Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Keun W. Park"'
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50874 (2012)
The present study investigates the involvement of the IL-6 family of cytokines, activation of the transcription factor Signal Transducer and Activator of Transcription-3 (STAT3), and the role of Suppressor Of Cytokine Signaling-3 (SOCS3) in regulatin
Externí odkaz:
https://doaj.org/article/ea16b5a2971844688d8942fe12f836cd
Publikováno v:
Experimental Neurology. 261:65-75
The present study investigates the endogenous expression of Suppressor of Cytokine Signaling-3 (SOCS3) after spinal cord injury (SCI) and its effect on SCI-induced cell death in vivo. In addition, we determined whether a reduction of SOCS3 expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9662fb903f9f032795b8b057df8950
https://doi.org/10.1016/j.expneurol.2014.06.013
https://doi.org/10.1016/j.expneurol.2014.06.013
Publikováno v:
Experimental neurology. 284
Suppressor of cytokine signaling-3 (SOCS3) expression is induced by the Janus kinase (JAK)-signal transducer and activator of transcription 3 (STAT3) signaling pathway. SOCS3 then acts as a feedback inhibitor of JAK-STAT signaling. Previous studies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daffc013740f619cec7fe3d2f2d0b71a
https://pubmed.ncbi.nlm.nih.gov/27502766
https://pubmed.ncbi.nlm.nih.gov/27502766
Autor:
Ju Young Park, Eun S. Park, Hyuk Wan Ko, Eun Sook Chung, Eugene Bok, Sung Hwa Yoon, Young Cheul Chung, So Y. Won, Byung Kwan Jin, Yoon Seong Kim, Keun W. Park, Sang Ryong Kim, Minyoung Jin
Publikováno v:
Neuropharmacology. 60:963-974
Parkinson's disease (PD) is characterized by degeneration of nigrostriatal dopaminergic (DA) neurons. Mice treated with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) exhibit microglial activation-induced oxidative stress and inflammation, and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00451eecd540ec3e8b951cd5de8cdf0c
https://doi.org/10.1016/j.neuropharm.2011.01.043
https://doi.org/10.1016/j.neuropharm.2011.01.043
Autor:
Byung K. Jin, Keun W. Park
Publikováno v:
Journal of Neuroscience Research. 86:1053-1063
The present study investigated whether thrombin can induce the production of reactive oxygen species (ROS) through activation of neuronal NADPH oxidase and whether this contributes to oxidative damage and consequently to neurodegeneration. Immunocyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58eb047f69456be4146da026427dcae
https://doi.org/10.1002/jnr.21571
https://doi.org/10.1002/jnr.21571
Autor:
Byung K. Jin, Young Cheul Chung, Eun Sook Chung, Eun S. Park, Eugene Bok, Sang Ryong Kim, So Y. Won, Keun W. Park
Publikováno v:
Molecular Neurobiology. 35:245-254
Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c489e03efe7ab24e496f24ed981c9a8
https://doi.org/10.1007/s12035-007-0030-1
https://doi.org/10.1007/s12035-007-0030-1
Autor:
Da-Yong Lee, Eun-Hye Joe, Keun W. Park, Byung K. Jin, Myung-Soon Yang, Won Ho Shin, Seung U. Kim
Publikováno v:
Glia. 46:142-152
How to minimize brain inflammation is pathophysiologically important, since inflammation induced by microglial activation can exacerbate brain damage. In the present report, we show that injection of lipopolysaccharide (LPS) into the rat cortex led t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663ab79cc231a6639d949f666d506dc9
https://doi.org/10.1002/glia.10357
https://doi.org/10.1002/glia.10357
Autor:
Laurie E. Harrington, Andrew T. Holdbrooks, Yudong Liu, Chander Raman, Keun W. Park, Michelle T. Muldowney, Patrizia De Sarno, Wen-I Yeh, Thomas H. Fox, Hongwei Qin, Stephanie L. Reynolds, Lora L. Yanagisawa, Etty N. Benveniste
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(13)
Suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of the JAK/STAT pathway. SOCS3 has a crucial role in inhibiting STAT3 activation, cytokine signaling, and inflammatory gene expression in macrophages/microglia. To determine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd9e525eb45019f15bdcc6ee42bde66
https://pubmed.ncbi.nlm.nih.gov/22411837
https://pubmed.ncbi.nlm.nih.gov/22411837
Autor:
J.H. Nam, E.S. Park, B.K. Jin, Y.B. Lee, J. Park, Hyung Hwan Baik, H.G. Lee, Y.-S. Kim, Keun W. Park, S. Maeng
Publikováno v:
Antioxidantsredox signaling. 16(12)
The present study examined whether Aβ(1-42) can induce endogenous expression of interleukin-13 (IL-13) or (IL-4) within activated microglia in the rat hippocampus in vivo. We further investigated whether these cytokines mediate ROS/RNS generation th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e4cdbe9d7c6868d8be89c108059f56
https://pubmed.ncbi.nlm.nih.gov/22248368
https://pubmed.ncbi.nlm.nih.gov/22248368
Publikováno v:
Glia. 58(9)
Elevated levels of Oncostatin M (OSM), an interleukin-6 family cytokine, have been observed in multiple sclerosis (MS), HIV-associated neurocognitive disorder (HAND), and glioblastoma (GBM); however, its effects within the CNS are not well understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09183068d79728ec3c7efa7316a721f1
https://pubmed.ncbi.nlm.nih.gov/20468050
https://pubmed.ncbi.nlm.nih.gov/20468050