New realm of precision multiplexing enabled by massively-parallel single molecule UltraPCR.

Autor: Lai JH, Keum JW, Lee HG, Molaei M, Blair EJ, Li S, Soliman JW, Raol VK, Barker CL, Fodor SPA, Fan HC, Shum EY

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 11. Date of Electronic Publication: 2023 Oct 11.

Full sequence of mutant huntingtin 3'-untranslated region and modulation of its gene regulatory activity by endogenous microRNA.

Autor: Kim KH; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA., Abu Elneel K; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Shin JW; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA., Keum JW; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Seong D; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Kwak S; CHDI Foundation, Princeton, NJ, 08540, USA., Lee R; CHDI Foundation, Princeton, NJ, 08540, USA., Gusella JF; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.; Medical and Population Genetics Program, The Broad Institute of M.I.T. and Harvard, Cambridge, MA, 02142, USA., MacDonald ME; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA.; Medical and Population Genetics Program, The Broad Institute of M.I.T. and Harvard, Cambridge, MA, 02142, USA., Seong IS; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA., Lee JM; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA. jlee51@mgh.harvard.edu.; Department of Neurology, Harvard Medical School, Boston, MA, 02115, USA. jlee51@mgh.harvard.edu.; Medical and Population Genetics Program, The Broad Institute of M.I.T. and Harvard, Cambridge, MA, 02142, USA. jlee51@mgh.harvard.edu.

Publikováno v: Journal of human genetics [J Hum Genet] 2019 Oct; Vol. 64 (10), pp. 995-1004. Date of Electronic Publication: 2019 Jul 11.

The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease.

Autor: Keum JW; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA., Shin A; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA., Gillis T; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA., Mysore JS; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA., Abu Elneel K; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA., Lucente D; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA., Hadzi T; GNS Healthcare Inc., One Charles Park, Cambridge, MA 02142, USA., Holmans P; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff CF24 4HQ, UK; Genetic Modifiers of Huntington's Disease Consortium., Jones L; Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff CF24 4HQ, UK; Genetic Modifiers of Huntington's Disease Consortium., Orth M; Department of Neurology, University of Ulm, Ulm 089081, Germany; Genetic Modifiers of Huntington's Disease Consortium., Kwak S; CHDI Foundation, Princeton, NJ 08540, USA; Genetic Modifiers of Huntington's Disease Consortium., MacDonald ME; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Genetic Modifiers of Huntington's Disease Consortium., Gusella JF; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Genetic Modifiers of Huntington's Disease Consortium., Lee JM; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Genetic Modifiers of Huntington's Disease Consortium. Electronic address: jlee51@mgh.harvard.edu.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2016 Feb 04; Vol. 98 (2), pp. 287-98.

The role of defects on the assembly and stability of DNA nanostructures.

Autor: Greene DG; Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA., Keum JW, Bermudez H

Publikováno v: Small (Weinheim an der Bergstrasse, Germany) [Small] 2012 May 07; Vol. 8 (9), pp. 1320-5. Date of Electronic Publication: 2012 Feb 22.

Controlling forces and pathways in self-assembly using viruses and DNA.

Autor: Keum JW; Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, USA., Hathorne AP, Bermudez H

Publikováno v: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology [Wiley Interdiscip Rev Nanomed Nanobiotechnol] 2011 May-Jun; Vol. 3 (3), pp. 282-97. Date of Electronic Publication: 2011 Mar 07.