Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kevin, Tays"'
Autor:
Zhao Bao-Ping, Kevin Tays, Brad M. Savall, Hui Cai, Michael David Gaul, James P. Edwards, Patricia McGovern, Robin L. Thurmond, Steven P. Meduna
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:956-959
Previously disclosed H 4 receptor modulators, the triamino substituted pyridines and pyrimidines, contain a free primary amino (–NH 2 ) group. In this Letter we demonstrate that an exocyclic amine (NH 2 ) is not needed to maintain affinity, and als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cf34181538e276e7ab511fc51e5e22
https://doi.org/10.1016/j.bmcl.2014.12.027
https://doi.org/10.1016/j.bmcl.2014.12.027
Autor:
Michael D. Hack, Brad M. Savall, Kevin Tays, Paul J. Dunford, Jeffery M. Cowden, Ronald L. Wolin, James P. Edwards, Frank Chavez, Robin L. Thurmond
Publikováno v:
Journal of Medicinal Chemistry. 57:2429-2439
This report discloses the discovery and SAR of a series of 6-alkyl-2-aminopyrimidine derived histamine H4 antagonists that led to the development of JNJ 39758979, which has been studied in phase II clinical trials in asthma and atopic dermatitis. Bui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dfe14322fd77b45e53bd6edd1ac1267
https://doi.org/10.1021/jm401727m
https://doi.org/10.1021/jm401727m
Autor:
Brad M, Savall, Frank, Chavez, Kevin, Tays, Paul J, Dunford, Jeffery M, Cowden, Michael D, Hack, Ronald L, Wolin, Robin L, Thurmond, James P, Edwards
Publikováno v:
Journal of medicinal chemistry. 57(6)
This report discloses the discovery and SAR of a series of 6-alkyl-2-aminopyrimidine derived histamine H4 antagonists that led to the development of JNJ 39758979, which has been studied in phase II clinical trials in asthma and atopic dermatitis. Bui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0d5181ff7c6d468a3e5d73774e28519
https://pubmed.ncbi.nlm.nih.gov/24495018
https://pubmed.ncbi.nlm.nih.gov/24495018
Autor:
Kevin Tays, Jeffrey Atkinson
Publikováno v:
Scopus-Elsevier
The boron trichloride sensitive methoxymethyl (MOM) protecting group has been used to efficiently synthesize polymethoxylated derivatives of the benzoxazinone family of cyclic hydroxamic acids. The MOM group allows the unveiling of the hemiacetal at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdc2c2943f07b8dc25c153e14aac56e
https://doi.org/10.1080/00032719808006490
https://doi.org/10.1080/00032719808006490
Autor:
Kevin Tays, Jeffrey Atkinson
Publikováno v:
ChemInform. 29
The boron trichloride sensitive methoxymethyl (MOM) protecting group has been used to efficiently synthesize polymethoxylated derivatives of the benzoxazinone family of cyclic hydroxamic acids. The MOM group allows the unveiling of the hemiacetal at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0065e1cafc2b18b456b4443e4391eaeb
https://doi.org/10.1002/chin.199826198
https://doi.org/10.1002/chin.199826198