Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Keven R. Johnson"'
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132474 (2015)
In the heart, scaffolding proteins such as A-Kinase Anchoring Proteins (AKAPs) play a crucial role in normal cellular function by serving as a signaling hub for multiple protein kinases including protein kinase D1 (PKD1). Under cardiac hypertrophic c
Externí odkaz:
https://doaj.org/article/9fe7c9ea9ab04da79d951301ae5e2d78
Autor:
Keven R. Johnson, Andrei V. Karginov, Randal A. Skidgel, John P. O'Bryan, Brian T. Burmeister, Graeme K. Carnegie, Li Wang, George S. Baillie
Publikováno v:
Cellular Signalling. 27:908-922
Hypertrophy increases the risk of heart failure and arrhythmia. Prevention or reversal of the maladaptive hypertrophic phenotype has thus been proposed to treat heart failure. Chronic β-adrenergic receptor (β-AR) stimulation induces cardiomyocyte h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ac2615ad0e03dbef9fe3ed21c783f5
https://doi.org/10.1016/j.cellsig.2015.02.003
https://doi.org/10.1016/j.cellsig.2015.02.003
Autor:
Kenneth R. Olson, Keven R. Johnson
Publikováno v:
Journal of Experimental Biology. 212:2991-2997
SUMMARY Natriuretic peptides (NPs) and their receptors (NPRs) comprise an evolutionarily conserved signaling system with profound physiological effects on vertebrate renal and cardiovascular systems. Some NPs (ANP, BNP and VNP)are primarily of cardia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f86f8739967492ed570cf2631ad5f4
https://doi.org/10.1242/jeb.031666
https://doi.org/10.1242/jeb.031666
Autor:
Keven R. Johnson, Kenneth R. Olson
Publikováno v:
General and Comparative Endocrinology. 157:21-26
The natriuretic peptide (NP) family is a seemingly ubiquitous sodium and volume reducing endocrine system of predominantly cardiac origin. Members of the NP system include ANP, BNP, CNP, VNP, their guanylate cyclase (GC)-linked receptors (NPR-A and N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb20608d121a461a740fca580269246b
https://doi.org/10.1016/j.ygcen.2008.03.026
https://doi.org/10.1016/j.ygcen.2008.03.026
Autor:
Graeme K. Carnegie, Michelle M. Monasky, Domenico M. Taglieri, Kathrin Banach, Jaime DeSantiago, Bruce R. Conklin, Keven R. Johnson, Matthew J. Spindler, Brian T. Burmeister
The objective of this study was to determine the role of A-Kinase Anchoring Protein (AKAP)-Lbc in the development of heart failure, by investigating AKAP-Lbc-protein kinase D1 (PKD1) signaling in vivo in cardiac hypertrophy. Using a gene-trap mouse e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d763d2bac0525275821d92b1123aaea6
https://escholarship.org/uc/item/18m8880g
https://escholarship.org/uc/item/18m8880g
Publikováno v:
BMC Evolutionary Biology, Vol 12, Iss 1, p 125 (2012)
BMC Evolutionary Biology
BMC Evolutionary Biology
Background A-Kinase Anchoring Proteins (AKAPs) are molecular scaffolding proteins mediating the assembly of multi-protein complexes containing cAMP-dependent protein kinase A (PKA), directing the kinase in discrete subcellular locations. Splice varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4606829a71322c2f0364c2481686d749
http://www.biomedcentral.com/1471-2148/12/125
http://www.biomedcentral.com/1471-2148/12/125
Autor:
Robert S. Danziger, Pieter P. deTombe, David L. Geenen, Jean Michel Grillon, Keven R. Johnson, Kumar Kotlo
Publikováno v:
Journal of proteomics. 77
There is over-whelming evidence that protein phosphorylations regulate cardiac function and remodeling. A wide variety of protein kinases, e.g., phosphoinositide 3-kinase (PI3K), Akt, GSK-3, TGFβ, and PKA, MAPKs, PKC, Erks, and Jaks, as well as phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456cf38cd065269fe6bc7f49f83dbc0c
https://pubmed.ncbi.nlm.nih.gov/22659219
https://pubmed.ncbi.nlm.nih.gov/22659219
Both histone-acetylations and histone deacetylases have been shown to play a key role in cardiac remodeling. Recently, it has become abundantly clear that many non-histone proteins are modified by post-translational lysine acetylations and that these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e91f5b71009bf17900d207847e94130
https://europepmc.org/articles/PMC3684243/
https://europepmc.org/articles/PMC3684243/
SUMMARY In mammals, natriuretic peptides (NPs) lower blood pressure, reduce blood volume and broadly inhibit cardiovascular remodeling. NPs are often referred to as cardiac hormones, though they also have integral roles in regulating vascular tone, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335fc928ff0bc4e689d46d9bbf6d2a55
https://europepmc.org/articles/PMC3144849/
https://europepmc.org/articles/PMC3144849/
Autor:
Kenneth R. Olson, Keven R. Johnson
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 296(4)
Natriuretic peptides (NPs) are evolutionarily conserved hormones that affect blood pressure and fluid volume through membrane-bound guanylate cyclase (GC)-linked natriuretic peptide receptors-A and -B (NPR-A and NPR-B, respectively) in a variety of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d1ad5c8e1482118d7bf748a7be7966
https://pubmed.ncbi.nlm.nih.gov/19176886
https://pubmed.ncbi.nlm.nih.gov/19176886