Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Keun Il Kim"'
Autor:
Jaebeom Kim, Young Suk Yu, Yehwa Choi, Do Hui Lee, Soobin Han, Junhee Kwon, Taichi Noda, Masahito Ikawa, Dongha Kim, Hyunkyung Kim, Andrea Ballabio, Keun Il Kim, Sung Hee Baek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Autophagy, a highly conserved self-digestion process crucial for cellular homeostasis, is triggered by various environmental signals, including nutrient scarcity. The regulation of lysosomal and autophagy-related processes is pivotal to main
Externí odkaz:
https://doaj.org/article/a75de0b1c5ca46939258d4aa4ae70597
Autor:
Namjoon Cho, Yong-Eun Kim, Yunkyeong Lee, Dong Wook Choi, Chungoo Park, Jung-Hwan Kim, Keun Il Kim, Kee K. Kim
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 261-271 (2024)
ABSTRACTThe ring finger protein 113A (RNF113A) serves as an E3 ubiquitin ligase and a subunit of the spliceosome. Mutations in the RNF113A gene are associated with X-linked trichothiodystrophy (TTD). However, the cellular roles of RNF113A remain larg
Externí odkaz:
https://doaj.org/article/0536be66c84a4b299ace99c6d764f7a5
Publikováno v:
Animal Cells and Systems, Vol 27, Iss 1, Pp 29-37 (2023)
ABSTRACTCells activate protective mechanisms to overcome stressful conditions that threaten cellular homeostasis, including imbalances in calcium, redox, and nutrient levels. Endoplasmic reticulum (ER) stress activates an intracellular signaling path
Externí odkaz:
https://doaj.org/article/00ea4828892546589abf6feabfe5f3e6
Publikováno v:
Animal Cells and Systems, Vol 0, Iss 0, Pp 1-9 (2022)
Autophagy modulators are considered putative therapeutic targets because of the role of autophagy in cancer progression. Kazinol C, a 1,3-diphenylpropane from the plant Broussonetia kazinoki, has been shown to induce apoptosis in colon cancer cells t
Externí odkaz:
https://doaj.org/article/9479d1d5b53e4e929865254cf0ac7807
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-14 (2021)
Abstract Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a p
Externí odkaz:
https://doaj.org/article/ce904ee523184e61982e6a34f3e5c449
Autor:
Kyeongkyu Kim, Kyungjin Boo, Young Suk Yu, Se Kyu Oh, Hyunkyung Kim, Yoon Jeon, Jinhyuk Bhin, Daehee Hwang, Keun Il Kim, Jun-Su Lee, Seung-Soon Im, Seul Gi Yoon, Il Yong Kim, Je Kyung Seong, Ho Lee, Sungsoon Fang, Sung Hee Baek
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Hepatic steatosis development may result from dysregulation of lipid metabolism, which is finely tuned by several transcription factors including the PPAR family. Here Kim et al. show that the nuclear receptor RORα inhibits PPARγ-mediated transcrip
Externí odkaz:
https://doaj.org/article/36d6b97040c64edea81c79e689652260
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2878-2890.e4 (2018)
Summary: Unc-51-like-kinase 1 (ULK1) is a target of both the mechanistic target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), whose role is to facilitate the initiation of autophagy in response to starvation. Upon glucose starvation, d
Externí odkaz:
https://doaj.org/article/a8c268a9684444c89fb35e8a56079024
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 639 (2020)
Lung diseases, such as pulmonary hypertension and pulmonary fibrosis, are life-threatening diseases and have common features of vascular remodeling. During progression, extracellular matrix protein deposition and dysregulation of proteolytic enzymes
Externí odkaz:
https://doaj.org/article/6d1206b7c6394fe9852a7383b121d1d7
Autor:
Ye Ji Kim, Eui Tae Kim, Young-Eui Kim, Myoung Kyu Lee, Ki Mun Kwon, Keun Il Kim, Thomas Stamminger, Jin-Hyun Ahn
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005850 (2016)
Interferon-stimulated gene 15 (ISG15) encodes an ubiquitin-like protein that covalently conjugates protein. Protein modification by ISG15 (ISGylation) is known to inhibit the replication of many viruses. However, studies on the viral targets and vira
Externí odkaz:
https://doaj.org/article/71c0100d7306480086f55f80d6cddf7e
Autor:
Shifeng Hong, Shuo Jin, Yue Deng, Regina Garcia-Mendez, Keun-il Kim, Nyalaliska Utomo, Lynden A. Archer
Publikováno v:
ACS Energy Letters. 8:1744-1751