Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Keunhee Seo"'
Autor:
Heehwa G. Son, Mihwa Seo, Seokjin Ham, Wooseon Hwang, Dongyeop Lee, Seon Woo A. An, Murat Artan, Keunhee Seo, Rachel Kaletsky, Rachel N. Arey, Youngjae Ryu, Chang Man Ha, Yoon Ki Kim, Coleen T. Murphy, Tae-Young Roh, Hong Gil Nam, Seung-Jae V. Lee
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevit
Externí odkaz:
https://doaj.org/article/0c9bbbde0d4b4ce0a1014b73350edcc7
Autor:
Dongyeop Lee, Hyun-Jun Nam, Chanhee Kang, Jooyeon Sohn, Malene Hansen, Linnea M Adams, Yujin Lee, Eun Ji Kim, Seung-Yeol Park, Murat Artan, Dae-Eun Jeong, Dong Jin Moon, Wooseon Hwang, Seung-Jae Lee, Joo-Yeon Yoo, Mihwa Seo, Jeonghun Yeom, Yoonji Jung, Ozlem Altintas, Youngjae Ryu, Sang Ki Park, Cheolju Lee, Keunhee Seo, Sanguk Kim, Chang Man Ha, Seong Kyu Han, Nari Kim, Ara B. Hwang, Sungeun Ju
Publikováno v:
Science Advances
Description
MON-2, which mediates Golgi-endosome trafficking, mediates mitochondrial inhibition–induced longevity by enhancing autophagy.
The Golgi apparatus plays a central role in trafficking cargoes such as proteins and lipids. Defects
MON-2, which mediates Golgi-endosome trafficking, mediates mitochondrial inhibition–induced longevity by enhancing autophagy.
The Golgi apparatus plays a central role in trafficking cargoes such as proteins and lipids. Defects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f1fa669943e92aaf3320c27f96c02d
https://doi.org/10.1126/sciadv.abj8156
https://doi.org/10.1126/sciadv.abj8156
Autor:
Haeshim Baek, Eunseok Choi, Mihwa Seo, Chang Man Ha, Tae-Young Roh, Ao Lin Hsu, Sung Key Jang, Youngjae Ryu, Seon Woo A. An, Seokjin Ham, Seung-Jae Lee, Keunhee Seo, Yujin Lee, Heehwa G. Son, Eunju Kim, Sangsoon Park
Publikováno v:
Genes & Development. 32:1562-1575
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300f1a13bc5b3dded79e55dd1c3ae81a
https://doi.org/10.1101/gad.317362.118
https://doi.org/10.1101/gad.317362.118
Autor:
Eunah Kim, Joon Kim, Keunhee Seo, Sung Key Jang, Seung-Jae Lee, Junyoung Kwon, Seon Woo A. An, Ka Young Hong
Publikováno v:
Cellular and Molecular Life Sciences
The initiator tRNA (Met-tRNAiMet) at the P site of the small ribosomal subunit plays an important role in the recognition of an mRNA start codon. In bacteria, the initiator tRNA carrier, IF2, facilitates the positioning of Met-tRNAiMet on the small r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2de36ee59b2aba559ea68ba4a38033
http://europepmc.org/articles/PMC6208778
http://europepmc.org/articles/PMC6208778
Autor:
Hyunmin Kim, Youngsook Lee, Tae-Young Roh, Dongyeop Lee, Dae-Eun Jeong, Dae Won Moon, Yasuyo Yamaoka, Keunhee Seo, Heehwa G. Son, Abdul Aziz Khan, Seung-Jae Lee
Publikováno v:
Genes & Development. 29:2490-2503
Glucose-rich diets shorten the life spans of various organisms. However, the metabolic processes involved in this phenomenon remain unknown. Here, we show that sterol regulatory element-binding protein (SREBP) and mediator-15 (MDT-15) prevent the lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1dbed91b44f6714df46f4da6cf7bfa
https://doi.org/10.1101/gad.266304.115
https://doi.org/10.1101/gad.266304.115
Autor:
Sanguk Kim, Eunji Kim, Wooseon Hwang, Joo-Yeon Yoo, Jae-Seong Yang, Seung-Jae Lee, Bo Kyoung Suh, Hyun-Jun Nam, Heehwa G. Son, Seon Woo A. An, Eunseok Choi, Sang Ki Park, Ikue Mori, Youngjae Ryu, Keunhee Seo, Youngran Kim, Shunji Nakano, Nhung Thi-Cam Nguyen, Chang Man Ha
Publikováno v:
Aging Cell
PDZ domain‐containing proteins (PDZ proteins) act as scaffolds for protein–protein interactions and are crucial for a variety of signal transduction processes. However, the role of PDZ proteins in organismal lifespan and aging remains poorly unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33735d2dd9def0f0f1f09a51b96966eb
https://pubmed.ncbi.nlm.nih.gov/30773781
https://pubmed.ncbi.nlm.nih.gov/30773781
Autor:
Yujin Lee, Hyung-Jun Kim, Joo-Yeon Yoo, Heehwa G. Son, Mihwa Seo, Dongyeop Lee, Wooseon Hwang, Young Min Oh, Jay-Hyun Jo, Jee-Eun Lee, Sunyoung Hwang, Keunhee Seo, Ara B. Hwang, Seung-Jae Lee, Youngjae Ryu, Dae-Eun Jeong, Chang Man Ha, Murat Artan, Haeshim Baek
Mitochondria play key roles in cellular immunity. How mitochondria contribute to organismal immunity remains poorly understood. Here, we show that HSP‐60/HSPD1, a major mitochondrial chaperone, boosts anti‐bacterial immunity through the up‐regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36697e6deeea6faa3501bec21d463923
https://europepmc.org/articles/PMC5391144/
https://europepmc.org/articles/PMC5391144/
Autor:
Tae-Young Roh, Seokjin Ham, Murat Artan, Wooseon Hwang, Chang Man Ha, Yoon Ki Kim, Mihwa Seo, Rachel N. Arey, Seon Woo A. An, Rachel Kaletsky, Heehwa G. Son, Coleen T. Murphy, Seung-Jae Lee, Hong Gil Nam, Youngjae Ryu, Keunhee Seo, Dongyeop Lee
Publikováno v:
NATURE COMMUNICATIONS(8)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications
Long-lived organisms often feature more stringent protein and DNA quality control. However, whether RNA quality control mechanisms, such as nonsense-mediated mRNA decay (NMD), which degrades both abnormal as well as some normal transcripts, have a ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f3cd5677019384877158d356bb99f1
http://open-repository.kisti.re.kr/cube/handle/open_repository/484352.do
http://open-repository.kisti.re.kr/cube/handle/open_repository/484352.do
Publikováno v:
Aging Cell. 12:1073-1081
Summary Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecce72a9547f4687920939729cd1089
https://doi.org/10.1111/acel.12140
https://doi.org/10.1111/acel.12140
Autor:
Seong Kyu Han, Hee Jung Koo, Daehee Hwang, Keunhee Seo, Jae-Seong Yang, Hong Gil Nam, Wooseon Hwang, Sanguk Kim, Sung Key Jang, Seung-Jae Lee, Yoontae Lee, Mihwa Seo, Jeong-Hoon Hahm
Publikováno v:
Proceedings of the National Academy of Sciences. 112
The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d8b4e3f461cfa62472238a446c1127
https://doi.org/10.1073/pnas.1505451112
https://doi.org/10.1073/pnas.1505451112