Time to onset of cannabidiol (CBD) treatment effect in Lennox–Gastaut syndrome: Analysis from two randomized controlled trials

Autor: J. Helen Cross, Matthew Wong, Daniel Checketts, Hari Bhathal, Elaine C. Wirrell, Maria Mazurkiewicz-Bełdzińska, Kevan E. VanLandingham, Michael Privitera, Eric D. Marsh, Volker Knappertz, Vicente Villanueva

Publikováno v: Epilepsia
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Objective To estimate time to onset of cannabidiol (CBD) treatment effect (seizure reduction and adverse events [AEs]), we conducted post hoc analyses of data from two randomized, placebo-controlled, Phase 3 trials, GWPCARE3 (NCT02224560) and GWPCARE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f4fab0d918904b91d2f52b9f26bcfa
https://doi.org/10.1111/epi.16878

Drug-drug Interaction Studies with Coadministration of Cannabidiol (CBD) and Clobazam, Valproate, Stiripentol or Midazolam in Healthy Volunteers and Adults with Epilepsy

Autor: Kevan E. VanLandingham, David Critchley, Jerzy P. Szaflarski, Philip Patsalos, Gilmour Morrison, Barry E. Gidal

Publikováno v: Neuropediatrics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6a4dfd3b586b47802b7db3a58c23e7
https://doi.org/10.1055/s-0039-1698213

Effect of cannabidiol on drop seizures in the Lennox–Gastaut syndrome

Autor: Orrin, Devinsky, Anup D, Patel, J Helen, Cross, Vicente, Villanueva, Elaine C, Wirrell, Michael, Privitera, Sam M, Greenwood, Claire, Roberts, Daniel, Checketts, Kevan E, VanLandingham, Sameer M, Zuberi, Liu Lin, Thio

Publikováno v: Chin, R 2018, ' Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome ', New England Journal of Medicine, vol. 378, no. 20, pp. 1888-1897 . https://doi.org/10.1056/NEJMoa1714631
Epilepsy Currents

Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome Devinsky O, Patel AD, Cross JH, et al; GWPCARE3 Study Group. N Engl J Med. 2018;378:1888-1897.Background:Cannabidiol has been used for treatment-resistant seizures in patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3696633d162bcac13c885eaf3d28c380
https://eprints.gla.ac.uk/163029/1/163029.pdf

Characteristics of valproic acid resistant juvenile myoclonic epilepsy

Autor: Aatif M. Husain, Kevan E. VanLandingham, Maria C. Fernando-Dongas, Rodney A. Radtke

Publikováno v: Seizure. 9(6):385-388

Juvenile myoclonic epilepsy (JME) is often exquisitely responsive to treatment with valproic acid (VPA). However, a subset of patients does not respond to this medication and often has intractable seizures. We wanted to identify differences between t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab3a0b37c1a56a217647013e5e60236

Migratory leptomeningeal inflammation with relapsing polychondritis

Autor: S. V. Kothare, Rodney A. Radtke, C.-C. Chu, Kevan E. VanLandingham, K. C. Richards, David A. Hosford

Publikováno v: Neurology. 51:614-617

We report a case of relapsing polychondritis with focal sensorimotor seizures, aseptic meningitis, and migratory leptomeningeal enhancement on contrast MRI. These abnormalities on imaging studies correlated accurately with laterality of the patient's

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5d548fd9f33e34237e2ebb01979ef4
https://doi.org/10.1212/wnl.51.2.614