Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ketty Hakim-Mishnaevski"'
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Glial phagocytosis of apoptotic neurons is crucial for development and proper function of the central nervous system. Relying on transmembrane receptors located on their protrusions, phagocytic glia recognize and engulf apoptotic debris. Lik
Externí odkaz:
https://doaj.org/article/a6d14ebb493146dbb5bfa140324f549a
Autor:
Lital Dabool, Ketty Hakim-Mishnaevski, Liza Juravlev, Naama Flint-Brodsly, Silvia Mandel, Estee Kurant
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101375- (2020)
Summary: Skp1, a component of the ubiquitin E3 ligases, was found to be decreased in the brains of sporadic Parkinson's disease (PD) patients, and its overexpression prevented death of murine neurons in culture. Here we expose the neuroprotective rol
Externí odkaz:
https://doaj.org/article/caa5fe7284d84cc2af3601b1bebf6e3c
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1438-1448.e3 (2019)
Summary: Glial phagocytosis is critical for the development and maintenance of the CNS in vertebrates and flies and relies on the function of phagocytic receptors to remove apoptotic cells and debris. Glial phagocytic ability declines with age, which
Externí odkaz:
https://doaj.org/article/929ef5fb9f0f4c1e8d3e1904f5173230
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
During Drosophila embryogenesis, a large number of apoptotic cells are efficiently engulfed and degraded by professional phagocytes, macrophages. Phagocytic receptors Six-Microns-Under (SIMU), Draper (Drpr) and Croquemort (Crq) are specifically expre
Externí odkaz:
https://doaj.org/article/b28d3123312740dc9d55000929095f5e
Autor:
Maayan Zohar-Fux, Aya Ben-Hamo-Arad, Tal Arad, Marina Volin, Boris Shklyar, Ketty Hakim-Mishnaevski, Lilach Porat-Kuperstein, Estee Kurant, Hila Toledano
Publikováno v:
Science Advances. 8
Phagoptosis is a frequently occurring nonautonomous cell death pathway in which phagocytes eliminate viable cells. While it is thought that phosphatidylserine (PS) “eat-me” signals on target cells initiate the process, the precise sequence of eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea9009ea79abf10428bc6e710d9f9b35
https://doi.org/10.1126/sciadv.abm4937
https://doi.org/10.1126/sciadv.abm4937
A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila
Autor:
Bianca Petrignani, Mickael Poidevin, Florent Masson, Shu Kondo, Bruno Lemaitre, Reut Hilu‐Dadia, Ketty Hakim-Mishnaevski, Estee Kurant, Elodie Ramond, Samuel Rommelaere
Publikováno v:
EMBO Reports
Programmed cell death plays a fundamental role in development and tissue homeostasis. Professional and non‐professional phagocytes achieve the proper recognition, uptake, and degradation of apoptotic cells, a process called efferocytosis. Failure i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2c0c7f55727eace83613047c0e05e1
https://doi.org/10.15252/embr.202052262
https://doi.org/10.15252/embr.202052262
Publikováno v:
Glia. 66:1520-1532
Development of the central nervous system involves elimination of superfluous neurons through apoptosis and subsequent phagocytosis. In Drosophila, this occurs mainly during three developmental stages: embryogenesis, metamorphosis and emerging adult.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdcaade833a01c7cd164fe53642615a
https://doi.org/10.1002/glia.23322
https://doi.org/10.1002/glia.23322
Autor:
Ketty Hakim-Mishnaevski, Naama Flint-Brodsly, Estee Kurant, Liza Juravlev, Silvia Mandel, Lital Dabool
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101375-(2020)
iScience
iScience
Summary Skp1, a component of the ubiquitin E3 ligases, was found to be decreased in the brains of sporadic Parkinson's disease (PD) patients, and its overexpression prevented death of murine neurons in culture. Here we expose the neuroprotective role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d527f449071dafca5b2d7c4bfa29a0
https://doi.org/10.1016/j.isci.2020.101375
https://doi.org/10.1016/j.isci.2020.101375
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1438-1448.e3 (2019)
Summary: Glial phagocytosis is critical for the development and maintenance of the CNS in vertebrates and flies and relies on the function of phagocytic receptors to remove apoptotic cells and debris. Glial phagocytic ability declines with age, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e080ca58634f386719c834b833c2c751
https://pubmed.ncbi.nlm.nih.gov/31693886
https://pubmed.ncbi.nlm.nih.gov/31693886
Publikováno v:
Journal of neuroscience methods. 311
Background Protein aggregation in neurons is a prominent pathological mark of neurodegeneration. In Parkinson’s disease (PD), inclusions of the α-Synuclein (α-Syn) protein form the Lewy bodies in dopaminergic (DA) neurons. Ectopic expression of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21b8d4c479e7826bd6e59bac7c86e65
https://pubmed.ncbi.nlm.nih.gov/30336223
https://pubmed.ncbi.nlm.nih.gov/30336223