Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Kevin, Holden"'
Autor:
Alice Mac Kain, Ghizlane Maarifi, Sophie-Marie Aicher, Nathalie Arhel, Artem Baidaliuk, Sandie Munier, Flora Donati, Thomas Vallet, Quang Dinh Tran, Alexandra Hardy, Maxime Chazal, Françoise Porrot, Molly OhAinle, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Gert Zimmer, Etienne Simon-Lorière, Timothée Bruel, Olivier Schwartz, Sylvie van der Werf, Nolwenn Jouvenet, Sébastien Nisole, Marco Vignuzzi, Ferdinand Roesch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Here, Mac Kain and Maarifi et al. perform a functional CRISPR/Cas9 screen to identify SARS-CoV-2 restriction factors in A549 cells. They identify DAXX, a scaffold protein of nuclear bodies with diverse functions, that has anti-viral activity post SAR
Externí odkaz:
https://doaj.org/article/2979f6b8098645b5aa9271d3426c5eed
Autor:
Leiping Zeng, Yanxia Liu, Xammy Huu Nguyenla, Timothy R. Abbott, Mengting Han, Yanyu Zhu, Augustine Chemparathy, Xueqiu Lin, Xinyi Chen, Haifeng Wang, Draven A. Rane, Jordan M. Spatz, Saket Jain, Arjun Rustagi, Benjamin Pinsky, Adrianna E. Zepeda, Anastasia P. Kadina, John A. Walker, Kevin Holden, Nigel Temperton, Jennifer R. Cochran, Annelise E. Barron, Michael D. Connolly, Catherine A. Blish, David B. Lewis, Sarah A. Stanley, Marie F. La Russa, Lei S. Qi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here the authors show that CRISPR-Cas13d can be used as a broad-spectrum antiviral to inhibit human coronaviruses, including new SARS-CoV
Externí odkaz:
https://doaj.org/article/b19524c1f85b4105af7741efdca8ff41
Autor:
Pan Gao, Qing Lyu, Amr R. Ghanam, Cicera R. Lazzarotto, Gregory A. Newby, Wei Zhang, Mihyun Choi, Orazio J. Slivano, Kevin Holden, John A. Walker, Anastasia P. Kadina, Rob J. Munroe, Christian M. Abratte, John C. Schimenti, David R. Liu, Shengdar Q. Tsai, Xiaochun Long, Joseph M. Miano
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Most single nucleotide variants (SNVs) occur in noncoding sequence where millions of transcription factor binding sites (TFBS) reside. Here, a comparative analysis of CRISPR-mediated homology-directed repair (HDR) versus the recen
Externí odkaz:
https://doaj.org/article/3ae7242cf5e844faa32def1a4de9bd76
Autor:
Matthew T. N. Yarnall, Eleonora I. Ioannidi, Cian Schmitt-Ulms, Rohan N. Krajeski, Justin Lim, Lukas Villiger, Wenyuan Zhou, Kaiyi Jiang, Sofya K. Garushyants, Nathaniel Roberts, Liyang Zhang, Christopher A. Vakulskas, John A. Walker, Anastasia P. Kadina, Adrianna E. Zepeda, Kevin Holden, Hong Ma, Jun Xie, Guangping Gao, Lander Foquet, Greg Bial, Sara K. Donnelly, Yoshinari Miyata, Daniel R. Radiloff, Jordana M. Henderson, Andrew Ujita, Omar O. Abudayyeh, Jonathan S. Gootenberg
Publikováno v:
Nat Biotechnol
Programmable genome integration of large, diverse DNA cargo without DNA repair of exposed DNA double-strand breaks remains an unsolved challenge in genome editing. We present programmable addition via site-specific targeting elements (PASTE), which u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f0141730000285cf08335780ce35c5
https://doi.org/10.1038/s41587-022-01527-4
https://doi.org/10.1038/s41587-022-01527-4
Autor:
David, Conant, Tim, Hsiau, Nicholas, Rossi, Jennifer, Oki, Travis, Maures, Kelsey, Waite, Joyce, Yang, Sahil, Joshi, Reed, Kelso, Kevin, Holden, Brittany L, Enzmann, Rich, Stoner
Publikováno v:
The CRISPR Journal. 5:123-130
Efficient and precise genome editing requires a fast, quantitative, and inexpensive assay to assess genotype following editing. Here, we present ICE (Inference of CRISPR Edits), which enables robust analysis of CRISPR edits using Sanger data. ICE pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c33983379b795399534b18584dfdd21
https://doi.org/10.1089/crispr.2021.0113
https://doi.org/10.1089/crispr.2021.0113
Autor:
Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn Jang, Jiewei Xu, Jack M. Moen, Alicia L. Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, Giuditta De Lorenzo, Vanessa Cowton, Abdullah M. Syed, Alison Ciling, Noa Deutsch, Daniel Pirak, Giulia Dowgier, Dejan Mesner, Jane L. Turner, Briana L. McGovern, M. Luis Rodriguez, Rocio Leiva-Rebollo, Alistair S. Dunham, Xiaofang Zhong, Manon Eckhardt, Andrea Fossati, Nicholas Liotta, Thomas Kehrer, Anastasija Cupic, Magda Rutkowska, Nacho Mena, Sadaf Aslam, Alyssa Hoffert, Helene Foussard, Charles Olwal, Weiqing Huang, Thomas Zwaka, John Pham, Molly Lyons, Laura Donohue, Aliesha Griffin, Rebecca Nugent, Kevin Holden, Robert Deans, Pablo Aviles, José Antonio López, José María Jimeno Doñaque, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Ruth Hüttenhain, Irwin Jungreis, Manolis Kellis, Ignacia Echeverria, Kliment Verba, Paola Bonfanti, Pedro Beltrao, Roded Sharan, Jennifer A. Doudna, Luis Martinez-Sobrido, Arvind Patel, Massimo Palmarini, Lisa Miorin, Kris White, Danielle L. Swaney, Adolfo Garcia-Sastre, Clare Jolly, Lorena Zuliani-Alvarez, Greg J. Towers, Nevan J. Krogan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1fac14fca4140ce96becc2c3766070b
https://doi.org/10.2139/ssrn.4319535
https://doi.org/10.2139/ssrn.4319535
Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories
Autor:
Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn M. Jang, Jiewei Xu, Jack M. Moen, Alicia Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, Giuditta De Lorenzo, Vanessa Cowton, Abdullah M. Syed, Alison Ciling, Noa Deutsch, Daniel Pirak, Giulia Dowgier, Dejan Mesner, Jane L. Turner, Briana L. McGovern, M. Luis Rodriguez, Rocio Leiva-Rebollo, Alistair S. Dunham, Xiaofang Zhong, Manon Eckhardt, Andrea Fossati, Nicholas Liotta, Thomas Kehrer, Anastasija Cupic, Magda Rutkowska, Nacho Mena, Sadaf Aslam, Alyssa Hoffert, Helene Foussard, John Pham, Molly Lyons, Laura Donahue, Aliesha Griffin, Rebecca Nugent, Kevin Holden, Robert Deans, Pablo Aviles, José Antonio López-Martín, Jose M. Jimeno, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Ruth Hüttenhain, Irwin Jungreis, Manolis Kellis, Ignacia Echeverria, Kliment Verba, Paola Bonfanti, Pedro Beltrao, Roded Sharan, Jennifer A. Doudna, Luis Martinez-Sobrido, Arvind Patel, Massimo Palmarini, Lisa Miorin, Kris White, Danielle L. Swaney, Adolfo García-Sastre, Clare Jolly, Lorena Zuliani-Alvarez, Greg J. Towers, Nevan J. Krogan
A series of SARS-CoV-2 variants of concern (VOCs) have evolved in humans during the COVID-19 pandemic—Alpha, Beta, Gamma, Delta, and Omicron. Here, we used global proteomic and genomic analyses during infection to understand the molecular responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c8567a33da825246dd5aa0c0571375e
https://doi.org/10.1101/2022.10.19.512927
https://doi.org/10.1101/2022.10.19.512927
Autor:
Alyna Katti, Miguel Foronda, Jill Zimmerman, Maria Paz Zafra, Sukanya Goswami, Eric E. Gardner, Bianca J. Diaz, Janelle M Simon, Alexandra Wuest, Wei Luan, Maria Teresa Calvo Fernandez, Anastasia P. Kadina, John A Walker, Kevin Holden, Francisco J. Sánchez Rivera, Scott W. Lowe, Lukas E. Dow
Single nucleotide variants (SNVs) comprise the majority of cancer-associated genetic changes and can have diverse effects on protein function. Despite a comprehensive catalogue of SNVs across human cancers, little is known about their impact on tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fec9ba11c8e8fb46e7976b5250627dbf
https://doi.org/10.1101/2022.08.03.502708
https://doi.org/10.1101/2022.08.03.502708
Autor:
Irene P. Chen, James E. Longbotham, Sarah McMahon, Rahul K. Suryawanshi, Mir M. Khalid, Taha Y. Taha, Takako Tabata, Jennifer M. Hayashi, Frank W. Soveg, Jared Carlson-Stevermer, Meghna Gupta, Meng Yao Zhang, Victor L. Lam, Yang Li, Zanlin Yu, Erron W. Titus, Amy Diallo, Jennifer Oki, Kevin Holden, Nevan Krogan, Danica Galonić Fujimori, Melanie Ott
Publikováno v:
Cell reports, vol 40, iss 3
bioRxiv
bioRxiv
Inhibitors of bromodomain and extraterminal domain (BET) proteins are possible anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylactics as they downregulate angiotensin-converting enzyme 2 (ACE2). Here we show that BET proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5372b20c38023d14b59bc671f5a2a48
https://escholarship.org/uc/item/2pf842c8
https://escholarship.org/uc/item/2pf842c8
Autor:
Andreas E. Moor, Nina Frey, Ying K. Tam, Denis V Victorov, Costanza Borrelli, Kevin Holden, Melissa K Dennis, Martin Jinek, Dominik Witzigmann, Rurika Oka, Susanne Kreutzer, Lukas Villiger, Gerald Schwank, Martina Hruzova, Lucas Kissling, Norbert Pardi, Daniela Lenggenhager, Markus Stoffel, Ruben van Boxtel, Zacharias Kontarakis, Beat Thöny, Sean C. Semple, Anastasia P. Kadina, John A. Walker, Johannes Häberle, Sabina Egli, Tanja Rothgangl, Noëlle Bakker, Martin Pacesa, Weihong Qi, Paulo J.C. Lin, Drew Weissman
Publikováno v:
Nature Biotechnology, 39 (8)
Nature Biotechnology
Nature biotechnology, 39(August 2021). Nature Publishing Group
Nature Biotechnology
Nature biotechnology, 39(August 2021). Nature Publishing Group
Most known pathogenic point mutations in humans are C center dot G to T center dot A substitutions, which can be directly repaired by adenine base editors (ABEs). In this study, we investigated the efficacy and safety of ABEs in the livers of mice an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ae069a0668f90ce5cdbb49415cc632
https://doi.org/10.1038/s41587-021-00933-4
https://doi.org/10.1038/s41587-021-00933-4