Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Kevin, J Dawson"'
Autor:
Even H. Rustad, Venkata Yellapantula, Daniel Leongamornlert, Niccolò Bolli, Guy Ledergor, Ferran Nadeu, Nicos Angelopoulos, Kevin J. Dawson, Thomas J. Mitchell, Robert J. Osborne, Bachisio Ziccheddu, Cristiana Carniti, Vittorio Montefusco, Paolo Corradini, Kenneth C. Anderson, Philippe Moreau, Elli Papaemmanuil, Ludmil B. Alexandrov, Xose S. Puente, Elias Campo, Reiner Siebert, Herve Avet-Loiseau, Ola Landgren, Nikhil Munshi, Peter J. Campbell, Francesco Maura
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The initial mutational processes and how these lead to progression in multiple myeloma (MM) are unclear. Here, the authors identify mutational signatures that occur over time in a large cohort of MM patients and suggest features that may help in earl
Externí odkaz:
https://doaj.org/article/5bcecbd98cdc4f9fbf76239987880049
Autor:
Francesco Maura, Niccoló Bolli, Nicos Angelopoulos, Kevin J. Dawson, Daniel Leongamornlert, Inigo Martincorena, Thomas J. Mitchell, Anthony Fullam, Santiago Gonzalez, Raphael Szalat, Federico Abascal, Bernardo Rodriguez-Martin, Mehmet Kemal Samur, Dominik Glodzik, Marco Roncador, Mariateresa Fulciniti, Yu Tzu Tai, Stephane Minvielle, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth C. Anderson, Jose M. C. Tubio, David C. Wedge, Moritz Gerstung, Hervé Avet-Loiseau, Nikhil Munshi, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Multiple myeloma evolves continuously. Here the authors chronologically reconstruct driver events in multiple myeloma, noting a limited repertoire of initiating driver events that shape the evolutionary trajectory of the disease.
Externí odkaz:
https://doaj.org/article/a38608a486ef471e8da57b4ab94d19b3
Autor:
Niccolò Bolli, Francesco Maura, Stephane Minvielle, Dominik Gloznik, Raphael Szalat, Anthony Fullam, Inigo Martincorena, Kevin J. Dawson, Mehmet Kemal Samur, Jorge Zamora, Patrick Tarpey, Helen Davies, Mariateresa Fulciniti, Masood A. Shammas, Yu Tzu Tai, Florence Magrangeas, Philippe Moreau, Paolo Corradini, Kenneth Anderson, Ludmil Alexandrov, David C. Wedge, Herve Avet-Loiseau, Peter Campbell, Nikhil Munshi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Smoldering MM (SMM) is a premalignant stage of multiple myeloma (MM). Here the authors perform whole genome sequencing of unique paired samples of SMM progressing to MM, and show that the genomic landscape at the SMM stage is very similar to MM, but
Externí odkaz:
https://doaj.org/article/7915841302254896b2f39285aed1718f
Autor:
Yvette Hooks, Elizabeth Hook, Luiza Moore, Kenichi Yoshida, Jyoti Nangalia, Peter J. Campbell, Emily Mitchell, Nicholas Williams, Philip S. Robinson, Tim H. H. Coorens, Ana Cvejic, Anna Maria Ranzoni, Michael Spencer Chapman, Brynelle Myers, Kevin J. Dawson, Tim Butler
Publikováno v:
Nature. 595:85-90
The ontogeny of the human haematopoietic system during fetal development has previously been characterized mainly through careful microscopic observations1. Here we reconstruct a phylogenetic tree of blood development using whole-genome sequencing of
Autor:
Michael Spencer Chapman, C. Matthias Wilk, Steffen Boettcher, Emily Mitchell, Kevin J Dawson, Larisa V. Kovtonyuk, Jan Müller, Nicholas Williams, Jyoti Nangalia, Markus G Manz, Peter J. Campbell
Publikováno v:
Blood. 140:1572-1573
Autor:
Nicholas Williams, Joe Lee, Emily Mitchell, Luiza Moore, E. Joanna Baxter, James Hewinson, Kevin J. Dawson, Andrew Menzies, Anna L. Godfrey, Anthony R. Green, Peter J. Campbell, Jyoti Nangalia
Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the timing of driver mutations and subsequent clonal dynamics is limited1-3. Here, using whole-genome sequencing of 1,013 clonal haematopoietic colonies from 12 patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8355060d6c89393b375e89de4a134f27
Autor:
Ferran Nadeu, Romina Royo, Ramon Massoni-Badosa, Beatriz Garcia-Torre, Martí Duran-Ferrer, Kevin J. Dawson, Marta Kulis, Ander Diaz-Navarro, Neus Villamor, Juan L. Melero, Vicente Chapaprieta, Ana Dueso-Barroso, Julio Delgado, Riccardo Moia, Sara Ruiz-Gil, Domenica Marchese, Núria Verdaguer-Dot, Mónica Romo, Maria Rozman, Gerard Frigola, Alfredo Rivas-Delgado, Tycho Baumann, Miguel Alcoceba, Marcos González, Fina Climent, Pau Abrisqueta, Josep Castellví, Francesc Bosch, Marta Aymerich, Anna Enjuanes, Sílvia Ruiz-Gaspà, Armando López-Guillermo, Pedro Jares, Sílvia Beà, Dolors Colomer, Núria López-Bigas, Josep LlGelpí, David Torrents, Peter J. Campbell, Ivo Gut, Pablo M. Garcia-Roves, Davide Rossi, Gianluca Gaidano, Xose S. Puente, Holger Heyn, Francesco Maura, José I. Martín-Subero, Elías Campo
Publikováno v:
Cancer Research. 82:3795-3795
Introduction: Clonal evolution drives cancer development due to the emergence and/or selection of proliferatively advantageous subclones. Its understanding may facilitate the design of anticipation-based management strategies. Richter transformation
Autor:
Stefan C. Dentro, Ignaty Leshchiner, Kerstin Haase, Maxime Tarabichi, Jeff Wintersinger, Amit G. Deshwar, Kaixian Yu, Yulia Rubanova, Geoff Macintyre, Jonas Demeulemeester, Ignacio Vázquez-García, Kortine Kleinheinz, Dimitri G. Livitz, Salem Malikic, Nilgun Donmez, Subhajit Sengupta, Pavana Anur, Clemency Jolly, Marek Cmero, Daniel Rosebrock, Steven E. Schumacher, Yu Fan, Matthew Fittall, Ruben M. Drews, Xiaotong Yao, Thomas B.K. Watkins, Juhee Lee, Matthias Schlesner, Hongtu Zhu, David J. Adams, Nicholas McGranahan, Charles Swanton, Gad Getz, Paul C. Boutros, Marcin Imielinski, Rameen Beroukhim, S. Cenk Sahinalp, Yuan Ji, Martin Peifer, Inigo Martincorena, Florian Markowetz, Ville Mustonen, Ke Yuan, Moritz Gerstung, Paul T. Spellman, Wenyi Wang, Quaid D. Morris, David C. Wedge, Peter Van Loo, Santiago Gonzalez, David D. Bowtell, Peter J. Campbell, Shaolong Cao, Elizabeth L. Christie, Yupeng Cun, Kevin J. Dawson, Roland Eils, Dale W. Garsed, Gavin Ha, Lara Jerman, Henry Lee-Six, Thomas J. Mitchell, Layla Oesper, Myron Peto, Benjamin J. Raphael, Adriana Salcedo, Ruian Shi, Seung Jun Shin, Lincoln D. Stein, Oliver Spiro, Shankar Vembu, David A. Wheeler, Tsun-Po Yang
Publikováno v:
Cell, vol 184, iss 8
PCAWG Evolution and Heterogeneity Working Group, PCAWG Consortium & Wedge, D C 2021, ' Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes ', Cell, vol. 184, no. 8, pp. 2239-2254.e39 . https://doi.org/10.1016/j.cell.2021.03.009
Cell
PCAWG Evolution and Heterogeneity Working Group, PCAWG Consortium & Wedge, D C 2021, ' Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes ', Cell, vol. 184, no. 8, pp. 2239-2254.e39 . https://doi.org/10.1016/j.cell.2021.03.009
Cell
Summary Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an important clinical challenge. However, the extent, origin, and drivers of ITH across cancer types are poorly understood. To address this, we extensively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb531f63564192b68acc8f428aac07cd
http://hdl.handle.net/10138/330238
http://hdl.handle.net/10138/330238
Autor:
Inigo Martincorena, Ruben VanBoxtel, Kevin J. Dawson, Anne Y. Warren, Calli Latimer, Andrew Menzies, Peter J. Campbell, Thomas R. W. Oliver, Michael R. Stratton, Matthew D. C. Neville, Luiza Moore, Raheleh Rahbari, Laura O’Neill, Mette Jorgensen, Tim H. H. Coorens, Mabel J Teng, Rebecca C. Fitzgerald, Yvette Hooks, Tim Butler, Alex Cagan, Ayesha Noorani, Rashesh Sanghvi, Christine A. Iacobuzio-Donahue, Daniel Leongamornlert, Rakesh Heer, Mathijs A. Sanders, Thomas J. Mitchell, Peter R. Ellis
During the course of a lifetime normal human cells accumulate mutations. Here, using multiple samples from the same individuals we compared the mutational landscape in 29 anatomical structures from soma and the germline. Two ubiquitous mutational sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db4c6d1f5200964840de84cc28192034
https://doi.org/10.1101/2020.11.25.398172
https://doi.org/10.1101/2020.11.25.398172
Autor:
Thomas R. W. Oliver, Tim H. H. Coorens, Rakesh Heer, Kevin J. Dawson, Mabel J Teng, Daniel Leongamornlert, Ruben van Boxtel, Calli Latimer, Michael R. Stratton, Rashesh Sanghvi, Ayesha Noorani, Raheleh Rahbari, Inigo Martincorena, Laura O’Neill, Thomas J. Mitchell, Mathijs A. Sanders, Mette Jorgensen, Matthew D. C. Neville, Rebecca C. Fitzgerald, Peter R. Ellis, Christine A. Iacobuzio-Donahue, Alex Cagan, Andrew Menzies, Peter J. Campbell, Tim Butler, Yvette Hooks, Luiza Moore, Anne Y. Warren
Publikováno v:
Nature, 597(7876), 381-386. Nature Publishing Group
Over the course of an individual’s lifetime, normal human cells accumulate mutations1. Here we compare the mutational landscape in 29 cell types from the soma and germline using multiple samples from the same individuals. Two ubiquitous mutational