Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Keunpoong, Lim"'
Autor:
Adam P. Mecca, Kelly Rogers, Zachary Jacobs, Julia W. McDonald, Hannah R. Michalak, Nicole DellaGioia, Wenzhen Zhao, Ansel T Hillmer, Nabeel Nabulsi, Keunpoong Lim, Jim Ropchan, Yiyun Huang, David Matuskey, Irina Esterlis, Richard E. Carson, Christopher H. van Dyck
Publikováno v:
NeuroImage, Vol 238, Iss , Pp 118217- (2021)
Objective: Metabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability. Methods: Cognitively nor
Externí odkaz:
https://doaj.org/article/e1f29b61815d49eb8468baa6a3682fc6
Autor:
Adam P. Mecca, Julia W. McDonald, Hannah R. Michalak, Tyler A. Godek, Joanna E. Harris, Erika A. Pugh, Emily C. Kemp, Ming-Kai Chen, Arash Salardini, Nabeel B. Nabulsi, Keunpoong Lim, Yiyun Huang, Richard E. Carson, Stephen M. Strittmatter, Christopher H. van Dyck
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Abstract Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We u
Externí odkaz:
https://doaj.org/article/fea1a7ff0aba43c19ea7e0af4b8ca35a
Autor:
Jason Bini, Jean-Dominique Gallezot, Songye Li, Keunpoong Lim, Paul Emery, Michael Kapinos, Jim Ropchan, Nabeel Nabulsi, Ania Jastreboff, Yiyun Huang, Richard Carson
Publikováno v:
Journal of the Endocrine Society. 6:A29-A30
Objectives Cortisol is known to promote adipocyte differentiation and maturation, and prolonged exposure to excess cortisol contributes to the development of obesity and metabolic dysregulation. The intracellular 11β-hydroxysteroid dehydrogenase typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15827235943d24ba6036b2fd1e92adc4
https://doi.org/10.1210/jendso/bvac150.062
https://doi.org/10.1210/jendso/bvac150.062
Autor:
Jon Mikael Anderson, Kelly P. Cosgrove, Stephanie S O' Malley, Jim Ropchan, Nabeel Nabulsi, John H. Krystal, Richard E. Carson, Ansel T. Hillmer, Gustavo A. Angarita, Keunpoong Lim, Irina Esterlis
Publikováno v:
Neuropsychopharmacology
Chronic alcohol use has important effects on the glutamate system. The metabotropic glutamate 5 (mGlu5) receptor has shown promise in preclinical models as a target to reduce drinking-related behaviors and cue-induced reinstatement, motivating human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c2e8d7163c69e0904bce543d1759e2
https://doi.org/10.1038/s41386-020-00856-9
https://doi.org/10.1038/s41386-020-00856-9
Autor:
Arash Salardini, Emily C Kemp, Yiyun Huang, Erika A Pugh, Nabeel Nabulsi, Adam P. Mecca, Keunpoong Lim, Ming-Kai Chen, Richard E. Carson, Joanna E. Harris, Christopher H. van Dyck, Stephen M. Strittmatter, Tyler A. Godek, Hannah R. Michalak, Julia W. McDonald
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We utilized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ac5b856268819588b67bd5ea1b92f
https://doaj.org/article/fea1a7ff0aba43c19ea7e0af4b8ca35a
https://doaj.org/article/fea1a7ff0aba43c19ea7e0af4b8ca35a
Autor:
Nicole DellaGioia, Nabeel Nabulsi, Adam P. Mecca, Julia W. McDonald, David Matuskey, Yiyun Huang, Ansel T. Hillmer, Jim Ropchan, Richard E. Carson, Wenzhen Zhao, Zachary Jacobs, Christopher H. van Dyck, Hannah R. Michalak, Irina Esterlis, Kelly Rogers, Keunpoong Lim
Publikováno v:
Neuroimage
NeuroImage, Vol 238, Iss, Pp 118217-(2021)
NeuroImage, Vol 238, Iss, Pp 118217-(2021)
Objective Metabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability. Methods Cognitively norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42d5a7377d641e8e079f6d41fa06f7f
https://europepmc.org/articles/PMC8378132/
https://europepmc.org/articles/PMC8378132/
Autor:
Wenjie Zhang, Zhengxin Cai, Lin Li, Jim Ropchan, Keunpoong Lim, Nabil E. Boutagy, Jing Wu, John C. Stendahl, Wenhua Chu, Robert Gropler, Albert J. Sinusas, Chi Liu, Yiyun Huang
Publikováno v:
Molecules, Vol 21, Iss 12, p 1696 (2016)
Reactive oxygen species (ROS) play important roles in cell signaling and homeostasis. However, an abnormally high level of ROS is toxic, and is implicated in a number of diseases. Positron emission tomography (PET) imaging of ROS can assist in the de
Externí odkaz:
https://doaj.org/article/1c0b6d4c950f4e38aae0050fecb88303
Autor:
Ryan S. O'Dell, Emily Laltoo, Christopher H. van Dyck, Sarah Savoia, Ansel T. Hillmer, Adam P. Mecca, Keunpoong Lim, Nabeel Nabulsi, Jim Ropchan, Richard E. Carson, Yiyun Huang, Joanna E. Harris, Tyler A. Godek, Stephen M. Strittmatter, Arsalan Hashemiaghdam, Kelly P. Cosgrove, Arash Salardini
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa9bf856b99168299efa995157915d89
https://doi.org/10.1002/alz.037792
https://doi.org/10.1002/alz.037792
Autor:
Christopher H. van Dyck, Ryan S. O'Dell, Jim Ropchan, Kelly P. Cosgrove, Joanna E. Harris, Emily Laltoo, Sarah Savoia, Arash Salardini, Keunpoong Lim, Adam P. Mecca, Stephen M. Strittmatter, Tyler A. Godek, Ansel T. Hillmer, Richard E. Carson, Arsalan Hashemiaghdam, Nabeel Nabulsi, Yiyun Huang
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15051283c83b6a4b443284b6d1dc395e
https://doi.org/10.1002/alz.043584
https://doi.org/10.1002/alz.043584
Autor:
Kevin N. Sheth, Haitian Zhao, Yiyun Huang, Jun Liu, Pan Zou, Ann T. Chen, Zeming Chen, Yang Xin, W. Taylor Kimberly, Jonathan Avery, Jiangbing Zhou, Daniel Holden, Fuyao Liu, Keunpoong Lim, Songye Li, Chao Ma, Richard E. Carson, Shenqi Zhang, Gang Deng, J. Marc Simard, Qianxue Chen, Fengyi Du
Publikováno v:
Theranostics
Stroke is a deadly disease without effective pharmacotherapies, which is due to two major reasons. First, most therapeutics cannot efficiently penetrate the brain. Second, single agent pharmacotherapy may be insufficient and effective treatment of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4eec3ad4a4ade5c8f1de031a4eb815
https://doi.org/10.7150/thno.35791
https://doi.org/10.7150/thno.35791