Zobrazeno 1 - 10
of 705
pro vyhledávání: '"Kevin, Eggan"'
Autor:
Matthew Tegtmeyer, Jatin Arora, Samira Asgari, Beth A. Cimini, Ajay Nadig, Emily Peirent, Dhara Liyanage, Gregory P. Way, Erin Weisbart, Aparna Nathan, Tiffany Amariuta, Kevin Eggan, Marzieh Haghighi, Steven A. McCarroll, Luke O’Connor, Anne E. Carpenter, Shantanu Singh, Ralda Nehme, Soumya Raychaudhuri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The morphology of cells is dynamic and mediated by genetic and environmental factors. Characterizing how genetic variation impacts cell morphology can provide an important link between disease association and cellular function. Here, we comb
Externí odkaz:
https://doaj.org/article/dc42a670937d4904a022a638c2d79798
Autor:
Ellen J. Guss, Laila Sathe, Alexander Dai, Tim Derebenskiy, Ana Rodriguez Vega, Kevin Eggan, Michael F. Wells
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102878- (2024)
Summary: Human pluripotent stem cell-derived neural progenitor cells (NPCs) are an essential tool for the study of brain development and developmental disorders such as autism. Here, we present a protocol to generate NPCs rapidly and reproducibly fro
Externí odkaz:
https://doaj.org/article/b3cd8ded106c4302b87c41c20dab8227
Publikováno v:
The Quarterly Review of Biology, 2008 Mar . 83(1), 142-142.
Externí odkaz:
https://www.jstor.org/stable/10.1086/587005
Autor:
Lynne Lederman
Publikováno v:
BioTechniques, Vol 41, Iss 4, p 371 (2006)
Externí odkaz:
https://doaj.org/article/d80f61e32b41404aa52d107ac12b83cf
Autor:
Ralda Nehme, Olli Pietiläinen, Mykyta Artomov, Matthew Tegtmeyer, Vera Valakh, Leevi Lehtonen, Christina Bell, Tarjinder Singh, Aditi Trehan, John Sherwood, Danielle Manning, Emily Peirent, Rhea Malik, Ellen J. Guss, Derek Hawes, Amanda Beccard, Anne M. Bara, Dane Z. Hazelbaker, Emanuela Zuccaro, Giulio Genovese, Alexander A. Loboda, Anna Neumann, Christina Lilliehook, Outi Kuismin, Eija Hamalainen, Mitja Kurki, Christina M. Hultman, Anna K. Kähler, Joao A. Paulo, Andrea Ganna, Jon Madison, Bruce Cohen, Donna McPhie, Rolf Adolfsson, Roy Perlis, Ricardo Dolmetsch, Samouil Farhi, Steven McCarroll, Steven Hyman, Ben Neale, Lindy E. Barrett, Wade Harper, Aarno Palotie, Mark Daly, Kevin Eggan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
How the 22q11.2 deletion predisposes to psychiatric disease is unclear. Here, the authors examine living human neuronal cells and show that 22q11.2 regulates the expression of genes linked to autism during early development, and genes linked to schiz
Externí odkaz:
https://doaj.org/article/0268f31356f54488b25b24160fcce4bc
Autor:
Mian Wang, Wanlu Li, Jin Hao, Arthur Gonzales, Zhibo Zhao, Regina Sanchez Flores, Xiao Kuang, Xuan Mu, Terry Ching, Guosheng Tang, Zeyu Luo, Carlos Ezio Garciamendez-Mijares, Jugal Kishore Sahoo, Michael F. Wells, Gengle Niu, Prajwal Agrawal, Alfredo Quiñones-Hinojosa, Kevin Eggan, Yu Shrike Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Soft tissue fabrication using digital light processing remains challenging. Here the authors present a molecular cleavage approach to achieve high-performance bioprinting of constructs with tissue-matching mechanical properties and structural complex
Externí odkaz:
https://doaj.org/article/5d26ccbb62cb4fad94e21e8efb0c30dd
Autor:
Olli Pietiläinen, Aditi Trehan, Daniel Meyer, Jana Mitchell, Matthew Tegtmeyer, Vera Valakh, Hilena Gebre, Theresa Chen, Emilia Vartiainen, Samouil L. Farhi, Kevin Eggan, Steven A. McCarroll, Ralda Nehme
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111988- (2023)
Summary: The maturation of neurons and the development of synapses, although emblematic of neurons, also relies on interactions with astrocytes and other glia. Here, to study the role of glia-neuron interactions, we analyze the transcriptomes of huma
Externí odkaz:
https://doaj.org/article/3bb532734e46402abb8d76c949a62d41
Autor:
Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark, Amnon Koren
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The genetic basis of how cells replicate their DNA is not well understood. Here, the authors identify >1000 genetic elements that control human replication and reveal a complex epigenetic system that regulates replication origin activities.
Externí odkaz:
https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
Autor:
Ator Ashoti, Francesco Limone, Melissa van Kranenburg, Anna Alemany, Mirna Baak, Judith Vivié, Frederica Piccioni, Pascale F. Dijkers, Menno Creyghton, Kevin Eggan, Niels Geijsen
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Genome-wide screens that have viability as a readout have been instrumental to identify essential genes. The development of gene knockout screens with the use of CRISPR-Cas has provided a more sensitive method to identify these genes. Here, we perfor
Externí odkaz:
https://doaj.org/article/7a34dd889a6644cbac3dc84f3a0a657a
Autor:
Werner Neuhausser, Hyung Oh, Pierce Eggan, Magdalena Angelova, Rory Kirchner, Kevin Eggan, David Knipe
Publikováno v:
Bio-Protocol, Vol 10, Iss 17 (2020)
The efficiency of cleavage of individual CRISPR/Cas9-sgRNAs remains difficult to predict based on the CRISPR target sequence alone. Different intracellular environments (dependent on cell type or cell cycle state for example) may affect sgRNA efficie
Externí odkaz:
https://doaj.org/article/7a09d2e220fe4acfa7caff8539b9e0d9