Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

Autor: Tomer Cooks, Ioannis S. Pateras, Lisa M. Jenkins, Keval M. Patel, Ana I. Robles, James Morris, Tim Forshew, Ettore Appella, Vassilis G. Gorgoulis, Curtis C. Harris

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

p53 gain of function mutants (mutp53) are involved in the pathogenesis of most human cancers. Here, the authors show that mutp53 regulates the tumor microenvironment by inducing the release of specific exosomes containing miR-1246 that once received

Externí odkaz: https://doaj.org/article/c7c38fedb00642b095bd023227041cc0

Enhanced detection of circulating tumor DNA by fragment size analysis

Autor: Nitzan Rosenfeld, Christopher Smith, Charles E. Massie, Florent Mouliere, Ioannis Gounaris, Irena Hudecova, Lise Barlebo Ahlborn, Kevin M. Brindle, Christine Parkinson, Grant D. Stewart, Francesco Marass, Pippa Corrie, Richard D. Baird, Mercedes Jimenez-Linan, Dineika Chandrananda, James D. Brenton, Suzanne Murphy, Wendy N. Cooper, Johanna Burge, Matthew D. Eldridge, Anna Supernat, Olga Østrup, Morten Mau-Sørensen, Javier Garcia-Corbacho, Keval M. Patel, Elizabeth Moore, Davina Gale, James Morris, Simon Pacey, Michiel S. van der Heijden, Anna M. Piskorz, Katrin Heider, Jonathan C. M. Wan, Colin Watts, Richard Mair, Susana Ros, Teodora Goranova

Publikováno v: Science Translational Medicine, 10(466). American Association for the Advancement of Science
Mouliere, F, Chandrananda, D, Piskorz, A M, Moore, E K, Morris, J, Ahlborn, L B, Mair, R, Goranova, T, Marass, F, Heider, K, Wan, J C M, Supernat, A, Hudecova, I, Gounaris, I, Ros, S, Jimenez-Linan, M, Garcia-Corbacho, J, Patel, K, Østrup, O, Murphy, S, Eldridge, M D, Gale, D, Stewart, G D, Burge, J, Cooper, W N, van der Heijden, M S, Massie, C E, Watts, C, Corrie, P, Pacey, S, Brindle, K M, Baird, R D, Mau-Sørensen, M, Parkinson, C A, Smith, C G, Brenton, J D & Rosenfeld, N 2018, ' Enhanced detection of circulating tumor DNA by fragment size analysis ', Science Translational Medicine, vol. 10, no. 466 . https://doi.org/10.1126/scitranslmed.aat4921

Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alterations but have rarely considered the biological properties of plasma cell-free DNA (cfDNA). We hypothesized that differences in fragment lengths of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66fbdd69cec53a8010429a60ab38565

Association Of Plasma And Urinary Mutant DNA With Clinical Outcomes In Muscle Invasive Bladder Cancer

Autor: Keval M. Patel, Charles E. Massie, Vincent J. Gnanapragasam, Tim Forshew, K. E. van der Vos, Florent Mouliere, Francesco Marass, Dana W.Y. Tsui, Dineika Chandrananda, M.S. van der Heijden, D. Van Den Broek, James Morris, Nitzan Rosenfeld, David E. Neal, B.W.G. Van Rhijn, Christopher Smith

Publikováno v: Scientific Reports
Scientific Reports, 7(1):5554. Nature Publishing Group
Patel, K M, Van Der Vos, K E, Smith, C G, Mouliere, F, Tsui, D, Morris, J A, Chandrananda, D, Marass, F, Van Den Broek, D, Neal, D E, Gnanapragasam, V J, Forshew, T, Van Rhijn, B W, Massie, C E, Rosenfeld, N & Van Der Heijden, M S 2017, ' Association of Plasma and Urinary Mutant DNA with Clinical Outcomes in Muscle Invasive Bladder Cancer ', Scientific Reports, vol. 7, no. 1, 5554 . https://doi.org/10.1038/s41598-017-05623-3
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Muscle Invasive Bladder Cancer (MIBC) has a poor prognosis. Whilst patients can achieve a 6% improvement in overall survival with Neo-Adjuvant Chemotherapy (NAC), many do not respond. Body fluid mutant DNA (mutDNA) may allow non-invasive identificati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1b1f1faa8f073d5c875edc74a15d66
http://europepmc.org/articles/PMC5514073

Abstract 3701: Mutant p53 cancers reprogram tumor-associated macrophages via exosomal miR-1246

Autor: Tomer Cooks, Ettore Appella, James Morris, Ioannis S. Pateras, Keval M. Patel, Vassilis G. Gorgoulis, Lisa M. Miller Jenkins, Tim Forshew, Curtis C. Harris, Ana I. Robles

Publikováno v: Cancer Research. 77:3701-3701

TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers. Specific mutp53 proteins gain oncogenic functions (GOF) distinct from the tumor suppressor activity of the wild-type protein. Tumor-associated-macrophages, a hallmark of so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9daeb424bff5210517930bfa9a2abb6b
https://doi.org/10.1158/1538-7445.am2017-3701

Laparoscopic Colorectal Resection in Patients With Previous Abdominal and Colonic Surgery

Autor: Keval M. Patel, Najaf Siddiqi, Manfred Odermatt, Amjad Parvaiz, Qmar Zaman, Jim Khan

Publikováno v: Journal of Minimally Invasive Surgical Sciences. 4

Background: Previous abdominal surgery and its related adhesions are usually a relative contraindication for laparoscopic surgery or reason for conversion. Objectives: This study aim to identify patients with previous abdominal surgery and compare th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbebe48d748afe6409889faea7948c31
https://doi.org/10.17795/minsurgery-31968