Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Kevin, Dhaliwal"'
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract The COVID-19 pandemic has highlighted the importance of efficient drug discovery in respiratory disease. The traditional set up of clinical trials is expensive and allows for significant attrition of new drugs, many of which undergo extensiv
Externí odkaz:
https://doaj.org/article/8ac80f945eeb4d6880f8470487d1661b
Autor:
Bharti Wadhwa, Vikas Malhotra, Sukhyanti Kerai, Farah Husain, Nalini Bala Pandey, Kirti N. Saxena, Vinay Singh, Tom M. Quinn, Feng Li, Erin Gaughan, Manu Shankar-Hari, Bethany Mills, Jean Antonelli, Annya Bruce, Keith Finlayson, Anne Moore, Kevin Dhaliwal, Christopher Edwards
Publikováno v:
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-10 (2023)
Abstract Background In this phase 2 randomised placebo-controlled clinical trial in patients with COVID-19, we hypothesised that blocking mineralocorticoid receptors using a combination of dexamethasone to suppress cortisol secretion and spironolacto
Externí odkaz:
https://doaj.org/article/cf1e252869164b8182b3068b57cb21f4
Autor:
Qiang Wang, Susan Fernandes, Gareth O. S. Williams, Neil Finlayson, Ahsan R. Akram, Kevin Dhaliwal, James R. Hopgood, Marta Vallejo
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Using unsupervised image-to-image synthesis, homography regression-based co-registration of fluorescence-histology images is improved and can be used on various image formats across full-spectral emission wavelengths.
Externí odkaz:
https://doaj.org/article/b24dfb20d33d4c10a0cf1a596915b6c0
Autor:
Helen F. Titmarsh, Alex von Kriegsheim, Jimi C. Wills, Richard A. O’Connor, Kevin Dhaliwal, Margaret C. Frame, Samuel B. Pattle, David A. Dorward, Adam Byron, Ahsan R. Akram
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and restricting anti-tumour therapies through mult
Externí odkaz:
https://doaj.org/article/7b547f7e40124ff7826557da8efed3d7
Autor:
Duncan C. Humphries, Richard A. O’Connor, Hazel L. Stewart, Tom M. Quinn, Erin E. Gaughan, Beth Mills, Gareth O.S. Williams, James M. Stone, Keith Finlayson, Martine Chabaud-Riou, Florence Boudet, Kevin Dhaliwal, Vincent Pavot
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPulmonary-resident memory T cells (TRM) and B cells (BRM) orchestrate protective immunity to reinfection with respiratory pathogens. Developing methods for the in situ detection of these populations would benefit both research and clinica
Externí odkaz:
https://doaj.org/article/3f4db45336fc448c8b477921e7dd0a20
Autor:
Alicia Megia-Fernandez, Adam Marshall, Ahsan R. Akram, Bethany Mills, Sunay V. Chankeshwara, Emma Scholefield, Amy Miele, Bruce C. McGorum, Chesney Michaels, Nathan Knighton, Tom Vercauteren, Francois Lacombe, Veronique Dentan, Annya M. Bruce, Joanne Mair, Robert Hitchcock, Nik Hirani, Chris Haslett, Mark Bradley, Kevin Dhaliwal
Publikováno v:
BME Frontiers, Vol 4 (2023)
Externí odkaz:
https://doaj.org/article/d9406fd63d58453dae32886b9ba0b5eb
Autor:
Pablo Roldán-Varona, Calum A. Ross, Luis Rodríguez-Cobo, José Miguel López-Higuera, Erin Gaughan, Kevin Dhaliwal, Michael G. Tanner, Robert R. Thomson, Helen E. Parker
Publikováno v:
APL Photonics, Vol 8, Iss 1, Pp 016103-016103-12 (2023)
Imaging fibers are used to perform real-time fluorescence endomicroscopy, in vivo, in situ, with the goal of increasing diagnostic information for a plethora of organ systems and diseases. Widefield fiber endomicroscopy systems are simple, cost-effec
Externí odkaz:
https://doaj.org/article/0408c08d7f524544883d462d57a41026
Autor:
Megan Neary, Joanne Sharp, Eduardo Gallardo-Toledo, Joanne Herriott, Edyta Kijak, Chloe Bramwell, Helen Cox, Lee Tatham, Helen Box, Paul Curley, Usman Arshad, Rajith K. R. Rajoli, Henry Pertinez, Anthony Valentijn, Kevin Dhaliwal, Frank Mc Caughan, James Hobson, Steve Rannard, Anja Kipar, James P. Stewart, Andrew Owen
Publikováno v:
Viruses, Vol 15, Iss 8, p 1744 (2023)
The successful development of a chemoprophylaxis against SARS-CoV-2 could provide a tool for infection prevention that is implementable alongside vaccination programmes. Nafamostat is a serine protease inhibitor that inhibits SARS-CoV-2 entry in vitr
Externí odkaz:
https://doaj.org/article/24438ca2f944447a88cab0056c860073
Autor:
Basem Al-Omari, Peter McMeekin, A. Joy Allen, Ahsan R. Akram, Sara Graziadio, Jana Suklan, William S. Jones, B. Clare Lendrem, Amanda Winter, Milo Cullinan, Joanne Gray, Kevin Dhaliwal, Timothy S. Walsh, Thomas H. Craven
Publikováno v:
BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-19 (2021)
Abstract Background Ventilator-associated pneumonia (VAP) is an important diagnosis in critical care. VAP research is complicated by the lack of agreed diagnostic criteria and reference standard test criteria. Our aim was to review which reference st
Externí odkaz:
https://doaj.org/article/f166d0cc443c4acba4b4c4623c490046
Autor:
Thomas H. Craven, Tashfeen Walton, Ahsan R. Akram, Emma Scholefield, Neil McDonald, Adam D.L. Marshall, Duncan C. Humphries, Bethany Mills, Thane A. Campbell, Annya Bruce, Joanne Mair, James W. Dear, David E. Newby, Adam T. Hill, Timothy S. Walsh, Chris Haslett, Kevin Dhaliwal
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neutrophil activation is an integral process to acute inflammation and is associated with adverse clinical sequelae. Identification of neutrophil activation in real time in the lungs of patients may permit biological stratification of patien
Externí odkaz:
https://doaj.org/article/e52c1d397194451fb7aab2ac97bdda7d