Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Kevin, Liaw"'
Autor:
Carl H June, David Weiner, Christopher A Chuckran, Daniel Park, Ryan P O’Connell, Kevin Liaw, Nils Wellhausen, Pratik S Bhojnagarwala, Devivasha Bordoloi, Nicholas Shupin, Daniel Kulp
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)
Background Advanced clear cell renal cell carcinoma (ccRCC) is a prevalent kidney cancer for which long-term survival rates are abysmal, though immunotherapies are showing potential. Not yet clinically vetted are bispecific T cell engagers (BTEs) tha
Externí odkaz:
https://doaj.org/article/e668ca4eaa1e4321a85a2c4dec2793ca
Autor:
Daniel H. Park, Kevin Liaw, Pratik Bhojnagarwala, Xizhou Zhu, Jihae Choi, Ali R. Ali, Devivasha Bordoloi, Ebony N. Gary, Ryan P. O’Connell, Abhijeet Kulkarni, Diana Guimet, Trevor Smith, Alfredo Perales-Puchalt, Ami Patel, David B. Weiner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 249-263 (2023)
Glioblastoma multiforme (GBM) is among the most difficult cancers to treat with a 5-year survival rate less than 5%. An immunotherapeutic vaccine approach targeting GBM-specific antigen, EGFRvIII, previously demonstrated important clinical impact. Ho
Externí odkaz:
https://doaj.org/article/711f820743e943359c7145d81fe55987
Autor:
Pratik S. Bhojnagarwala, Ryan P. O’Connell, Daniel Park, Kevin Liaw, Ali R. Ali, Devivasha Bordoloi, Joel Cassel, Nicholas J. Tursi, Ebony Gary, David B. Weiner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 289-301 (2022)
Glioblastoma is an aggressive tumor with poor survival rates. Bispecific T cell engagers (BTEs) against different cancers are in various stages of clinical development. Toxicity resulting from cytokine release syndrome and the short half-life of BTEs
Externí odkaz:
https://doaj.org/article/b08d7aa85d8b4282b67badab3aca7d72
Autor:
Xizhou Zhu, Alfredo Perales-Puchalt, Krzysztof Wojtak, Ziyang Xu, Kun Yun, Pratik S. Bhojnagarwala, Devivasha Bordoloi, Daniel H. Park, Kevin Liaw, Mamadou A. Bah, Paul M. Lieberman, Ebony N. Gary, Ami Patel, David B. Weiner
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 218-229 (2022)
Latent Epstein-Barr virus (EBV) infection is associated with several types of cancer. Several clinical studies have targeted EBV antigens as immune therapeutic targets with limited efficacy of EBV malignancies, suggesting that additional targets migh
Externí odkaz:
https://doaj.org/article/f6f4c101657c4f7aa88799ba04927cda
Autor:
Nicholas J. Tursi, Ziyang Xu, Michaela Helble, Susanne Walker, Kevin Liaw, Neethu Chokkalingam, Toshitha Kannan, Yuanhan Wu, Edgar Tello-Ruiz, Daniel H. Park, Xizhou Zhu, Megan C. Wise, Trevor R. F. Smith, Sonali Majumdar, Andrew Kossenkov, Daniel W. Kulp, David B. Weiner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cancer immunotherapy has demonstrated great promise with several checkpoint inhibitors being approved as the first-line therapy for some types of cancer, and new engineered cytokines such as Neo2/15 now being evaluated in many studies. In this work,
Externí odkaz:
https://doaj.org/article/dc3a4e20f8a14ad0a03f68a1e21315d0
Autor:
Devivasha Bordoloi, Pratik S. Bhojnagarwala, Alfredo Perales-Puchalt, Abhijeet J. Kulkarni, Xizhou Zhu, Kevin Liaw, Ryan P. O’Connell, Daniel H. Park, Daniel W. Kulp, Rugang Zhang, David B. Weiner
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Despite advances in ovarian cancer (OC) therapy, recurrent OC remains a poor-prognosis disease. Because of the close interaction between OC cells and the tumor microenvironment (TME), it is important to develop strategies that target tumor cells and
Externí odkaz:
https://doaj.org/article/a607704c926640839bde5206f6333f01
Autor:
Aria C Shi, Elizabeth S Khoury, Nirnath Sah, Amanda Fowler, Kevin Liaw, Anjali Sharma, Rangaramanujam M. Kannan, Sujatha Kannan
Publikováno v:
Precision Nanomedicine, Vol 4, Iss 4 (2021)
Hydroxyl dendrimers target reactive microglia in multiple neuroinflammatory models, including cerebral palsy. Insights on the differential uptake of dendrimers between subpopulations of micro-glia will enable the better design of precise nanomedicine
Externí odkaz:
https://doaj.org/article/90024bdc96c24bcbad7e6746e43df096
Autor:
Ebony N. Gary, Bryce M. Warner, Elizabeth M. Parzych, Bryan D. Griffin, Xizhou Zhu, Nikesh Tailor, Nicholas J. Tursi, Mable Chan, Mansi Purwar, Robert Vendramelli, Jihae Choi, Kathy L. Frost, Sophia Reeder, Kevin Liaw, Edgar Tello, Ali R. Ali, Kun Yun, Yanlong Pei, Sylvia P. Thomas, Amira D. Rghei, Matthew M. Guilleman, Kar Muthumani, Trevor Smith, Sarah K. Wootton, Ami Patel, David B. Weiner, Darwyn Kobasa
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102699- (2021)
Summary: More than 100 million people have been infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Common laboratory mice are not susceptible to wild-type SARS-CoV-2 infection, challenging the development and testing of effec
Externí odkaz:
https://doaj.org/article/c729d41c6d47484fbcc09aab37def4d6
Autor:
Kevin Liaw, Rajsekhar Reddy, Anjali Sharma, Jiangyu Li, Michelle Chang, Rishi Sharma, Sebastian Salazar, Sujatha Kannan, Rangaramanujam M. Kannan
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 2, Pp n/a-n/a (2021)
Abstract Glioblastoma is the most common and aggressive form of primary brain cancer, with median survival of 16–20 months and a 5‐year survival rates of
Externí odkaz:
https://doaj.org/article/d01b3f9afa4447f69a08063ec4f91143
Autor:
Kevin Liaw, Fan Zhang, Antonella Mangraviti, Sujatha Kannan, Betty Tyler, Rangaramanujam M. Kannan
Publikováno v:
Bioengineering & Translational Medicine, Vol 5, Iss 2, Pp n/a-n/a (2020)
Abstract Malignant gliomas are the most common and aggressive form of primary brain tumors, with a median survival of 15–20 months for patients receiving maximal interventions. Advances in nanomedicine have provided tumor‐specific delivery of che
Externí odkaz:
https://doaj.org/article/02e7cc26dd914c4fb5743699aa77cc7f