Alcázar, Christa C. Chrovian, Curt A. Dvorak, Nicholas I. Carruthers, Tatiana Koudriakova, Bartosz Balana, Michael A. Letavic
Publikováno v:
Journal of Medicinal Chemistry. 66:2877-2892
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e473bb48ba527d136d4062091035bc17
https://doi.org/10.1021/acs.jmedchem.2c01916
https://doi.org/10.1021/acs.jmedchem.2c01916
Autor:
Mark S. Tichenor, John J. M. Wiener, Navin L. Rao, Genesis M. Bacani, Jianmei Wei, Charlotte Pooley Deckhut, J. Kent Barbay, Kevin D. Kreutter, Leon Chang, Kathleen W. Clancy, Heather E. Murrey, Weixue Wang, Kay Ahn, Michael Huber, Elizabeth Rex, Kevin J. Coe, Jiejun Wu, Haopeng Rui, Kia Sepassi, Marcello Gaudiano, Mariette Bekkers, Ivo Cornelissen, Kathryn Packman, Mark Seierstad, Christos Xiouras, Scott D. Bembenek, Richard Alexander, Cynthia Milligan, Sriram Balasubramanian, Alec D. Lebsack, Jennifer D. Venable, Ulrike Philippar, James P. Edwards, Gavin Hirst
Publikováno v:
Journal of Medicinal Chemistry. 65:14326-14336
Bruton's tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in leukocytes. Pharmacological inhibition of BTK has been shown to be effective in treating hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b6932f837c19dc6e82c72e8534354a
https://doi.org/10.1021/acs.jmedchem.2c01026
https://doi.org/10.1021/acs.jmedchem.2c01026
Autor:
Jocelyn H. Leu, Xin Miao, Kevin Shalayda, Kevin J. Coe, Ariane Kahnt, Bonnie Wu, Megan Schnarr, Carol Franks, James Devlin, Tong‐Yuan Yang, James A. Palmer, Mai Zhang, Honghui Zhou, Wim Van Damme, Sophie Smets, Zuleima Aguilar, Sandra R. Chaplan
Publikováno v:
Clinical Pharmacology in Drug Development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d4bbe9e75b30d3159200720f0b809dd
https://doi.org/10.1002/cpdd.1253
https://doi.org/10.1002/cpdd.1253
Autor:
Jennifer D. Venable, Weixue Wang, Jianmei Wei, Heather E. Murrey, Mark S. Tichenor, Kristi A. Leonard, Michael Huber, Alec D. Lebsack, Genesis M. Bacani, Scott D. Bembenek, Kay Ahn, J. Kent Barbay, Leon Chang, Kevin D. Kreutter, Navin Rao, Charlotte Pooley Deckhut, Jiejun Wu, Kevin J. Coe, Elizabeth B. Rex, John J. M. Wiener, James P. Edwards, Mark Seierstad
Publikováno v:
ACS Med Chem Lett
[Image: see text] Bruton’s tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in the pathology of autoimmune disorders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422ec59592fb7660a28bf2fbdb3405aa
https://doi.org/10.1021/acsmedchemlett.1c00044
https://doi.org/10.1021/acsmedchemlett.1c00044
Autor:
Alexandra S Needham, Akinola Soyode-Johnson, Kevin J. Coe, Bartosz Balana, Freddy Schoetens, Xiaohui Jiang, Daniel J. Pippel, Kia Sepassi, Chungfang Xia, Stenne Brice M, Brian Scott, Leslie Nguyen, Tatiana Koudriakova, Christa C. Chrovian, Brian Lord, Michael A. Letavic, Jeffrey Schoellerman
Publikováno v:
Journal of Medicinal Chemistry. 63:9181-9196
Selective inhibitors of the GluN2B subunit of N-methyl-d-aspartate receptors in the ionotropic glutamate receptor superfamily have been targeted for the treatment of mood disorders. We sought to identify structurally novel, brain penetrant, GluN2B-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19f1743cefc51ebca30728bea44390f7
https://doi.org/10.1021/acs.jmedchem.9b02113
https://doi.org/10.1021/acs.jmedchem.9b02113
Autor:
Anne E. Fitzgerald, Tatiana Koudriakova, Kevin J. Coe, Anthony Ndifor, Cathy Preville, Christine Dugovic, Neelakandha S. Mani, Nicholas I. Carruthers, Michele C. Rizzolio, Timothy W. Lovenberg, Brock T. Shireman, Diane Nepomuceno, Coate Heather R, Daniel J. Pippel, Brian Lord, Allison Brett Douglas, Curt A. Dvorak, Pascal Bonaventure
Publikováno v:
ACS Med Chem Lett
[Image: see text] The orexin system consists of two neuropeptides (orexin-A and orexin-B) that exert their mode of action on two receptors (orexin-1 and orexin-2). While the role of the orexin-2 receptor is established as an important modulator of sl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b157e2b40c4b8187c17e0918f6f2afc
https://doi.org/10.1021/acsmedchemlett.0c00085
https://doi.org/10.1021/acsmedchemlett.0c00085
Autor:
Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P. Scott, Judy Skaptason, Yuen Tam, Laurie P. Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M. Lim, Michael Hack, Tatiana Koudriakova
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(8)
[4-(4-Methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-yl)pyrimidine-2-amine] (JNJ-2482272), under investigation as an anti-inflammatory agent, was orally administered to rats once daily at 60 mg/kg for 6 consecutive days. Despite high plasma exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7ffacc86d3af23c0c9e8fefda12a2a
https://pubmed.ncbi.nlm.nih.gov/35680134
https://pubmed.ncbi.nlm.nih.gov/35680134
Autor:
Akinola Soyode-Johnson, Michael A. Letavic, Kevin J. Coe, Christa C. Chrovian, Brian Lord, Nicholas I. Carruthers, Wall Jessica L, Bartosz Balana, Xiaohui Jiang, Tatiana Koudriakova, Leslie Nguyen, Jason C. Rech, Jeff Schoellerman
Publikováno v:
ACS Medicinal Chemistry Letters. 10:261-266
Herein, we disclose a series of selective GluN2B negative allosteric modulators containing a 1H-pyrrolo[3,2-b]pyridine core. Lead optimization efforts included increasing brain penetration as well as decreasing cytochrome P450 inhibition and hERG cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::614ed6a6c02beecc62fce4553e7a6304
https://doi.org/10.1021/acsmedchemlett.8b00542
https://doi.org/10.1021/acsmedchemlett.8b00542
Autor:
Tatiana Koudriakova, Devin M. Swanson, Dongpei Wu, Nicholas I. Carruthers, Kevin J. Coe, Timothy W. Lovenberg, Michael K. Ameriks, Mark Seierstad, Beatriz García Olmos, Jorge Vives Martinez, Nyantsz Wu, Brian Lord, Michael P. Maher, Brad M. Savall
Publikováno v:
ACS Medicinal Chemistry Letters. 10:267-272
[Image: see text] This report discloses the discovery and characterization of imidazo[1,2-a]pyrazines and pyrazolo[1,5-c]pyrimidines as selective negative modulators of α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a37968ad3bb58cef4bc92047bc5ff1
https://doi.org/10.1021/acsmedchemlett.8b00599
https://doi.org/10.1021/acsmedchemlett.8b00599
Autor:
Jean E Feagin, Maria Isabel Harrell, Jung C Lee, Kevin J Coe, Bryan H Sands, Jamie J Cannone, Germaine Tami, Murray N Schnare, Robin R Gutell
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38320 (2012)
The mitochondrial genome in the human malaria parasite Plasmodium falciparum is most unusual. Over half the genome is composed of the genes for three classic mitochondrial proteins: cytochrome oxidase subunits I and III and apocytochrome b. The remai
Externí odkaz:
https://doaj.org/article/e4730cdfb5f14681b48d38d4787c1a8b