Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Kevin, Wei"'
Autor:
Garrett Dunlap, Aaron Wagner, Nida Meednu, Ruoqiao Wang, Fan Zhang, Jabea Cyril Ekabe, Anna Helena Jonsson, Kevin Wei, Saori Sakaue, Aparna Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Vivian P. Bykerk, Laura T. Donlin, Susan M. Goodman, Gary S. Firestein, David L. Boyle, V. Michael Holers, Larry W. Moreland, Darren Tabechian, Costantino Pitzalis, Andrew Filer, Soumya Raychaudhuri, Michael B. Brenner, Juilee Thakar, Andrew McDavid, Deepak A. Rao, Jennifer H. Anolik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify
Externí odkaz:
https://doaj.org/article/b76b85a9921847d4919133eeb47ed023
Autor:
Kathryn Weinand, Saori Sakaue, Aparna Nathan, Anna Helena Jonsson, Fan Zhang, Gerald F. M. Watts, Majd Al Suqri, Zhu Zhu, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Deepak A. Rao, Jennifer H. Anolik, Michael B. Brenner, Laura T. Donlin, Kevin Wei, Soumya Raychaudhuri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation of the
Externí odkaz:
https://doaj.org/article/6fa32e092ab54daeaadb71dbcca5722d
Autor:
Pooja Prasad, Raj Nagappan, Brian P. Davidson, Kevin Wei, James Hodovan, Jonathan R. Lindner, Johannes Steiner
Publikováno v:
ESC Heart Failure, Vol 10, Iss 5, Pp 3184-3189 (2023)
Abstract Cardiac allograft vasculopathy (CAV) remains a common long‐term complication of cardiac transplantation. While invasive coronary angiography is considered the gold standard, it is also invasive and lacks sensitivity to detect early, distal
Externí odkaz:
https://doaj.org/article/0d8eaaabb5f141148506e7e8673d4c1c
Autor:
Yufei Wang, Jae-Won Cho, Gabriella Kastrunes, Alicia Buck, Cecile Razimbaud, Aedin C. Culhane, Jiusong Sun, David A. Braun, Toni K. Choueiri, Catherine J. Wu, Kristen Jones, Quang-De Nguyen, Zhu Zhu, Kevin Wei, Quan Zhu, Sabina Signoretti, Gordon J. Freeman, Martin Hemberg, Wayne A. Marasco
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108879- (2024)
Summary: One of the major barriers that have restricted successful use of chimeric antigen receptor (CAR) T cells in the treatment of solid tumors is an unfavorable tumor microenvironment (TME). We engineered CAR-T cells targeting carbonic anhydrase
Externí odkaz:
https://doaj.org/article/0c2301842fd04b6197a7bca08f019c78
Autor:
Zhengping Huang, Kailey E. Brodeur, Liang Chen, Du, Holly Wobma, Evan E. Hsu, Meng Liu, Joyce C. Chang, Margaret H. Chang, Janet Chou, Megan Day-Lewis, Fatma Dedeoglu, Olha Halyabar, James A. Lederer, Tianwang Li, Mindy S. Lo, Meiping Lu, Esra Meidan, Jane W. Newburger, Adrienne G. Randolph, Mary Beth Son, Robert P. Sundel, Maria L. Taylor, Huaxiang Wu, Qing Zhou, Scott W. Canna, Kevin Wei, Lauren A. Henderson, Peter A. Nigrovic, Pui Y. Lee
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 22 (2023)
BACKGROUND Macrophage activation syndrome (MAS) is a life-threatening complication of Still’s disease (SD) characterized by overt immune cell activation and cytokine storm. We aimed to further understand the immunologic landscape of SD and MAS.METH
Externí odkaz:
https://doaj.org/article/81b3a17577a741b6be6230b306b10f60
Autor:
Heng-Jia Liu, Heng Du, Damir Khabibullin, Mahsa Zarei, Kevin Wei, Gordon J. Freeman, David J. Kwiatkowski, Elizabeth P. Henske
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
B7-H3 is expressed at high levels in several cancer types and can suppress antitumor immune responses. Here the authors show that B7-H3 expression is dependent on mTORC1 activity and that inhibition of B7-H3 promotes antitumor immunity mediated by cy
Externí odkaz:
https://doaj.org/article/069d521b5d484e92bc51d8086530ba20
Autor:
Wang, Wei1 (AUTHOR) wang.wei1@abbott.com, Tan, Kevin Wei Jie1 (AUTHOR), Chiang, Poh Leong1 (AUTHOR), Wong, Wai Xin1 (AUTHOR), Chen, Wenpu1 (AUTHOR) martin.chen@abbott.com, Lin, Qi1 (AUTHOR) martin.chen@abbott.com
Publikováno v:
Polymers (20734360). Nov2023, Vol. 15 Issue 22, p4424. 15p.
Autor:
Zhengping Huang, Xiaomeng You, Liang Chen, Yan Du, Kailey Brodeur, Hyuk Jee, Qiang Wang, Grace Linder, Roxane Darbousset, Pierre Cunin, Margaret H. Chang, Alexandra Wactor, Brian M. Wauford, Marc J. C. Todd, Kevin Wei, Ying Li, Anais Levescot, Yoichiro Iwakura, Virginia Pascual, Nicole E. Baldwin, Pierre Quartier, Tianwang Li, Maria T. Gianatasio, Robert P. Hasserjian, Lauren A. Henderson, David B. Sykes, Elizabeth D. Mellins, Scott W. Canna, Julia F. Charles, Peter A. Nigrovic, Pui Y. Lee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome. Here the authors implicate the mechanistic target of rapamycin complex 1 in murine mo
Externí odkaz:
https://doaj.org/article/0b6c3e1af33b4a6dbc1260fdb044deab
Publikováno v:
Polymers, Vol 15, Iss 22, p 4424 (2023)
This study investigated the impact of calcium chloride (CaCl2) and magnesium chloride (MgCl2) at varying concentrations on a model milk formulation’s physical and chemical properties after thermal treatment. The model milk was subjected to two-stag
Externí odkaz:
https://doaj.org/article/b15863eb69b94e36becc18c8bad34a2a
Autor:
Amélie M. Julé, Ki Pui Lam, Maria Taylor, Kacie J. Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, Siobhan M. Case, Mia Chandler, Margaret H. Chang, Ezra M. Cohen, Fatma Dedeoglu, Olha Halyabar, Jonathan Hausmann, Melissa M. Hazen, Erin Janssen, Jeffrey Lo, Mindy S. Lo, Esra Meidan, Jordan E. Roberts, Holly Wobma, Mary Beth F. Son, Robert P. Sundel, Pui Y. Lee, Peter T. Sage, Talal A. Chatila, Peter A. Nigrovic, Deepak A. Rao, Lauren A. Henderson
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
T peripheral helper (Tph) cells, identified in the synovium of adults with seropositive rheumatoid arthritis, drive B cell maturation and antibody production in non-lymphoid tissues. We sought to determine if similarly dysregulated T cell-B cell inte
Externí odkaz:
https://doaj.org/article/2e6fb3b7d8f946bf87162e8a9df346f1