Zobrazeno 1 - 10 of 44 pro vyhledávání: '"Ketul R, Chaudhary"'
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Akademický článek
Penetrance of Severe Pulmonary Arterial Hypertension in Response to Vascular Endothelial Growth Factor Receptor 2 Blockade in a Genetically Prone Rat Model Is Reduced by Female Sex
Autor: Ketul R. Chaudhary, Yupu Deng, Anli Yang, Nicholas D. Cober, Duncan J. Stewart
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 15 (2021)
Background We have previously reported important strain differences in response to SU5416 (SU, a vascular endothelial growth factor receptor 2 inhibitor) in rats and have identified a specific colony of Sprague‐Dawley rats that are hyperresponsive
Externí odkaz: https://doaj.org/article/bd6bdc2e89554db99b9fe9ce8e38bd00
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3
Akademický článek
Optimizing imaging of the rat pulmonary microvasculature by micro-computed tomography
Autor: Yupu Deng, Katelynn J. Rowe, Ketul R. Chaudhary, Anli Yang, Shirley H.J. Mei, Duncan J. Stewart
Publikováno v: Pulmonary Circulation, Vol 9 (2019)
Micro-computed tomography (micro-CT) is used in pre-clinical research to generate high-resolution three-dimensional (3D) images of organs and tissues. When combined with intravascular contrast agents, micro-CT can provide 3D visualization and quantif
Externí odkaz: https://doaj.org/article/bea2708717bb4f3eb550cf6fbedeb5ea
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4
Single-cell microencapsulation improves lung retention of endothelial colony forming cells after intravascular delivery and unmasks therapeutic benefit in severe pulmonary arterial hypertension
Autor: Nicholas D. Cober, Ketul R. Chaudhary, Yupu Deng, Chyan-Jang Lee, Katelynn Rowe, David W. Courtman, Duncan J. Stewart
BackgroundPulmonary arterial hypertension (PAH) is triggered by pulmonary vascular endothelial cell apoptosis and microvascular loss; therefore, therapies that can regenerate lost vasculature may offer therapeutic benefit. Endothelial colony forming
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52b5765226a18ca65be76f5cad83f36a
https://doi.org/10.1101/2022.11.05.514522
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6
Abstract 12319: 16alpha-Hydroxyestrone Downregulates SOX17 During the Development of Pulmonary Arterial Hypertension
Autor: Shreya Sangam, Tae-Hwi Schwantes-An, John Zagorski, Yinan Shi, Seth Morrisroe, Todd Cook, Amanda Fisher, Andrea Frump, Anna Coleman, Haiyang Tang, Howard Crawford, Katie Lutz, Michael W Pauciulo, Ketul R Chaudhary, Duncan J Stewart, Tim Lahm, William C Nichols, Ankit A Desai
Publikováno v: Circulation. 144
Introduction: Sexual dimorphism in pulmonary arterial hypertension (PAH) is attributed, in part, to estrogen signaling. 16α-hydroxyestrone (16αOHE) is considered a major contributor to PAH pathogenesis. Recent genetic studies have also suggested th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c43032bb90a6456f2147454ccfd1f7d2
https://doi.org/10.1161/circ.144.suppl_1.12319
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7
Penetrance of Severe Pulmonary Arterial Hypertension in Response to Vascular Endothelial Growth Factor Receptor 2 Blockade in a Genetically Prone Rat Model Is Reduced by Female Sex
Autor: Anli Yang, Duncan J. Stewart, Yupu Deng, Nicholas D Cober, Ketul R Chaudhary
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We have previously reported important strain differences in response to SU5416 (SU, a vascular endothelial growth factor receptor 2 inhibitor) in rats and have identified a specific colony of Sprague‐Dawley rats that are hyperresponsive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d945eaff0bf894871976a7c8b9ae4f
https://doi.org/10.1161/jaha.120.019488
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8
Medical Therapy for Heart Failure Associated With Pulmonary Hypertension
Autor: Lisa Mielniczuk, Jason G.E. Zelt, Duncan J. Stewart, Ketul R Chaudhary, Virgilio J. J. Cadete
Publikováno v: Circulation Research. 124:1551-1567
The past 2 decades have witnessed a >40% improvement in mortality for patients with heart failure and left ventricular systolic dysfunction. 1 This success has coincided with the stepwise availability of drugs that target neurohormonal activation: β
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5e4902e129ca068ccd3680102f0b9b
https://doi.org/10.1161/circresaha.118.313650
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9
The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still 'the One:' A Model of Group 1 Pulmonary Hypertension: Reply to Le Cras and Abman
Autor: Harm Jan Bogaard, Xiao-Qing Sun, Ketul R Chaudhary, Maximilian Ackermann, Duncan J. Stewart, Mark P. Kühnel, Danny Jonigk, Georg Hansmann, Ekaterina Legchenko
Publikováno v: American Journal of Respiratory and Critical Care Medicine, 201(5), 621-624. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine
Bogaard, H J, Legchenko, E, Ackermann, M, Kühnel, M P, Jonigk, D D, Chaudhary, K R, Sun, X, Stewart, D J & Hansmann, G 2020, ' The Adult Sprague-Dawley Sugen-Hypoxia Rat Is Still "the One:" A Model of Group 1 Pulmonary Hypertension : Reply to Le Cras and Abman ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 5, pp. 621-624 . https://doi.org/10.1164/rccm.201910-1983LE
To the editor: Kojonazarov et al. recently reported severe emphysema in the SU5416/Hypoxia (SuHx) rat model of pulmonary hypertension (1). The authors found that adult male Wistar Kyoto (WKY) rats had increased air-to-tissue ratio as judged by non-ga
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460119ed3dc047fe9f1e672df9bb3aee
https://research.vumc.nl/en/publications/18e44574-5e3a-489b-8f09-d145f898bb60
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10
Fischer rats exhibit maladaptive structural and molecular right ventricular remodelling in severe pulmonary hypertension: a genetically prone model for right heart failure
Autor: Ketul R Chaudhary, Colin Suen, Duncan J. Stewart, Yupu Deng, Baohua Jiang
Publikováno v: Cardiovascular Research. 115:788-799
Aims The ability of the right ventricle (RV) to adapt to increased afterload is the major determinant of survival in patients with pulmonary hypertension (PH). In this study, we explored the effect of genetic background on RV adaptation and survival
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be15552c36ac9133301942a73e2376c2
https://doi.org/10.1093/cvr/cvy258
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