A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections

Autor: Minyoung Kevin Kim, Qingquan Chen, Arne Echterhof, Nina Pennetzdorfer, Robert C. McBride, Niaz Banaei, Elizabeth B. Burgener, Carlos E. Milla, Paul L. Bollyky

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Bacteriophage (phage) therapy is a promising therapeutic modality for multidrug-resistant bacterial infections, but its application is mainly limited to personalized therapy due to the narrow host range of individual phages. While phage cock

Externí odkaz: https://doaj.org/article/1a0e592dc25140378c37bdb18745f44a

Prognostic performance of the two-step clinical care pathway in metabolic dysfunction-associated steatotic liver disease

Autor: Cheuk-Fung Yip, Terry ^{1, 2, #}, Lee, Hye Won ^{3, #}, Lin, Huapeng ^{4, #}, Tsochatzis, Emmanuel ⁵, Petta, Salvatore ⁶, Bugianesi, Elisabetta ⁷, Yoneda, Masato ⁸, Zheng, Ming-Hua ⁹, Hagström, Hannes ^{10, 11}, Boursier, Jérôme ^{12, 13}, Calleja, José Luis ¹⁴, Boon-Bee Goh, George ¹⁵, Chan, Wah-Kheong ¹⁶, Gallego-Durán, Rocio ¹⁷, Sanyal, Arun J. ¹⁸, de Lédinghen, Victor ¹⁹, Newsome, Philip N. ²⁰, Fan, Jian-Gao ²¹, Castéra, Laurent ²², Lai, Michelle ²³, Fournier-Poizat, Céline ¹⁹, Lai-Hung Wong, Grace ^{1, 2}, Pennisi, Grazia ⁶, Armandi, Angelo ⁷, Nakajima, Atsushi ⁸, Liu, Wen-Yue ²⁴, Shang, Ying ¹⁰, de Saint-Loup, Marc ¹², Llop, Elba ¹⁴, Jun Teh, Kevin Kim ¹⁵, Lara-Romero, Carmen ¹⁷, Asgharpour, Amon ¹⁸, Mahgoub, Sara ²⁵, Sau-Wai Chan, Mandy ¹⁹, Canivet, Clemence M. ^{12, 13}, Romero-Gomez, Manuel ¹⁷, Kim, Seung Up ^{3, ⁎⁎}, Wai-Sun Wong, Vincent ^{1, 2, ⁎}

Publikováno v: In Journal of Hepatology January 2025

Impact of catheter tip to hepatic vein ostium distance on the validity and prognostication of hepatic venous pressure gradient in cirrhosis

Autor: Hiang Keat Tan, Alfred Bingchao Tan, Kevin Kim Jun Teh, Apoorva Gogna, Chow Wei Too, Sum Leong, Jason Pik Eu Chang

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract Hepatic venous pressure gradient (HVPG) is an accurate measure of portal hypertension in cirrhosis. However, the effect of catheter tip distance from hepatic vein ostium (HVO) on HVPG is unknown. We performed a retrospective study on 228 pat

Externí odkaz: https://doaj.org/article/c4b14a43ed7e437099e764e0eadf8226

acFibroMASH Index for the Diagnosis of Fibrotic MASH and Prediction of Liver-related Events: An International Multicenter Study

Autor: Feng, Gong, Mózes, Ferenc E., Ji, Dong, Treeprasertsuk, Sombat, Okanoue, Takeshi, Shima, Toshihide, Liang, Huiqing, Tsochatzis, Emmanuel, Chen, Jinjun, Schattenberg, Jörn M., Labenz, Christian, Mahadeva, Sanjiv, Chan, Wah Kheong, Chi, Xiaoling, Delamarre, Adèle, de Lédinghen, Victor, Petta, Salvatore, Bugianesi, Elisabetta, Hagström, Hannes, Boursier, Jérôme, Calleja, José Luis, Goh, George Boon-Bee, Gallego-Durán, Rocio, Sanyal, Arun J., Fan, Jian-Gao, Castéra, Laurent, Lai, Michelle, Harrison, Stephen A., Romero-Gomez, Manuel, Kim, Seung Up, Zhu, Yongfen, Ooi, Geraldine, Shi, Junping, Yoneda, Masato, Nakajima, Atsushi, Zhang, Jing, Lupsor-Platon, Monica, Zhong, Bihui, Cobbold, Jeremy F.L., Ye, Chun-Yan, Eddowes, Peter J., Newsome, Philip, Li, Jie, George, Jacob, He, Fangping, Song, Myeong Jun, Tang, Hong, Fan, Yuchen, Jia, Jidong, Xu, Liang, Lin, Su, Li, Yiling, Lu, Zhonghua, Nan, Yuemin, Niu, Junqi, Yan, Xuebing, Zhou, Yongjian, Liu, Chenghai, Deng, Hong, Ye, Qing, Zeng, Qing-Lei, Li, Lei, Wang, Jing, Yang, Song, Lin, Huapeng, Lee, Hye Won, Yip, Terry Cheuk-Fung, Fournier-Poizat, Céline, Wong, Grace Lai-Hung, Pennisi, Grazia, Armandi, Angelo, Liu, Wen-Yue, Shang, Ying, de Saint-Loup, Marc, Llop, Elba, Teh, Kevin Kim Jun, Lara-Romero, Carmen, Asgharpour, Amon, Mahgoub, Sara, Chan, Mandy Sau-Wai, Canivet, Clemence M., Ji, Fanpu, Xin, Yongning, Chai, Jin, Dong, Zhiyong, Targher, Giovanni, Byrne, Christopher D., He, Na, Mi, Man, Ye, Feng, Wong, Vincent Wai-Sun, Pavlides, Michael, Zheng, Ming-Hua

Publikováno v: In Clinical Gastroenterology and Hepatology

377 IL-15 treatment enhances the in vivo anti-tumor efficacy of sipuleucel-T by activating CD8+ T and NKT effector cells, augmenting tumor infiltration, and reversing immunoresistance pathways

Autor: Bo Peng, Tuyen Vu, Nadeem Sheikh, Russell Pachynski, Brian Van Tine, Todd Fehniger, Kevin Kim, Muhammad A Saeed, Ariel Borkowski, Daniel Thorek

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/d25bae3ec10c4324954e211797ac2bbc