Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kevin, Marley"'
Publikováno v:
Translational Oncology, Vol 8, Iss 4, Pp 231-238 (2015)
BACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evide
Externí odkaz:
https://doaj.org/article/77118137e0a94d0d91f9f1c3dcef374e
Autor:
Shay Bracha, Cheri P. Goodall, Bernadette V. Stang, Patrick E. Chappell, Austin K. Viall, Kevin Marley
Publikováno v:
Veterinary and Comparative Oncology. 14:e31-e44
Serotonin receptor 1B (5HTR1B) traditionally exhibits anti-proliferative activity in osteoblasts. We examined the expression and function of 5HTR1B in the COS canine osteosarcoma cell line and normal canine osteoblasts. Equal levels of 5HTR1B gene an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cde57d8d08ce2fcba9e9d9ec97c4310
https://doi.org/10.1111/vco.12103
https://doi.org/10.1111/vco.12103
Autor:
Bernard Séguin, Guangheng Li, Nicolle E. Hofmann, Atiya Mansoor, Shay Bracha, Charles Keller, Elaine T. Huang, Lara E. Davis, Marc M. Loriaux, Jinu Abraham, John E. Mata, Stuart C. Helfand, Kevin Marley, Jeffrey W. Tyner
Publikováno v:
Pediatric Blood & Cancer. 60:1313-1319
Osteosarcomaisthemostcommonmalignantbonetumor,yettheincidenceofosteosarcomaislowenoughtoposeasignificantbarrierto the timely completion of traditionally designed clinical trials.While research laboratories continue to investigate the underlyingmecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89d670107e6a08ec01bcc7ed6689cd80
https://doi.org/10.1002/pbc.24512
https://doi.org/10.1002/pbc.24512
Publikováno v:
Veterinary and Comparative Oncology. 10:214-222
Canine hemangiosarcoma (HSA) is an endothelial cell malignancy driven, in part, by activating mutations in receptor and non-receptor tyrosine kinases. Proteomics, Western blots and a tyrosine kinase inhibitor were used to elucidate activating mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37d3909e0a5c6e56e2aba1fefbbff247
https://doi.org/10.1111/j.1476-5829.2012.00325.x
https://doi.org/10.1111/j.1476-5829.2012.00325.x
Publikováno v:
Journal of Bone and Mineral Research
Chronic hyperparathyroidism (HPT) is a common cause of metabolic bone disease. These studies investigated the underlying cellular and molecular mechanisms responsible for the detrimental actions of elevated parathyroid hormone (PTH) on the skeleton.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113566dba93d49d859364461fbe4372f
http://europepmc.org/articles/PMC3154003
http://europepmc.org/articles/PMC3154003
Autor:
Brett K. Palama, Avudaiappan Maran, Sutada Lotinun, M. Zhang, Russell T. Turner, Urszula T. Iwaniec, Malcolm B. Lowry, Alexey A. Leontovich, Kristen L. Shogren, Kevin Marley
Publikováno v:
Endocrinology. 149:5735-5746
Abnormal secretion of PTH by the parathyroid glands contributes to a variety of common skeletal disorders. Prior studies implicate platelet-derived growth factor-A (PDGF-A) as an important mediator of selective PTH actions on bone. The present studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f4835878fcdc8816e7fa6961811608
https://doi.org/10.1210/en.2008-0134
https://doi.org/10.1210/en.2008-0134
Publikováno v:
Experimental cell research. 338(1)
Background Osteosarcoma (OS) is an aggressive and often fatal cancer that afflicts over 1000 humans and 10,000 dogs per year in the United States. Recent evidence suggests deregulation in the signaling triad, receptor activator of nuclear factor kapp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7f4238323019e36fa8f49844377d5e
https://pubmed.ncbi.nlm.nih.gov/26254896
https://pubmed.ncbi.nlm.nih.gov/26254896
Publikováno v:
Translational Oncology
Translational Oncology, Vol 8, Iss 4, Pp 231-238 (2015)
Translational Oncology, Vol 8, Iss 4, Pp 231-238 (2015)
BACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bdada322a462dadfbb9dcc5da7089c
https://pubmed.ncbi.nlm.nih.gov/26310368
https://pubmed.ncbi.nlm.nih.gov/26310368
Autor:
John E. Mata, Jennifer M. Simpson, Bernard Séguin, Kevin Marley, William G. Tracewell, Stuart C. Helfand, Shay Bracha, Lisa Brownlee
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidine has been shown to be cytotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e4af0ae573f774ddd1cc0f67438ca6
https://doi.org/10.1186/1756-9966-32-74
https://doi.org/10.1186/1756-9966-32-74
Autor:
Valerie MacDonald, Jeffrey W. Tyner, Erin B. Dickerson, Vidya Schalk, Stuart C. Helfand, Wade Edris, Kevin Marley, Marc M. Loriaux, Brian J. Druker
Publikováno v:
Translational oncology. 6(2)
Hemangiosarcoma, a natural model of human angiosarcoma, is an aggressive vascular tumor diagnosed commonly in dogs. The documented expression of several receptor tyrosine kinases (RTKs) by these tumors makes them attractive targets for therapeutic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6c6fa92759022e49645a286d71b741
https://pubmed.ncbi.nlm.nih.gov/23544168
https://pubmed.ncbi.nlm.nih.gov/23544168