Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Kevin, Wickman"'
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
IntroductionStress and trauma are significant risk factors for many neuropsychiatric disorders and diseases, including anxiety disorders. Stress-induced anxiety symptoms have been attributed to enhanced excitability in circuits controlling fear, anxi
Externí odkaz:
https://doaj.org/article/00ee864373c4445ab47446946296d706
Autor:
Youjin Oh, Eun-Seon Yoo, Sang Hyeon Ju, Eunha Kim, Seulgi Lee, Seyun Kim, Kevin Wickman, Jong-Woo Sohn
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002252 (2023)
It is well known that the neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase appetite and decrease thermogenesis. Previous studies demonstrated that optogenetic and/or chemogenetic manipulations of NPY/AgRP neuronal activity alter fo
Externí odkaz:
https://doaj.org/article/7d0ef672eebf4fadb1b0eb0244cebc5d
Autor:
Viviana Delgado-Betancourt, Kroekkiat Chinda, Pietro Mesirca, Christian Barrère, Aurélie Covinhes, Laura Gallot, Anne Vincent, Isabelle Bidaud, Sarawut Kumphune, Joël Nargeot, Christophe Piot, Kevin Wickman, Matteo Elia Mangoni, Stéphanie Barrère-Lemaire
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundAcute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Most ischemic episodes are triggered by an increase in heart rate, which induces an imbalance between myocardial oxygen delivery and consumption. De
Externí odkaz:
https://doaj.org/article/a970e246abbf4797bacbe5953a306b1b
Autor:
Kevin Lin, Ya-Chu Chang, Ezequiel Marron Fernandez de Velasco, Kevin Wickman, Chad L. Myers, Anja-Katrin Bielinsky
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101675- (2022)
Summary: Pooled lentiviral CRISPR-Cas9 screens are utilized for assessing the differential sensitivity or resistance of many single-gene knockouts to a compound. Here, we present a scalable approach for high-throughput compound screening by utilizing
Externí odkaz:
https://doaj.org/article/954cde00cbfd4802acf251d0cbe0cfb8
Autor:
Isabelle Bidaud, Alicia D’Souza, Gabriella Forte, Eleonora Torre, Denis Greuet, Steeve Thirard, Cali Anderson, Antony Chung You Chong, Angelo G. Torrente, Julien Roussel, Kevin Wickman, Mark R. Boyett, Matteo E. Mangoni, Pietro Mesirca
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
Background: Endurance athletes are prone to bradyarrhythmias, which in the long-term may underscore the increased incidence of pacemaker implantation reported in this population. Our previous work in rodent models has shown training-induced sinus bra
Externí odkaz:
https://doaj.org/article/2cc2c4e30f3345eab7d6fbf48727ec24
Autor:
Allison Anderson, Kanchan Kulkarni, Ezequiel Marron Fernandez de Velasco, Nicholas Carlblom, Zhilian Xia, Atsushi Nakano, Kirill A. Martemyanov, Elena G. Tolkacheva, Kevin Wickman
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract The atrial G protein-gated inwardly rectifying K+ (GIRK) channel is a critical mediator of parasympathetic influence on cardiac physiology. Here, we probed the details and relevance of the GIRK channel in mouse ventricle. mRNAs for the atria
Externí odkaz:
https://doaj.org/article/88e26c9be7d64664993ca42a8ef00461
Publikováno v:
American journal of physiology. Cell physiology. 323(2)
G protein-gated inwardly rectifying K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3624de6f4f3a75ce335bd6afe7d39a97
https://pubmed.ncbi.nlm.nih.gov/35704701
https://pubmed.ncbi.nlm.nih.gov/35704701
Autor:
Ezequiel Marron Fernandez de Velasco, Lei Zhang, Baovi N. Vo, Megan Tipps, Shannon Farris, Zhilian Xia, Allison Anderson, Nicholas Carlblom, C. David Weaver, Serena M. Dudek, Kevin Wickman
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Many neurotransmitters directly inhibit neurons by activating G protein-gated inwardly rectifying K+ (GIRK) channels, thereby moderating the influence of excitatory input on neuronal excitability. While most neuronal GIRK channels are formed
Externí odkaz:
https://doaj.org/article/71558560ec304bf5a09b60698ab9c399
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C439-C460
G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory influence on neurons. Neuronal GIRK channels mediate the G protein-dependent, direct/postsynaptic inhibitory effect of many neurotransmitters including γ-aminobu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d3c8796f424188ff485b4686b9ea4ed
https://doi.org/10.1152/ajpcell.00102.2022
https://doi.org/10.1152/ajpcell.00102.2022
Autor:
Ezequiel Marron, Megan E. Tipps, Bushra Haider, Tim R. Rose, Baovi N. Vo, Margot C. DeBaker, Kevin Wickman
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Neuropharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a9fb9a608e230ee5d72d33ec661c534
https://doi.org/10.1124/jpet.122.254190
https://doi.org/10.1124/jpet.122.254190